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Protein

Glucan endo-1,3-beta-glucosidase

Gene

GLC1

Organism
Triticum aestivum (Wheat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Is thought to be an important plant defense-related product against fungal pathogens.

Catalytic activityi

Hydrolysis of (1->3)-beta-D-glucosidic linkages in (1->3)-beta-D-glucans.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei265 – 2651NucleophileBy similarity
Active sitei328 – 3281Proton donorBy similarity

GO - Molecular functioni

  1. glucan endo-1,3-beta-D-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. defense response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Plant defense

Protein family/group databases

CAZyiCBM43. Carbohydrate-Binding Module Family 43.
GH17. Glycoside Hydrolase Family 17.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucan endo-1,3-beta-glucosidase (EC:3.2.1.39)
Alternative name(s):
(1->3)-beta-glucan endohydrolase
Short name:
(1->3)-beta-glucanase
Beta-1,3-endoglucanase
Gene namesi
Name:GLC1
OrganismiTriticum aestivum (Wheat)
Taxonomic identifieri4565 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladePooideaeTriticeaeTriticum
ProteomesiUP000019116: Unplaced

Organism-specific databases

GrameneiP52409.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 461438Glucan endo-1,3-beta-glucosidasePRO_0000011881Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi378 ↔ 439By similarity

Post-translational modificationi

Contains two additional disulfide bonds.By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Inductioni

Associated with aluminum toxicity.

Structurei

3D structure databases

ProteinModelPortaliP52409.
SMRiP52409. Positions 367-461.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 17 family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR000490. Glyco_hydro_17.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR012946. X8.
[Graphical view]
PfamiPF00332. Glyco_hydro_17. 1 hit.
PF07983. X8. 1 hit.
[Graphical view]
SMARTiSM00768. X8. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00587. GLYCOSYL_HYDROL_F17. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52409-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPLLILLMLL AAGAAGAESA TPSLHIGVNY GANADNLPSP TSVATFLATK
60 70 80 90 100
TTIDRVKLFD ANPTFISAFA GTPISLAVSL PNSALPALAD KATGLDAARS
110 120 130 140 150
WIRANLSPYV PATNVTLLLA GNEILLSTDT NLILSLLPAM RRLAQALKAE
160 170 180 190 200
GLTGVRVTTP HYLGILAPSD GIPSNASFRA GYNTKLFPAM LQFHRDTGSP
210 220 230 240 250
FMVNPYPYFS YRPETLNYAL FRPNSGIYDP ATKLNYTSML DAQMDAIYTA
260 270 280 290 300
MKKLGYGDVD IAVGEAGWPT QAEPGQIGVG VQEARDFNEG MIRVCSSGKG
310 320 330 340 350
TPLMPNRTFE TYLFSLFDEN QKPGPIAERH FGLFNPDFTP VYDLGLLRDG
360 370 380 390 400
ASVAPTPSPN PSPNPSPKPA PSGGGKWCVA KDGANGTDLQ NNINYACGFV
410 420 430 440 450
DCKPIQSGGA CFSPNSLQAH ASYVMNAYYQ ANGHTDLACD FKGTGIVTSS
460
DPSYGGCKYV S
Length:461
Mass (Da):48,873
Last modified:October 1, 1996 - v1
Checksum:i7C45F10A026C87F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U30323 mRNA. Translation: AAA90953.1.
PIRiT06268.
UniGeneiTa.55395.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U30323 mRNA. Translation: AAA90953.1.
PIRiT06268.
UniGeneiTa.55395.

3D structure databases

ProteinModelPortaliP52409.
SMRiP52409. Positions 367-461.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiCBM43. Carbohydrate-Binding Module Family 43.
GH17. Glycoside Hydrolase Family 17.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GrameneiP52409.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR000490. Glyco_hydro_17.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR012946. X8.
[Graphical view]
PfamiPF00332. Glyco_hydro_17. 1 hit.
PF07983. X8. 1 hit.
[Graphical view]
SMARTiSM00768. X8. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00587. GLYCOSYL_HYDROL_F17. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequence of cDNA for a 1,3-beta-glucanase associated with aluminum toxicity in wheat roots."
    Cruz-Ortega R.M., Cushman J.C., Ownby J.D.
    Plant Gene Register PGR95-073
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Victory.
    Tissue: Root.

Entry informationi

Entry nameiE13B_WHEAT
AccessioniPrimary (citable) accession number: P52409
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: January 7, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.