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Protein

3-oxoacyl-[acyl-carrier-protein] synthase I, chloroplastic

Gene

KAS1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids (By similarity).By similarity

Catalytic activityi

Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei224PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciARA:AT5G46290-MONOMER
MetaCyc:AT5G46290-MONOMER
BRENDAi2.3.1.41 399

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] synthase I, chloroplastic (EC:2.3.1.41)
Alternative name(s):
Beta-ketoacyl-ACP synthase I
Short name:
KAS I
Gene namesi
Name:KAS1
Ordered Locus Names:At5g46290
ORF Names:MPL12.7
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G46290

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 46ChloroplastSequence analysisAdd BLAST46
ChainiPRO_000000058647 – 4733-oxoacyl-[acyl-carrier-protein] synthase I, chloroplasticAdd BLAST427

Proteomic databases

PaxDbiP52410
PRIDEiP52410

Expressioni

Gene expression databases

ExpressionAtlasiP52410 baseline and differential
GenevisibleiP52410 AT

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi3702.AT5G46290.3

Structurei

3D structure databases

ProteinModelPortaliP52410
SMRiP52410
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-ketoacyl-ACP synthases family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1394 Eukaryota
COG0304 LUCA
HOGENOMiHOG000060166
InParanoidiP52410
KOiK09458
PhylomeDBiP52410

Family and domain databases

Gene3Di3.40.47.10, 2 hits
InterProiView protein in InterPro
IPR017568 3-oxoacyl-ACP_synth-2
IPR018201 Ketoacyl_synth_AS
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR016039 Thiolase-like
PfamiView protein in Pfam
PF00109 ketoacyl-synt, 1 hit
PF02801 Ketoacyl-synt_C, 1 hit
SMARTiView protein in SMART
SM00825 PKS_KS, 1 hit
SUPFAMiSSF53901 SSF53901, 2 hits
TIGRFAMsiTIGR03150 fabF, 1 hit
PROSITEiView protein in PROSITE
PS00606 B_KETOACYL_SYNTHASE, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P52410-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQALQSSSLR ASPPNPLRLP SNRQSHQLIT NARPLRRQQR SFISASASTV
60 70 80 90 100
SAPKRETDPK KRVVITGMGL VSVFGNDVDA YYEKLLSGES GISLIDRFDA
110 120 130 140 150
SKFPTRFGGQ IRGFSSEGYI DGKNERRLDD CLKYCIVAGK KALESANLGG
160 170 180 190 200
DKLNTIDKRK AGVLVGTGMG GLTVFSEGVQ NLIEKGHRRI SPFFIPYAIT
210 220 230 240 250
NMGSALLAID LGLMGPNYSI STACATSNYC FYAAANHIRR GEADMMIAGG
260 270 280 290 300
TEAAIIPIGL GGFVACRALS QRNDDPQTAS RPWDKARDGF VMGEGAGVLV
310 320 330 340 350
MESLEHAMKR GAPIVAEYLG GAVNCDAHHM TDPRADGLGV SSCIERCLED
360 370 380 390 400
AGVSPEEVNY INAHATSTLA GDLAEINAIK KVFKSTSGIK INATKSMIGH
410 420 430 440 450
CLGAAGGLEA IATVKAINTG WLHPSINQFN PEQAVDFDTV PNEKKQHEVD
460 470
VAISNSFGFG GHNSVVAFSA FKP
Length:473
Mass (Da):50,413
Last modified:March 27, 2002 - v2
Checksum:i38CA54382419411C
GO
Isoform 2 (identifier: P52410-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     198-252: Missing.

Show »
Length:418
Mass (Da):44,730
Checksum:i1B656C5985A93752
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti74F → C in AAC49118 (Ref. 1) Curated1
Sequence conflicti238 – 239IR → NH in AAC49118 (Ref. 1) Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_040746198 – 252Missing in isoform 2. CuratedAdd BLAST55

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24177 mRNA Translation: AAC49118.1
AB010698 Genomic DNA Translation: BAB11084.1
CP002688 Genomic DNA Translation: AED95363.1
CP002688 Genomic DNA Translation: AED95364.1
AY037261 mRNA Translation: AAK59862.1
AY094005 mRNA Translation: AAM16266.1
AY123979 mRNA Translation: AAM74493.1
AY087843 mRNA Translation: AAM65396.1
RefSeqiNP_001032018.1, NM_001036941.1 [P52410-2]
NP_199441.1, NM_123998.3 [P52410-1]
UniGeneiAt.9183

Genome annotation databases

EnsemblPlantsiAT5G46290.1; AT5G46290.1; AT5G46290 [P52410-1]
AT5G46290.2; AT5G46290.2; AT5G46290 [P52410-2]
GeneIDi834671
GrameneiAT5G46290.1; AT5G46290.1; AT5G46290 [P52410-1]
AT5G46290.2; AT5G46290.2; AT5G46290 [P52410-2]
KEGGiath:AT5G46290

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiKASC1_ARATH
AccessioniPrimary (citable) accession number: P52410
Secondary accession number(s): Q2V312, Q9FL32
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: March 27, 2002
Last modified: April 25, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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