Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P52424 (PUR5_VIGUN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoribosylformylglycinamidine cyclo-ligase, chloroplastic/mitochondrial

EC=6.3.3.1
Alternative name(s):
AIR synthase
Short name=AIRS
Phosphoribosyl-aminoimidazole synthetase
VUpur5
Gene names
Name:PUR5
OrganismVigna unguiculata (Cowpea)
Taxonomic identifier3917 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeVigna

Protein attributes

Sequence length388 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.

Subcellular location

Plastidchloroplast. Mitochondrion.

Sequence similarities

Belongs to the AIR synthase family.

Ontologies

Keywords
   Biological processPurine biosynthesis
   Cellular componentChloroplast
Mitochondrion
Plastid
   DomainTransit peptide
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
Gene Ontology (GO)
   Biological_process'de novo' IMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentchloroplast

Inferred from electronic annotation. Source: UniProtKB-SubCell

mitochondrion

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoribosylformylglycinamidine cyclo-ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Chloroplast and mitochondrion Potential
Chain? – 388Phosphoribosylformylglycinamidine cyclo-ligase, chloroplastic/mitochondrialPRO_0000029882

Sequences

Sequence LengthMass (Da)Tools
P52424 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 15D0EF11127C9EE6

FASTA38840,427
        10         20         30         40         50         60 
MSLSACAELS RCFAAAASAK PNSGKSNSTA ATSLVISSPI GHDGAVSSVS RSRKTSRIVA 

        70         80         90        100        110        120 
EASQGLTYRD AGVDIDAGAE LVRRIAKMAP GIGGFGGLYP LGDSYLVAGT DGVGTKLMLA 

       130        140        150        160        170        180 
FETGIHDTIG IDLVAMSVND IVTSGAKPLF FLDYFATGRL DVDVAEKVVK GIVDGCKQSD 

       190        200        210        220        230        240 
CVLLGGETAE MPGLYKEGEY DLSGCAVGIV KKDSVINGKN IVAGDVIIGL PSSGVHSNGF 

       250        260        270        280        290        300 
SLVRRVLAQS GLSLKDQLPG SNITLAEALM APTVIYVKQV LDLISKGGVK GIAHITGGGF 

       310        320        330        340        350        360 
TDNIPRVFPE GLGALIYDGS WEVPAVFRWL QEAGKIEDSE MRRTFNMGIG MILVVSPEAA 

       370        380 
NRILENKGQA DKFYRIGEII SGNGVTFS 

« Hide

References

[1]"AIR synthetase in cowpea nodules: a single gene product targeted to two organelles?"
Smith P.M.C., Mann A.J., Goggin D.E., Atkins C.A.
Plant Mol. Biol. 36:811-820(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Vita 3.
Tissue: Root nodule.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U30895 mRNA. Translation: AAC14578.1.
PIRT10963.

3D structure databases

ProteinModelPortalP52424.
SMRP52424. Positions 76-388.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

ProMEXP52424.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BRENDA6.3.3.1. 6657.
UniPathwayUPA00074; UER00129.

Family and domain databases

Gene3D3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
InterProIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsTIGR00878. purM. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR5_VIGUN
AccessionPrimary (citable) accession number: P52424
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways