P52381 (UL33_HHV7J) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
G-protein coupled receptor homolog U12

Gene names

Name:

U12

Organism

Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) [Complete proteome]

Taxonomic identifier

57278 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Betaherpesvirinae › Roseolovirus › Human herpesvirus 7

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location	Host cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Host cell membrane Host membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
Technical term	Complete proteome
Gene Ontology (GO)
Cellular_component	host cell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 346	346	G-protein coupled receptor homolog U12		PRO_0000070242
Regions
	Topological domain	1 – 31	31	Extracellular Potential
	Transmembrane	32 – 56	25	Helical; Name=1; Potential
	Topological domain	57 – 83	27	Cytoplasmic Potential
	Transmembrane	84 – 108	25	Helical; Name=2; Potential
	Topological domain	109 – 115	7	Extracellular Potential
	Transmembrane	116 – 142	27	Helical; Name=3; Potential
	Topological domain	143 – 159	17	Cytoplasmic Potential
	Transmembrane	160 – 181	22	Helical; Name=4; Potential
	Topological domain	182 – 208	27	Extracellular Potential
	Transmembrane	209 – 229	21	Helical; Name=5; Potential
	Topological domain	230 – 245	16	Cytoplasmic Potential
	Transmembrane	246 – 272	27	Helical; Name=6; Potential
	Topological domain	273 – 286	14	Extracellular Potential
	Transmembrane	287 – 310	24	Helical; Name=7; Potential
	Topological domain	311 – 346	36	Cytoplasmic Potential

Sequences

	Sequence		Length	Mass (Da)
	P52381 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 22CAD09206FDC331	FASTA	346	39,969
	10 20 30 40 50 60 MICYSFAKNV TFAFLIILQN FFSQHDEEYK YNYTCITPTV RKAQRLESVI NGIMLTLILP 70 80 90 100 110 120 VSTVVICTLL IYYKWTKQTI TSPYLITLFI SDSLHSLTVL LLTLNREALT NLNQALCQCV 130 140 150 160 170 180 LFVYSASCTY SLCMLAVIST IRYRTLQRRT LNDKNNNHIK RNVGILFLSS AMCAIPAVLY 190 200 210 220 230 240 VQVEKKKGNY GKCNIHISTQ KAYDLFIGIK IVYCFLWGIF PTVIFSYFYV IFGKTLRALT 250 260 270 280 290 300 QSKHNKTLSF ISLLILSFLC IQIPNLLVMS VEIFFLYIAN TSCLGTIQRE IVQIISRLMP 310 320 330 340 EIHCLSNPLV YAFTRTDFRL RFYDFIKCNL CNSSLKRKRN PLTIKN

References

[1]	Nicholas J. Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	U43400 Genomic DNA. Translation: AAC54673.1.
PIR	T41913.
3D structure databases
ProteinModelPortal	P52381.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PRIDE	P52381.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UL33_HHV7J

Accession

Primary (citable) accession number: P52381

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	January 9, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program