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P52428

- PSA1_ORYSJ

UniProt

P52428 - PSA1_ORYSJ

Protein

Proteasome subunit alpha type-1

Gene

PAF1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

    Catalytic activityi

    Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

    GO - Molecular functioni

    1. threonine-type endopeptidase activity Source: UniProtKB-KW

    GO - Biological processi

    1. response to arsenic-containing substance Source: EnsemblPlants/Gramene
    2. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Threonine protease

    Enzyme and pathway databases

    ReactomeiREACT_205610. Cross-presentation of soluble exogenous antigens (endosomes).
    REACT_205939. Autodegradation of the E3 ubiquitin ligase COP1.
    REACT_207219. APC/C:Cdc20 mediated degradation of Securin.
    REACT_212204. Separation of Sister Chromatids.
    REACT_214064. ER-Phagosome pathway.
    REACT_219834. AUF1 (hnRNP D0) destabilizes mRNA.
    REACT_223172. Antigen processing: Ubiquitination & Proteasome degradation.

    Protein family/group databases

    MEROPSiT01.976.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proteasome subunit alpha type-1 (EC:3.4.25.1)
    Alternative name(s):
    20S proteasome alpha subunit F
    20S proteasome subunit alpha-6
    Proteasome component C2
    Gene namesi
    Name:PAF1
    Ordered Locus Names:Os02g0133800, LOC_Os02g04100
    ORF Names:P0030G11.18, P0585B01.3
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 2

    Organism-specific databases

    GrameneiP52428.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytosol Source: EnsemblPlants/Gramene
    2. nucleus Source: UniProtKB-SubCell
    3. plasma membrane Source: EnsemblPlants/Gramene
    4. plasmodesma Source: EnsemblPlants/Gramene
    5. proteasome core complex, alpha-subunit complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Proteasome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 270270Proteasome subunit alpha type-1PRO_0000124074Add
    BLAST

    Proteomic databases

    PaxDbiP52428.
    PRIDEiP52428.

    Interactioni

    Subunit structurei

    The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP52428.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase T1A family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0638.
    HOGENOMiHOG000091080.
    KOiK02725.
    OMAiFMKQQCL.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    InterProiIPR029055. Ntn_hydrolases_N.
    IPR000426. Proteasome_asu_N.
    IPR023332. Proteasome_suA-type.
    IPR001353. Proteasome_sua/b.
    [Graphical view]
    PfamiPF00227. Proteasome. 1 hit.
    PF10584. Proteasome_A_N. 1 hit.
    [Graphical view]
    SMARTiSM00948. Proteasome_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    PROSITEiPS00388. PROTEASOME_ALPHA_1. 1 hit.
    PS51475. PROTEASOME_ALPHA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P52428-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFRNQYDTDV TTWSPAGRLF QVEYAMEAVK QGSACVGLRS RTHAVLAAAN    50
    KAASELSSHQ RKVFRVADHA GVALAGLTAD GRVLSRFLRS ECINHAFVYD 100
    APLPVSRLAL RLADKAQVCT QRSWKRPYGV GLLVAGLDES GAHLYYNCPS 150
    GNYFEYQAFA IGSRSQAAKT FLERRFEGYN DYTPEQLIKD ALSAIKETLQ 200
    GEKLTSSNCT VAIVGRKDDG TVEPFEMIDV KRIQEIIDSM EAAEEAPAAE 250
    AESSSMQEED KGTDAAPMDI 270
    Length:270
    Mass (Da):29,630
    Last modified:October 1, 1996 - v1
    Checksum:i37954184C6588900
    GO

    Sequence cautioni

    The sequence BAD08003.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAD10085.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D37886 mRNA. Translation: BAA07128.1.
    AP004799 Genomic DNA. Translation: BAD10085.1. Different initiation.
    AP004997 Genomic DNA. Translation: BAD08003.1. Different initiation.
    PIRiT03925.
    RefSeqiNP_001045808.1. NM_001052343.1.
    UniGeneiOs.12193.

    Genome annotation databases

    EnsemblPlantsiOS02T0133800-01; OS02T0133800-01; OS02G0133800.
    GeneIDi4328215.
    KEGGiosa:4328215.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D37886 mRNA. Translation: BAA07128.1 .
    AP004799 Genomic DNA. Translation: BAD10085.1 . Different initiation.
    AP004997 Genomic DNA. Translation: BAD08003.1 . Different initiation.
    PIRi T03925.
    RefSeqi NP_001045808.1. NM_001052343.1.
    UniGenei Os.12193.

    3D structure databases

    ProteinModelPortali P52428.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi T01.976.

    Proteomic databases

    PaxDbi P52428.
    PRIDEi P52428.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi OS02T0133800-01 ; OS02T0133800-01 ; OS02G0133800 .
    GeneIDi 4328215.
    KEGGi osa:4328215.

    Organism-specific databases

    Gramenei P52428.

    Phylogenomic databases

    eggNOGi COG0638.
    HOGENOMi HOG000091080.
    KOi K02725.
    OMAi FMKQQCL.

    Enzyme and pathway databases

    Reactomei REACT_205610. Cross-presentation of soluble exogenous antigens (endosomes).
    REACT_205939. Autodegradation of the E3 ubiquitin ligase COP1.
    REACT_207219. APC/C:Cdc20 mediated degradation of Securin.
    REACT_212204. Separation of Sister Chromatids.
    REACT_214064. ER-Phagosome pathway.
    REACT_219834. AUF1 (hnRNP D0) destabilizes mRNA.
    REACT_223172. Antigen processing: Ubiquitination & Proteasome degradation.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    InterProi IPR029055. Ntn_hydrolases_N.
    IPR000426. Proteasome_asu_N.
    IPR023332. Proteasome_suA-type.
    IPR001353. Proteasome_sua/b.
    [Graphical view ]
    Pfami PF00227. Proteasome. 1 hit.
    PF10584. Proteasome_A_N. 1 hit.
    [Graphical view ]
    SMARTi SM00948. Proteasome_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    PROSITEi PS00388. PROTEASOME_ALPHA_1. 1 hit.
    PS51475. PROTEASOME_ALPHA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular and biochemical characterization of a proteasome subunit from rice and carrot cells."
      Umeda M., Fujii N., Manabe Y., Uchimiya H.
      Mol. Gen. Genet. 255:19-27(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.

    Entry informationi

    Entry nameiPSA1_ORYSJ
    AccessioniPrimary (citable) accession number: P52428
    Secondary accession number(s): Q6Z6I2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3