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P52428

- PSA1_ORYSJ

UniProt

P52428 - PSA1_ORYSJ

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Protein

Proteasome subunit alpha type-1

Gene

PAF1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

  1. threonine-type endopeptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiREACT_205610. Cross-presentation of soluble exogenous antigens (endosomes).
REACT_205939. Autodegradation of the E3 ubiquitin ligase COP1.
REACT_207219. APC/C:Cdc20 mediated degradation of Securin.
REACT_212204. Separation of Sister Chromatids.
REACT_214064. ER-Phagosome pathway.
REACT_219834. AUF1 (hnRNP D0) destabilizes mRNA.
REACT_223172. Antigen processing: Ubiquitination & Proteasome degradation.

Protein family/group databases

MEROPSiT01.976.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alpha type-1 (EC:3.4.25.1)
Alternative name(s):
20S proteasome alpha subunit F
20S proteasome subunit alpha-6
Proteasome component C2
Gene namesi
Name:PAF1
Ordered Locus Names:Os02g0133800, LOC_Os02g04100
ORF Names:P0030G11.18, P0585B01.3
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 2

Organism-specific databases

GrameneiP52428.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
  3. proteasome core complex, alpha-subunit complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 270270Proteasome subunit alpha type-1PRO_0000124074Add
BLAST

Proteomic databases

PaxDbiP52428.
PRIDEiP52428.

Expressioni

Gene expression databases

ExpressionAtlasiP52428. baseline.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP52428.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0638.
HOGENOMiHOG000091080.
InParanoidiP52428.
KOiK02725.
OMAiFMKQQCL.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTiSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52428 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFRNQYDTDV TTWSPAGRLF QVEYAMEAVK QGSACVGLRS RTHAVLAAAN
60 70 80 90 100
KAASELSSHQ RKVFRVADHA GVALAGLTAD GRVLSRFLRS ECINHAFVYD
110 120 130 140 150
APLPVSRLAL RLADKAQVCT QRSWKRPYGV GLLVAGLDES GAHLYYNCPS
160 170 180 190 200
GNYFEYQAFA IGSRSQAAKT FLERRFEGYN DYTPEQLIKD ALSAIKETLQ
210 220 230 240 250
GEKLTSSNCT VAIVGRKDDG TVEPFEMIDV KRIQEIIDSM EAAEEAPAAE
260 270
AESSSMQEED KGTDAAPMDI
Length:270
Mass (Da):29,630
Last modified:October 1, 1996 - v1
Checksum:i37954184C6588900
GO

Sequence cautioni

The sequence BAD08003.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAD10085.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D37886 mRNA. Translation: BAA07128.1.
AP004799 Genomic DNA. Translation: BAD10085.1. Different initiation.
AP004997 Genomic DNA. Translation: BAD08003.1. Different initiation.
PIRiT03925.
RefSeqiNP_001045808.1. NM_001052343.1.
UniGeneiOs.12193.

Genome annotation databases

EnsemblPlantsiOS02T0133800-01; OS02T0133800-01; OS02G0133800.
GeneIDi4328215.
KEGGiosa:4328215.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D37886 mRNA. Translation: BAA07128.1 .
AP004799 Genomic DNA. Translation: BAD10085.1 . Different initiation.
AP004997 Genomic DNA. Translation: BAD08003.1 . Different initiation.
PIRi T03925.
RefSeqi NP_001045808.1. NM_001052343.1.
UniGenei Os.12193.

3D structure databases

ProteinModelPortali P52428.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi T01.976.

Proteomic databases

PaxDbi P52428.
PRIDEi P52428.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi OS02T0133800-01 ; OS02T0133800-01 ; OS02G0133800 .
GeneIDi 4328215.
KEGGi osa:4328215.

Organism-specific databases

Gramenei P52428.

Phylogenomic databases

eggNOGi COG0638.
HOGENOMi HOG000091080.
InParanoidi P52428.
KOi K02725.
OMAi FMKQQCL.

Enzyme and pathway databases

Reactomei REACT_205610. Cross-presentation of soluble exogenous antigens (endosomes).
REACT_205939. Autodegradation of the E3 ubiquitin ligase COP1.
REACT_207219. APC/C:Cdc20 mediated degradation of Securin.
REACT_212204. Separation of Sister Chromatids.
REACT_214064. ER-Phagosome pathway.
REACT_219834. AUF1 (hnRNP D0) destabilizes mRNA.
REACT_223172. Antigen processing: Ubiquitination & Proteasome degradation.

Gene expression databases

ExpressionAtlasi P52428. baseline.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
InterProi IPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view ]
Pfami PF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view ]
SMARTi SM00948. Proteasome_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
PROSITEi PS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular and biochemical characterization of a proteasome subunit from rice and carrot cells."
    Umeda M., Fujii N., Manabe Y., Uchimiya H.
    Mol. Gen. Genet. 255:19-27(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.

Entry informationi

Entry nameiPSA1_ORYSJ
AccessioniPrimary (citable) accession number: P52428
Secondary accession number(s): Q6Z6I2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3