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P52362

- DEN_HHV7J

UniProt

P52362 - DEN_HHV7J

Protein

Deneddylase

Gene

U31

Organism
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Deneddylase that deregulates the host cell cycle S phase to create a favorable environment allowing efficient viral genome replication. Interacts with and deneddylates host cullins including CUL1 and CUL4A, thereby reducing their E3 ubiquitin ligase activity. Inhibition of cullins leads to the stabilization of cullin-RING ligase substrates such as host CDN1A/p21, CDKN1B/p27kip and CDC25A, preventing S phase progression. Additionally, acts as a deubiquitinase and cleaves both 'Lys-48' and 'Lys-63'-linked ubiquitin chains By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei10 – 101Important for catalytic activityPROSITE-ProRule annotation
    Active sitei23 – 231PROSITE-ProRule annotation
    Active sitei155 – 1551PROSITE-ProRule annotation
    Active sitei157 – 1571PROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW

    GO - Biological processi

    1. modulation by virus of host protein ubiquitination Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Host-virus interaction, Modulation of host ubiquitin pathway by viral deubiquitinase, Modulation of host ubiquitin pathway by virus, Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deneddylase (EC:3.4.19.12, EC:3.4.22.-)
    Alternative name(s):
    Ubiquitin thioesterase
    Gene namesi
    Name:U31
    OrganismiHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)
    Taxonomic identifieri57278 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeRoseolovirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000009246: Genome

    Subcellular locationi

    GO - Cellular componenti

    1. host cell cytoplasm Source: UniProtKB-SubCell
    2. host cell nucleus Source: UniProtKB-SubCell
    3. viral tegument Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cytoplasm, Host nucleus, Virion, Virion tegument

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 20592059DeneddylasePRO_0000116042Add
    BLAST

    Proteomic databases

    PRIDEiP52362.

    Interactioni

    Subunit structurei

    Interacts with host CUL1 and CUL4A; these interactions inhibit the E3 ligase activity of cullins.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP52362.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 220218Peptidase C76PROSITE-ProRule annotationAdd
    BLAST
    Repeati273 – 29725LRR 1Add
    BLAST
    Repeati536 – 55924LRR 2Add
    BLAST
    Repeati714 – 74128LRR 3Add
    BLAST
    Repeati747 – 77024LRR 4Add
    BLAST
    Repeati852 – 87524LRR 5Add
    BLAST
    Repeati969 – 99123LRR 6Add
    BLAST
    Repeati1525 – 154723LRR 7Add
    BLAST
    Repeati1624 – 164017LRR 8Add
    BLAST
    Repeati1641 – 166525LRR 9Add
    BLAST
    Repeati1678 – 170124LRR 10Add
    BLAST
    Repeati1718 – 174124LRR 11Add
    BLAST
    Repeati1828 – 185225LRR 12Add
    BLAST
    Repeati1978 – 200225LRR 13Add
    BLAST
    Repeati2027 – 204923LRR 14Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1103 – 114038Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the herpesviridae deneddylase family.Curated
    Contains 14 LRR (leucine-rich) repeats.Curated
    Contains 1 peptidase C76 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Leucine-rich repeat, Repeat

