P52415 (GLGC_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-1-phosphate adenylyltransferase
EC=2.7.7.27

Alternative name(s):
ADP-glucose pyrophosphorylase
Short name=ADPGlc PPase
ADP-glucose synthase

Gene names

Name:	glgC
Synonyms:	agp
Ordered Locus Names:	slr1176

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa)

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechocystis

Protein attributes

Sequence length	439 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans By similarity. HAMAP MF_00624
Catalytic activity	ATP + alpha-D-glucose 1-phosphate = diphosphate + ADP-glucose. HAMAP MF_00624
Pathway	Glycan biosynthesis; glycogen biosynthesis. HAMAP MF_00624
Subunit structure	Homotetramer.
Sequence similarities	Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glycogen biosynthesis Glycogen metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glycogen biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW glucose-1-phosphate adenylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
trxA	P52231	1	EBI-865829,EBI-862916

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 439	439	Glucose-1-phosphate adenylyltransferase HAMAP MF_00624		PRO_0000195338
Experimental info
	Sequence conflict	196	1	A → G in AAA27275. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P52415 [UniParc]. Last modified November 1, 1997. Version 2. Checksum: 018BED2B72F9EB93	FASTA	439	49,366
	10 20 30 40 50 60 MCCWQSRGLL VKRVLAIILG GGAGTRLYPL TKLRAKPAVP LAGKYRLIDI PVSNCINSEI 70 80 90 100 110 120 VKIYVLTQFN SASLNRHISR AYNFSGFQEG FVEVLAAQQT KDNPDWFQGT ADAVRQYLWL 130 140 150 160 170 180 FREWDVDEYL ILSGDHLYRM DYAQFVKRHR ETNADITLSV VPVDDRKAPE LGLMKIDAQG 190 200 210 220 230 240 RITDFSEKPQ GEALRAMQVD TSVLGLSAEK AKLNPYIASM GIYVFKKEVL HNLLEKYEGA 250 260 270 280 290 300 TDFGKEIIPD SASDHNLQAY LFDDYWEDIG TIEAFYEANL ALTKQPSPDF SFYNEKAPIY 310 320 330 340 350 360 TRGRYLPPTK MLNSTVTESM IGEGCMIKQC RIHHSVLGIR SRIESDCTIE DTLVMGNDFY 370 380 390 400 410 420 ESSSERDTLK ARGEIAAGIG SGTTIRRAII DKNARIGKNV MIVNKENVQE ANREELGFYI 430 RNGIVVVIKN VTIADGTVI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27184 / PCC 6803 / N-1.
[2]	Kakefuda G., Charng Y.Y., Iglesias A.A., McIntosh L., Preiss J. Submitted (FEB-1992) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 11-439.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000022 Genomic DNA. Translation: BAA18822.1. M83556 Genomic DNA. Translation: AAA27275.1.
PIR	S76910.
RefSeq	NP_443010.1. NC_000911.1.
3D structure databases
ProteinModelPortal	P52415.
SMR	P52415. Positions 12-439.
ModBase	Search...
Protein-protein interaction databases
IntAct	P52415. 4 interactions.
STRING	P52415.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	951909.
GenomeReviews	Gene locus slr1176 in contig BA000022_GR.
KEGG	syn:slr1176.
NMPDR	fig|1148.1.peg.3111.
PATRIC	23843870. VBISynSp132158_3465.
Phylogenomic databases
eggNOG	COG0448.
HOGENOM	HBG703946.
OMA	LMGADFY.
PhylomeDB	P52415.
ProtClustDB	PRK02862.
Enzyme and pathway databases
BioCyc	SSP1148:SLR1176-MONOMER.
BRENDA	2.7.7.27. 6185.
Family and domain databases
HAMAP	MF_00624. GlgC. [Tree]
InterPro	IPR005836. ADP_Glu_pyroP_CS. IPR011831. GlgC. IPR023049. GlgC_bac. IPR005835. NTP_transferase. IPR011004. Trimer_LpxA-like. [Graphical view]
KO	K00975.
Pfam	PF00483. NTP_transferase. 1 hit. [Graphical view]
SUPFAM	SSF51161. Trimer_LpxA_like. 1 hit.
TIGRFAMs	TIGR02091. GlgC. 1 hit.
PROSITE	PS00808. ADP_GLC_PYROPHOSPH_1. 1 hit. PS00809. ADP_GLC_PYROPHOSPH_2. 1 hit. PS00810. ADP_GLC_PYROPHOSPH_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLGC_SYNY3

Accession

Primary (citable) accession number: P52415
Secondary accession number(s): P74703

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	November 1, 1997
Last modified:	January 25, 2012
This is version 73 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program