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P52425

- GPDA_CUPLA

UniProt

P52425 - GPDA_CUPLA

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Protein

Glycerol-3-phosphate dehydrogenase [NAD(+)]

Gene

GPDH

Organism
Cuphea lanceolata (Cigar flower)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei60 – 601NADBy similarity
Binding sitei117 – 1171NADBy similarity
Binding sitei140 – 1401NAD; via amide nitrogenBy similarity
Binding sitei140 – 1401SubstrateBy similarity
Binding sitei173 – 1731NAD; via amide nitrogenBy similarity
Active sitei225 – 2251Proton acceptorBy similarity
Binding sitei289 – 2891NADBy similarity
Binding sitei318 – 3181NAD; via amide nitrogenBy similarity
Binding sitei320 – 3201NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi29 – 346NADBy similarity

GO - Molecular functioni

  1. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: UniProtKB-EC
  2. NAD binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. glycerol-3-phosphate catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(+)] (EC:1.1.1.8)
Gene namesi
Name:GPDH
OrganismiCuphea lanceolata (Cigar flower)
Taxonomic identifieri3930 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsMyrtalesLythraceaeCuphea

Subcellular locationi

GO - Cellular componenti

  1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 372372Glycerol-3-phosphate dehydrogenase [NAD(+)]PRO_0000138071Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP52425.
SMRiP52425. Positions 23-364.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni289 – 2902Substrate bindingBy similarity

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.
PROSITEiPS00957. NAD_G3PDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52425-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPSELNCTH QNQHSSGYDG PRSRVTVVGS GNWGSVAAKL IATNTLKLPS
60 70 80 90 100
FHDEVRMWVF EETLPSGEKL TDVINQTNEN VKYLPGIKLG RNVVADPDLE
110 120 130 140 150
NAVKDANMLV FVTPHQFMEG ICKRLEGKIQ EGAQALSLIK GMEVKMEGPC
160 170 180 190 200
MISSLISDLL GINCCVLMGA NIANEIAVEK FSEATVGFRE NRDIAEKWVQ
210 220 230 240 250
LFSTPYFMVS AVEDVEGVEL CGTLKNIVAI AAGFVDGLEM GNNTKAAIMR
260 270 280 290 300
IGLREMKAFS KLLFPSVKDT TFFESCGVAD LITTCLGGRN RKVAEAFAKN
310 320 330 340 350
GGKRSFDDLE AEMLRGQKLQ GVSTAKEVYE VLGHRGWLEL FPLFSTVHEI
360 370
STGRLPPSAI VEYSEQKTIF SW
Length:372
Mass (Da):40,811
Last modified:October 1, 1996 - v1
Checksum:i1BF91793CDC23AA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79677 mRNA. Translation: CAA56125.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79677 mRNA. Translation: CAA56125.1 .

3D structure databases

ProteinModelPortali P52425.
SMRi P52425. Positions 23-364.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11728. PTHR11728. 1 hit.
Pfami PF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSi PR00077. GPDHDRGNASE.
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR03376. glycerol3P_DH. 1 hit.
PROSITEi PS00957. NAD_G3PDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of a cDNA coding for a glycerol-3-phosphate dehydrogenase from Cuphea lanceolata."
    Hausmann L., Schell J., Toepfer R.
    (In) Kader J.-C., Mazliak P. (eds.); Plant lipid metabolism, pp.534-536, Kluwer Academic Publishers, Dordrecht (1995)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiGPDA_CUPLA
AccessioniPrimary (citable) accession number: P52425
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 1, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3