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Protein

Capsid vertex component 2

Gene

CVC2

Organism
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Capsid vertex-specific component that plays a role during viral DNA encapsidation, assuring correct genome cleavage and presumably stabilizing capsids that contain full-length viral genomes. Participates in the interaction between the capsid and the tegument through interaction with the large tegument protein/LTP.UniRule annotation

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Viral genome packaging, Viral penetration into host nucleus, Viral release from host cell, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Capsid vertex component 2UniRule annotation
Gene namesi
Name:CVC2UniRule annotation
ORF Names:BHRF3, U50
OrganismiHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus)
Taxonomic identifieri10370 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeRoseolovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009295 Componenti: Genome

Subcellular locationi

  • Virion UniRule annotation
  • Host nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001159981 – 555Capsid vertex component 2Add BLAST555

Interactioni

Subunit structurei

Heterodimerizes with CVC1. Interacts with major capsid protein/MCP and triplex capsid protein 1/TRX1 at the pentamer vertices. Interacts with the large tegument protein/LTP.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP52387.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 47Interaction with major capsid protein/MCPUniRule annotationAdd BLAST47

Sequence similaritiesi

Belongs to the herpesviridae CVC2 protein family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG0900005N.

Family and domain databases

HAMAPiMF_04025. HSV_CVC2. 1 hit.
InterProiView protein in InterPro
IPR002493. Herpes_UL25.
PfamiView protein in Pfam
PF01499. Herpes_UL25. 1 hit.

Sequencei

Sequence statusi: Complete.

P52387-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQCNLFYQY PITPILEGHV RNILICTEKD VEKLQSQSSL RLREKIDQGH
60 70 80 90 100
RDKLLRMRLK TELDALQKKM QKDSDVLNSH LKAIEDALLF TNDGEVNVET
110 120 130 140 150
KADAQLIPKS PEKLEKFNQV AITPLDPFIR FTDDFRGEMI NTFFNNAQMW
160 170 180 190 200
NFTFGSWFYK LKRVFYNEPG LRRALKLTNV DSLTISKELL AVTVNALEQA
210 220 230 240 250
TVYPIFGSEM SDLEAALCIL AAFYSTYENS QIDERTTLVD VITLLPVIFR
260 270 280 290 300
LLGSEITALK NVSPSGTYFG FNDPSCMKFF VPMRKGKHYA ENTFGNHVLI
310 320 330 340 350
KMLLGRGVMQ KIPGEKISQN FDVEARLHGA IKNDVLVYWT YQLMRPKLGN
360 370 380 390 400
NVPIFIHDQH YLRSGLVAIE SLFLLWRILN SESLFNKRVG KFLLTSIFPQ
410 420 430 440 450
LENVDFAENN FEAGNIQNFE YLMHHYVVPM YNLQNDISIS TLFPGLVAVC
460 470 480 490 500
VNESVRLGWE HKCAGAPSDA VQVQSKENPF VEYIRAQMEQ QADVAILEKH
510 520 530 540 550
DCILFHLENG LNITLSFTLP RQRLFAMASS LFNVNDTYDF IYFLVLGFLP

IPAVI
Length:555
Mass (Da):63,594
Last modified:October 1, 1996 - v1
Checksum:iBA0C879FF56130D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83413 Genomic DNA. Translation: CAA58384.1.
X64320 Genomic DNA. Translation: CAA45605.1.
RefSeqiNP_042943.1. NC_001664.2.

Genome annotation databases

GeneIDi1487930.
KEGGivg:1487930.

Similar proteinsi

Entry informationi

Entry nameiCVC2_HHV6U
AccessioniPrimary (citable) accession number: P52387
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 22, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families