    Family and domain databases

    InterProiIPR006928. Pept_C76_UL36-USP.
    [Graphical view]
    PfamiPF04843. Herpes_teg_N. 1 hit.
    [Graphical view]
    PROSITEiPS51521. HTUSP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P52362-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRIIAGSTNQ NDPKYGPRAG KQCMSNCFSF LHTVYLNGIN NVLNKESIDI     50
    IMENGALLDN ISTTTLKLET GNIPEYRFFT EIPKKISSNF GETIHELSRP 100
    FNGTLESQHI DNEVYLGLLD FLLYGKNKKP AFIVITIGVM ARAIFIVDEL 150
    FYLFDSHASD TENSAAIYIC EDIDELYALL AIENVAEFYY DAVFSYFIET 200
    TDLSLEDGDA TILILKTYKD PDIALSLNDF LTMYSSTSST KTAETNTLIS 250
    KQSPSKRKQE KTSLNSNSLE KKRKQGSSLK YYNNEVDLVP SFYELRPQFN 300
    NILFELSNFP IVKENVNWTL YIQKFATKST QPFTKPFIWN RVFHLFSQVV 350
    DALIMIKNDH WDETQQQKQF FTHFLPFKEF SEEFENAIEA CRENNLDLIL 400
    LYKNYLSKTT AFKNLERILL TKFSAIVSPV HEKHYTLVNT WLTNLIQKLV 450
    KHPEDTNAFI NDYVLKNPLN HFICLNKKEK QSIALLLNKK RMSMLKDVEI 500
    EKNGFVQLQA FIENIGEAPA NYLDPENARK VNVEEVSEKD IPTLSTDKVS 550
    IPNESMFTSN KKHSIEKLIH AKLKAILSTM GQRLTRIIQE NYNNIAAGFL 600
    PVNDLNNLFA YLVKLYFDVY SITINGFVVE NELIKNIEQI YDNTQYLRFG 650
    LTRFNMQNLT PFTISVRKMF LDFFLSQKTL IDRAEEIIEN LEFKSVTPEG 700
    KQKLATKNML REQLEQLNAM DVDDTINLKT DTLTHQVLFS DQELRMIQDF 750
    ILQLSIHNIP SINFVKSLKL HIILEKRPDI LLALQEKVQN ILYFYFQDLV 800
    NEIPAQENVL STMLFIIELF PADSRIHLLE TGYISRHIVK KWLNMKSLQD 850
    AEDLIRFINI NKEQLGKFEH QPFGKEIQKL IEKIHLFYKQ KVIEYQEDVW 900
    SEMAKNIILT SPSELSQFLA SAPTQRIIQK HKNNLDQKLL IHMENQAKQA 950
    MEDDKKRVAC SKINLERHLN DLLLLLKDRQ FASIQASVLI VCENIFKTIP 1000
    DDNLIIQFSH ALLSVLLDIE KDLKSYSSEI LEKILINRPL ETSRLLVFKD 1050
    AYGNLKEFLN ALKQSLFATA DVQNKADFLI QILDFTYKFR HKTNKGKLLH 1100
    SIYNEDFKLY EETLTELRKK ATDAKESLTK LFKASEQKIE LSRTIPLKEI 1150
    YLNIETVNFQ GYGNVVFRES AFKRAIEVEI KNYEMKLNDL IKHFNSHLKT 1200
    KIDHIQILNL SFDNKWKDFV SKSKISFPPE LTISSQELIK DPIKVITETL 1250
    NKASNDLAYV ISEKILKWLI VFVKELNTFF VATMSEFGEV IPFDYKHFRA 1300
    LEYEINSKYI EIENKIICNE IIENTDNIEK LSTLIKQIDP NRIAGGKQKF 1350
    QDYLSKILTA ETNQQQTRYK EQLKKQYFDL LDNIAHFRFA FDFNHQQNLI 1400
    LKLKDKFKTL RTDTVFERFP NLDDTFVSSM NVENFLQALE ALSHFVQAAQ 1450
    NFLQNVLTEQ ADLFPQTNFI PVELSTVKTI PKSDINLRMK IHTPQTFFQV 1500
    DSVFNTQLIV DEKGIPVQFY NVFHNIVFKF FALNYKKIIV PDKVLNLVST 1550
    KYKILTTLKS ILSVVKSFWK EIINFDLTSY FQGKAEFTFQ NVFPIINLKI 1600
    FIYIITQAWS VTSDETQHSF ELPLEKFSLL IIANNPEFLF GSLQCPVDLA 1650
    INSLIPLLEK KKYFTAFTIS DNPPKLSMDE LKIVCLDLNT WSEITLEKYT 1700
    FKKNSLMQLC MGKEKFFIYL LSALVLPQNF LNYIWIQYKP SCCAQDSFQQ 1750
    LIQDLCFEYT HQNHIKPISL NLQEPNALKH GERILSKFVL EKNANTSLFS 1800
    IFLGKQFLLD YLLFSYLTAT EMTFSYYVDS IKNFLLTIRH LENVQQNVDF 1850
    RTILQSRNFD LKYLLTQSWT QNVLEQSIFH VQLDKIIADI KQPQLSLKKI 1900
    PLVLFNGDNE VVSTYVPPEQ ASQTEQSFRI KNIFPNPVQE YSSKNVILFT 1950
    NYPKNTKFLF NSPPPKTAAK SYKLPDTTDD INTETLSSPT IQRIPIKGLV 2000
    PKENEIVFLP EKNTAHTDSK ETKTHLIDTF NILSQTKGEI KTFSTDFDQT 2050
    ISKLKHLYF 2059
    Length:2,059
    Mass (Da):239,477
    Last modified:October 1, 1996 - v1
    Checksum:iAAE6CA6DEDC5D316
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43400 Genomic DNA. Translation: AAC54693.1.
    PIRiT41933.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43400 Genomic DNA. Translation: AAC54693.1 .
    PIRi T41933.

    3D structure databases

    ProteinModelPortali P52362.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P52362.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR006928. Pept_C76_UL36-USP.
    [Graphical view ]
    Pfami PF04843. Herpes_teg_N. 1 hit.
    [Graphical view ]
    PROSITEi PS51521. HTUSP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Determination and analysis of the complete nucleotide sequence of human herpesvirus."
      Nicholas J.
      J. Virol. 70:5975-5989(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiDEN_HHV7J
    AccessioniPrimary (citable) accession number: P52362
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3