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Protein

Proteasome subunit alpha type-1

Gene

PAF1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiR-OSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-OSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-OSA-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-OSA-5632684 Hedgehog 'on' state
R-OSA-5687128 MAPK6/MAPK4 signaling
R-OSA-5689603 UCH proteinases
R-OSA-5689880 Ub-specific processing proteases
R-OSA-69017 CDK-mediated phosphorylation and removal of Cdc6
R-OSA-69229 Ubiquitin-dependent degradation of Cyclin D1
R-OSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alpha type-1 (EC:3.4.25.1)
Alternative name(s):
20S proteasome alpha subunit F
20S proteasome subunit alpha-6
Proteasome component C2
Gene namesi
Name:PAF1
Ordered Locus Names:Os02g0133800, LOC_Os02g04100
ORF Names:OsJ_05275Imported, P0030G11.18, P0585B01.3
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001240741 – 270Proteasome subunit alpha type-1Add BLAST270

Proteomic databases

PaxDbiP52428
PRIDEiP52428

Expressioni

Gene expression databases

ExpressionAtlasiP52428 differential
GenevisibleiP52428 OS

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Protein-protein interaction databases

STRINGi39947.LOC_Os02g04100.1

Structurei

3D structure databases

ProteinModelPortaliP52428
SMRiP52428
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0863 Eukaryota
COG0638 LUCA
HOGENOMiHOG000091080
InParanoidiP52428
KOiK02725
OMAiFMKQQCL
OrthoDBiEOG09360K5D

Family and domain databases

CDDicd03749 proteasome_alpha_type_1, 1 hit
Gene3Di3.60.20.10, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR023332 Proteasome_alpha-type
IPR035144 Proteasome_alpha1
IPR000426 Proteasome_asu_N
IPR001353 Proteasome_sua/b
PANTHERiPTHR11599:SF12 PTHR11599:SF12, 1 hit
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PF10584 Proteasome_A_N, 1 hit
SMARTiView protein in SMART
SM00948 Proteasome_A_N, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS00388 PROTEASOME_ALPHA_1, 1 hit
PS51475 PROTEASOME_ALPHA_2, 1 hit

Sequencei

Sequence statusi: Complete.

P52428-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRNQYDTDV TTWSPAGRLF QVEYAMEAVK QGSACVGLRS RTHAVLAAAN
60 70 80 90 100
KAASELSSHQ RKVFRVADHA GVALAGLTAD GRVLSRFLRS ECINHAFVYD
110 120 130 140 150
APLPVSRLAL RLADKAQVCT QRSWKRPYGV GLLVAGLDES GAHLYYNCPS
160 170 180 190 200
GNYFEYQAFA IGSRSQAAKT FLERRFEGYN DYTPEQLIKD ALSAIKETLQ
210 220 230 240 250
GEKLTSSNCT VAIVGRKDDG TVEPFEMIDV KRIQEIIDSM EAAEEAPAAE
260 270
AESSSMQEED KGTDAAPMDI
Length:270
Mass (Da):29,630
Last modified:October 1, 1996 - v1
Checksum:i37954184C6588900
GO

Sequence cautioni

The sequence BAD08003 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD10085 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D37886 mRNA Translation: BAA07128.1
AP004799 Genomic DNA Translation: BAD10085.1 Different initiation.
AP004997 Genomic DNA Translation: BAD08003.1 Different initiation.
AP008208 Genomic DNA Translation: BAF07722.1
AP014958 Genomic DNA Translation: BAS76843.1
CM000139 Genomic DNA Translation: EEE56253.1
AK103646 mRNA Translation: BAG96186.1
AK109376 mRNA Translation: BAG98703.1
PIRiT03925
RefSeqiXP_015626959.1, XM_015771473.1
UniGeneiOs.12193

Genome annotation databases

EnsemblPlantsiOs02t0133800-01; Os02t0133800-01; Os02g0133800
GeneIDi4328215
GrameneiOs02t0133800-01; Os02t0133800-01; Os02g0133800
KEGGiosa:4328215

Similar proteinsi

Entry informationi

Entry nameiPSA1_ORYSJ
AccessioniPrimary (citable) accession number: P52428
Secondary accession number(s): Q0E466, Q6Z6I2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

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