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P52389

- CDC2_VIGUN

UniProt

P52389 - CDC2_VIGUN

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Protein
Cell division control protein 2 homolog
Gene
CDC2
Organism
Vigna unguiculata (Cowpea)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Plays a key role in the control of the eukaryotic cell cycle. Component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Enzyme regulationi

Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-161 activates it By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331ATP By similarity
Active sitei127 – 1271Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC
  3. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. mitotic nuclear division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 2 homolog (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
p34cdc2
Gene namesi
Name:CDC2
OrganismiVigna unguiculata (Cowpea)
Taxonomic identifieri3917 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeVigna

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 294294Cell division control protein 2 homolog
PRO_0000085761Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei14 – 141Phosphothreonine By similarity
Modified residuei15 – 151Phosphotyrosine By similarity
Modified residuei161 – 1611Phosphothreonine; by CAK By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP52389.

Structurei

3D structure databases

ProteinModelPortaliP52389.
SMRiP52389. Positions 1-294.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 287284Protein kinase
Add
BLAST

Sequence similaritiesi

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52389-1 [UniParc]FASTAAdd to Basket

« Hide

MEQYEKVEKI GEGTYGVVYK ARDRVTDETI ALKKIRLEQE DEGVPSTAIR    50
EISLLKEMQH RNIVRLQDVV HSEKRLYLVF EYLDLDLKKH MDSSPEFVKD 100
PRQVKMFLYQ ILCGIAYCHS HRVLHRDLKP QNLLIDRRTN SLKLADFGLA 150
RAFGIPVRTF THEVVTLWYR APEILLGSRH YSTPVDVWSV GCLFAEMVNR 200
RPLFPGDSEI DELFKIFRIL GTPNEETWPG VTALPDFKST FPKWPPKDLA 250
TMVPNLDAAG LNLLSSMLSL DPSKRITARI AVEHEYFKDI KFVP 294
Length:294
Mass (Da):34,000
Last modified:October 1, 1996 - v1
Checksum:i7125CEDCD6E3E360
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X89400 mRNA. Translation: CAA61581.1.
PIRiS57928.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X89400 mRNA. Translation: CAA61581.1 .
PIRi S57928.

3D structure databases

ProteinModelPortali P52389.
SMRi P52389. Positions 1-294.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P52389.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A cDNA from Vigna unguiculata encoding the protein kinase p34cdc2."
    Krause A., el Kouaissi R., Broughton W.J.
    Plant Gene Register PGR95-076
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Red Caloona.
    Tissue: Root hair.

Entry informationi

Entry nameiCDC2_VIGUN
AccessioniPrimary (citable) accession number: P52389
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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