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P52425 (GPDA_CUPLA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycerol-3-phosphate dehydrogenase [NAD(+)]

EC=1.1.1.8
Gene names
Name:GPDH
OrganismCuphea lanceolata (Cigar flower)
Taxonomic identifier3930 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsMyrtalesLythraceaeCuphea

Protein attributes

Sequence length372 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

Sequence similarities

Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 372372Glycerol-3-phosphate dehydrogenase [NAD(+)]
PRO_0000138071

Regions

Nucleotide binding29 – 346NAD By similarity
Region289 – 2902Substrate binding By similarity

Sites

Active site2251Proton acceptor By similarity
Binding site601NAD By similarity
Binding site1171NAD By similarity
Binding site1401NAD; via amide nitrogen By similarity
Binding site1401Substrate By similarity
Binding site1731NAD; via amide nitrogen By similarity
Binding site2891NAD By similarity
Binding site3181NAD; via amide nitrogen By similarity
Binding site3201NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
P52425 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 1BF91793CDC23AA9

FASTA37240,811
        10         20         30         40         50         60 
MAPSELNCTH QNQHSSGYDG PRSRVTVVGS GNWGSVAAKL IATNTLKLPS FHDEVRMWVF 

        70         80         90        100        110        120 
EETLPSGEKL TDVINQTNEN VKYLPGIKLG RNVVADPDLE NAVKDANMLV FVTPHQFMEG 

       130        140        150        160        170        180 
ICKRLEGKIQ EGAQALSLIK GMEVKMEGPC MISSLISDLL GINCCVLMGA NIANEIAVEK 

       190        200        210        220        230        240 
FSEATVGFRE NRDIAEKWVQ LFSTPYFMVS AVEDVEGVEL CGTLKNIVAI AAGFVDGLEM 

       250        260        270        280        290        300 
GNNTKAAIMR IGLREMKAFS KLLFPSVKDT TFFESCGVAD LITTCLGGRN RKVAEAFAKN 

       310        320        330        340        350        360 
GGKRSFDDLE AEMLRGQKLQ GVSTAKEVYE VLGHRGWLEL FPLFSTVHEI STGRLPPSAI 

       370 
VEYSEQKTIF SW 

« Hide

References

[1]"Cloning of a cDNA coding for a glycerol-3-phosphate dehydrogenase from Cuphea lanceolata."
Hausmann L., Schell J., Toepfer R.
(In) Kader J.-C., Mazliak P. (eds.); Plant lipid metabolism, pp.534-536, Kluwer Academic Publishers, Dordrecht (1995)
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X79677 mRNA. Translation: CAA56125.1.

3D structure databases

ProteinModelPortalP52425.
SMRP52425. Positions 23-364.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11728. PTHR11728. 1 hit.
PfamPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSPR00077. GPDHDRGNASE.
SUPFAMSSF48179. SSF48179. 1 hit.
TIGRFAMsTIGR03376. glycerol3P_DH. 1 hit.
PROSITEPS00957. NAD_G3PDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGPDA_CUPLA
AccessionPrimary (citable) accession number: P52425
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 19, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families