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Protein

Envelope glycoprotein M

Gene

gM

Organism
Equine herpesvirus 2 (strain 86/87) (EHV-2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Envelope glycoprotein important for virion assembly and egress. Plays a role in the correct incorporation of gH-gL into virion membrane. Directs the glycoprotein N (gN) to the host trans-Golgi network.UniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein MUniRule annotation
Short name:
gMUniRule annotation
Gene namesi
Name:gMUniRule annotation
ORF Names:39
OrganismiEquine herpesvirus 2 (strain 86/87) (EHV-2)
Taxonomic identifieri82831 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaePercavirus
Virus hostiEquus caballus (Horse) [TaxID: 9796]
Proteomesi
  • UP000007083 Componenti: Genome

Subcellular locationi

P52371:
  • Virion membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
  • host trans-Golgi network UniRule annotation
  • Host endosome membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
  • Host nucleus inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
  • Note: During virion morphogenesis, this protein accumulates in the trans-Golgi network where secondary envelopment occurs.UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16IntravirionUniRule annotationAdd BLAST16
Transmembranei17 – 37HelicalUniRule annotationAdd BLAST21
Topological domaini38 – 84Virion surfaceUniRule annotationAdd BLAST47
Transmembranei85 – 105HelicalUniRule annotationAdd BLAST21
Topological domaini106 – 118IntravirionUniRule annotationAdd BLAST13
Transmembranei119 – 139HelicalUniRule annotationAdd BLAST21
Topological domaini140 – 150Virion surfaceUniRule annotationAdd BLAST11
Transmembranei151 – 171HelicalUniRule annotationAdd BLAST21
Topological domaini172 – 210IntravirionUniRule annotationAdd BLAST39
Transmembranei211 – 231HelicalUniRule annotationAdd BLAST21
Topological domaini232 – 239Virion surfaceUniRule annotation8
Transmembranei240 – 260HelicalUniRule annotationAdd BLAST21
Topological domaini261 – 268IntravirionUniRule annotation8
Transmembranei269 – 289HelicalUniRule annotationAdd BLAST21
Topological domaini290 – 303Virion surfaceUniRule annotationAdd BLAST14
Transmembranei304 – 324HelicalUniRule annotationAdd BLAST21
Topological domaini325 – 378IntravirionUniRule annotationAdd BLAST54

GO - Cellular componenti

Keywords - Cellular componenti

Host endosome, Host Golgi apparatus, Host membrane, Host nucleus, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001157781 – 378Envelope glycoprotein MAdd BLAST378

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44Interchain (with gN)UniRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Interacts (via N-terminus) with gN (via N-terminus). The gM-gN heterodimer forms the gCII complex.UniRule annotation

Structurei

3D structure databases

SMRiP52371.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi373 – 377Poly-Glu5

Sequence similaritiesi

Belongs to the herpesviridae glycoprotein M family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiVOG090000D2.

Family and domain databases

HAMAPiMF_04035. HSV_GM. 1 hit.
InterProiView protein in InterPro
IPR000785. Herpes_glycop_M.
PfamiView protein in Pfam
PF01528. Herpes_glycop. 1 hit.
PRINTSiPR00333. HSVINTEGRLMP.

Sequencei

Sequence statusi: Complete.

P52371-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSSKSDLFI YKTWFKLLVL YFVMFVLSAT VPIAASFPGL GFPCYYNALV
60 70 80 90 100
NYSAINLTER NVAKHLTPTL YLEEPEMFAY MTFTFLVDCF AAVYYFLGAL
110 120 130 140 150
AIMLAKRHFV VSLTTLSQWI AMVGTPTLIL IGMWRMWTIQ LFIQTLSYKH
160 170 180 190 200
IYLSAFVYLI HFLLSFLHTQ CYISRNSQLW SLKVLEQGIP PNTLLDTVVF
210 220 230 240 250
TIKPLLANCQ LFCLGLEMLV FSLSFMMAIG NSFYVLVSDI VFGAINLYLA
260 270 280 290 300
LVLFWVLLTE LYLVKYMTFV MGFYLGGLIG CIFLLVPLWR YEQIFVAANL
310 320 330 340 350
RSPILINILV IFFLCTLSAL VRLLRMTWFS PTKPSYEPIQ LKNIKHRRVK
360 370
LQSPSGPSIL EEGSSDEGSE DSEEEEEL
Length:378
Mass (Da):43,372
Last modified:October 1, 1996 - v1
Checksum:i2D629C8B031D0533
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20824 Genomic DNA. Translation: AAC13827.1.
PIRiS55634.
RefSeqiNP_042636.1. NC_001650.2.

Genome annotation databases

GeneIDi1461035.
KEGGivg:1461035.

Similar proteinsi

Entry informationi

Entry nameiGM_EHV2
AccessioniPrimary (citable) accession number: P52371
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 15, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families