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Protein

DNA-directed RNA polymerases I and III subunit RPAC1

Gene

Polr1c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription

Enzyme and pathway databases

ReactomeiR-MMU-5250924 B-WICH complex positively regulates rRNA expression
R-MMU-73762 RNA Polymerase I Transcription Initiation
R-MMU-73772 RNA Polymerase I Promoter Escape
R-MMU-73777 RNA Polymerase I Chain Elongation
R-MMU-73863 RNA Polymerase I Transcription Termination
R-MMU-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-MMU-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter
R-MMU-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerases I and III subunit RPAC1
Short name:
DNA-directed RNA polymerase I subunit C
Short name:
RNA polymerases I and III subunit AC1
Alternative name(s):
AC40
DNA-directed RNA polymerases I and III 40 kDa polypeptide
Short name:
RPA40
RPC40
Gene namesi
Name:Polr1c
Synonyms:Rpo1-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:103288 Polr1c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi73A → D: Unable to interact with RPB14. 1 Publication1
Mutagenesisi73A → R: Temperature-sensitive defect in the interaction with RPB14. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001327402 – 346DNA-directed RNA polymerases I and III subunit RPAC1Add BLAST345

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP52432
MaxQBiP52432
PaxDbiP52432
PeptideAtlasiP52432
PRIDEiP52432

PTM databases

iPTMnetiP52432
PhosphoSitePlusiP52432

Expressioni

Gene expression databases

BgeeiENSMUSG00000067148
CleanExiMM_POLR1E
ExpressionAtlasiP52432 baseline and differential
GenevisibleiP52432 MM

Interactioni

Subunit structurei

Component of the RNA polymerase I (Pol I) and RNA polymerase III (Pol III) complexes consisting of at least 13 and 17 subunits, respectively.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202992, 1 interactor
IntActiP52432, 1 interactor
MINTiP52432
STRINGi10090.ENSMUSP00000084252

Structurei

3D structure databases

ProteinModelPortaliP52432
SMRiP52432
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1521 Eukaryota
COG0202 LUCA
GeneTreeiENSGT00550000075060
HOVERGENiHBG017743
InParanoidiP52432
KOiK03027
OMAiRGKDHAK
OrthoDBiEOG091G03FZ
TreeFamiTF103034

Family and domain databases

CDDicd07032 RNAP_I_II_AC40, 1 hit
Gene3Di2.170.120.12, 1 hit
InterProiView protein in InterPro
IPR001514 DNA-dir_RNA_pol_30-40kDasu_CS
IPR011262 DNA-dir_RNA_pol_insert
IPR011263 DNA-dir_RNA_pol_RpoA/D/Rpb3
IPR036603 RBP11-like
IPR033901 RNAPI/II_AC40
IPR036643 RNApol_insert_sf
PANTHERiPTHR11800:SF13 PTHR11800:SF13, 1 hit
PfamiView protein in Pfam
PF01000 RNA_pol_A_bac, 1 hit
PF01193 RNA_pol_L, 1 hit
SMARTiView protein in SMART
SM00662 RPOLD, 1 hit
SUPFAMiSSF55257 SSF55257, 2 hits
SSF56553 SSF56553, 1 hit
PROSITEiView protein in PROSITE
PS00446 RNA_POL_D_30KD, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52432-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAQAVEEM RTRVVLGEFG VRNVHTTDFP GNYAGYDDAW DQNRFEKNFR
60 70 80 90 100
VDVVQMDEDT LEFDMVGIDA AIANAFRRIL LAEVPTMAVE KVLVYNNTSI
110 120 130 140 150
VQDEILAHRL GLIPILADPR LFEYRNQGEE EGTEIDTLQF RLQVRCTRNP
160 170 180 190 200
NAAKDSSDPN ELYVNHKVYT RHMTWVPLGN QADVFPEGTI RPVHDDILIA
210 220 230 240 250
QLRPGQEIDL MMHCVKGIGK DHAKFSPVAT ASYRLLPAIT LLEPVEGEAA
260 270 280 290 300
EELSQCFSPG VIEVEEVQGK KVARVANARL DTFSREIFRH EKLKKAVRLA
310 320 330 340
RVRDHYIFSV ESTGVLPPDV LVSEAIKILM GKCRRFLDEL DAVEMD
Length:346
Mass (Da):39,107
Last modified:July 27, 2011 - v3
Checksum:iC2115C1526974344
GO

Sequence cautioni

The sequence BAA06735 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52D → G in BAA06735 (PubMed:7929437).Curated1
Sequence conflicti83E → R in BAA06735 (PubMed:7929437).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31966 mRNA Translation: BAA06735.1 Different initiation.
AK132114 mRNA Translation: BAE20986.1
AK146240 mRNA Translation: BAE27005.1
CH466559 Genomic DNA Translation: EDL23483.1
CCDSiCCDS37632.1
PIRiA55082
RefSeqiNP_033111.2, NM_009085.2
UniGeneiMm.3458

Genome annotation databases

EnsembliENSMUST00000087026; ENSMUSP00000084252; ENSMUSG00000067148
GeneIDi20016
KEGGimmu:20016
UCSCiuc008csc.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRPAC1_MOUSE
AccessioniPrimary (citable) accession number: P52432
Secondary accession number(s): Q3UJZ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 150 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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