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P52389 (CDC2_VIGUN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cell division control protein 2 homolog

EC=2.7.11.22
EC=2.7.11.23
Alternative name(s):
p34cdc2
Gene names
Name:CDC2
OrganismVigna unguiculata (Cowpea)
Taxonomic identifier3917 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeVigna

Protein attributes

Sequence length294 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays a key role in the control of the eukaryotic cell cycle. Component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Enzyme regulation

Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-161 activates it By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 294294Cell division control protein 2 homolog
PRO_0000085761

Regions

Domain4 – 287284Protein kinase
Nucleotide binding10 – 189ATP By similarity

Sites

Active site1271Proton acceptor By similarity
Binding site331ATP By similarity

Amino acid modifications

Modified residue141Phosphothreonine By similarity
Modified residue151Phosphotyrosine By similarity
Modified residue1611Phosphothreonine; by CAK By similarity

Sequences

Sequence LengthMass (Da)Tools
P52389 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 7125CEDCD6E3E360

FASTA29434,000
        10         20         30         40         50         60 
MEQYEKVEKI GEGTYGVVYK ARDRVTDETI ALKKIRLEQE DEGVPSTAIR EISLLKEMQH 

        70         80         90        100        110        120 
RNIVRLQDVV HSEKRLYLVF EYLDLDLKKH MDSSPEFVKD PRQVKMFLYQ ILCGIAYCHS 

       130        140        150        160        170        180 
HRVLHRDLKP QNLLIDRRTN SLKLADFGLA RAFGIPVRTF THEVVTLWYR APEILLGSRH 

       190        200        210        220        230        240 
YSTPVDVWSV GCLFAEMVNR RPLFPGDSEI DELFKIFRIL GTPNEETWPG VTALPDFKST 

       250        260        270        280        290 
FPKWPPKDLA TMVPNLDAAG LNLLSSMLSL DPSKRITARI AVEHEYFKDI KFVP 

« Hide

References

[1]"A cDNA from Vigna unguiculata encoding the protein kinase p34cdc2."
Krause A., el Kouaissi R., Broughton W.J.
Plant Gene Register PGR95-076
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Red Caloona.
Tissue: Root hair.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X89400 mRNA. Translation: CAA61581.1.
PIRS57928.

3D structure databases

ProteinModelPortalP52389.
SMRP52389. Positions 1-294.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP52389.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDC2_VIGUN
AccessionPrimary (citable) accession number: P52389
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 19, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families