P52448 (AN_HHV6Z) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alkaline nuclease
EC=3.1.-.-

Gene names

Name:	U70
Synonyms:	CH3R

Organism

Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) [Reference proteome]

Taxonomic identifier

36351 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Betaherpesvirinae › Roseolovirus › Human herpesvirus 6B (strain HST)

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	488 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the baculo-herpesviridae alkaline nuclease family.

Ontologies

Keywords
Molecular function	Endonuclease Exonuclease Hydrolase Nuclease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	nucleic acid phosphodiester bond hydrolysis Inferred from electronic annotation. Source: GOC
Molecular_function	DNA binding Inferred from electronic annotation. Source: InterPro endonuclease activity Inferred from electronic annotation. Source: UniProtKB-KW exonuclease activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 488	488	Alkaline nuclease		PRO_0000115695

Sequences

	Sequence		Length	Mass (Da)
	P52448 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: AE2872028D4B3D90	FASTA	488	56,688
	10 20 30 40 50 60 MDLNQISETL SAVAEEEPLT MFLLDKLYAI REKIKQVPFS IVRLCHVYCM LIKYNASNNN 70 80 90 100 110 120 CILGRKLIEE MQQFLCGARV DGSEDVSMDM SELCKLYDYC PLLCSALCRA PCVFVNKLFK 130 140 150 160 170 180 IVERETRGQS ENPLWHALRR YTVTATKLYD IYTTRNFLEH KGQQFFGEAV IYGAKHERVI 190 200 210 220 230 240 RHLVAIFYVK REVKETLGLL LDPSSGVFGA SLDACFGISF NEDGFLMVKE KALIFEIKFR 250 260 270 280 290 300 YKYLRDKEDH FVSELLKNPT EKSFSDFILS HPVPAIEFRE RGKIPSSREY LMTYDFQYRP 310 320 330 340 350 360 QRKLRTCPTP AILTPHIKQL LCLNETQTST VIVFDCKSHL SEQKLSVFQK AVFTVNVFVN 370 380 390 400 410 420 PKHRYFFQSL LQQYVMTQFY INDHSNPEYI ESTEVPSVHI VTALFRRRTE EERSLHLVID 430 440 450 460 470 480 ETEYIEEEIP LALIVTPVAP NPEFTCRVIT DICNLWENNI CKQTSLQVWA QSAVNQYLAA CVRKPKTP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Restriction endonuclease mapping and molecular cloning of the human herpesvirus 6 variant B strain Z29 genome." Lindquester G.J., Inoue N., Allen R.D., Castelli J.W., Stamey F.R., Dambaugh T.R., O'Brian J.J., Danovich R.M., Frenkel N., Pellett P.E. Arch. Virol. 141:367-379(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Human herpesvirus 6B genome sequence: coding content and comparison with human herpesvirus 6A." Dominguez G., Dambaugh T.R., Stamey F.R., Dewhurst S., Inoue N., Pellett P.E. J. Virol. 73:8040-8052(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF157706 Genomic DNA. Translation: AAB06353.1.
PIR	T44215.
RefSeq	NP_050249.1. NC_000898.1.
3D structure databases
ProteinModelPortal	P52448.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1497070.
Phylogenomic databases
ProtClustDB	CLSP2510089.
Family and domain databases
Gene3D	3.90.320.10. 1 hit.
InterPro	IPR011604. Exonuc_phg/RecB_C. IPR001616. Herpes_alk_exo. IPR011335. Restrct_endonuc-II-like. [Graphical view]
Pfam	PF01771. Herpes_alk_exo. 1 hit. [Graphical view]
PRINTS	PR00924. ALKEXNUCLASE.
SUPFAM	SSF52980. Restrict_endonuc_II-like_core. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AN_HHV6Z

Accession

Primary (citable) accession number: P52448

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	April 3, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program