SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P52362

- DEN_HHV7J

UniProt

P52362 - DEN_HHV7J

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Deneddylase

Gene
U31
Organism
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Deneddylase that deregulates the host cell cycle S phase to create a favorable environment allowing efficient viral genome replication. Interacts with and deneddylates host cullins including CUL1 and CUL4A, thereby reducing their E3 ubiquitin ligase activity. Inhibition of cullins leads to the stabilization of cullin-RING ligase substrates such as host CDN1A/p21, CDKN1B/p27kip and CDC25A, preventing S phase progression. Additionally, acts as a deubiquitinase and cleaves both 'Lys-48' and 'Lys-63'-linked ubiquitin chains By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei10 – 101Important for catalytic activity By similarity
Active sitei23 – 231 By similarity
Active sitei155 – 1551 By similarity
Active sitei157 – 1571 By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. modulation by virus of host protein ubiquitination Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Host-virus interaction, Modulation of host ubiquitin pathway by viral deubiquitinase, Modulation of host ubiquitin pathway by virus, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Deneddylase (EC:3.4.19.12, EC:3.4.22.-)
Alternative name(s):
Ubiquitin thioesterase
Gene namesi
Name:U31
OrganismiHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)
Taxonomic identifieri57278 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeRoseolovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000009246: Genome

Subcellular locationi

GO - Cellular componenti

  1. host cell cytoplasm Source: UniProtKB-SubCell
  2. host cell nucleus Source: UniProtKB-SubCell
  3. viral tegument Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Host nucleus, Virion, Virion tegument

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 20592059DeneddylasePRO_0000116042Add
BLAST

Proteomic databases

PRIDEiP52362.

Interactioni

Subunit structurei

Interacts with host CUL1 and CUL4A; these interactions inhibit the E3 ligase activity of cullins By similarity.

Structurei

3D structure databases

ProteinModelPortaliP52362.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 220218Peptidase C76Add
BLAST
Repeati273 – 29725LRR 1Add
BLAST
Repeati536 – 55924LRR 2Add
BLAST
Repeati714 – 74128LRR 3Add
BLAST
Repeati747 – 77024LRR 4Add
BLAST
Repeati852 – 87524LRR 5Add
BLAST
Repeati969 – 99123LRR 6Add
BLAST
Repeati1525 – 154723LRR 7Add
BLAST
Repeati1624 – 164017LRR 8Add
BLAST
Repeati1641 – 166525LRR 9Add
BLAST
Repeati1678 – 170124LRR 10Add
BLAST
Repeati1718 – 174124LRR 11Add
BLAST
Repeati1828 – 185225LRR 12Add
BLAST
Repeati1978 – 200225LRR 13Add
BLAST
Repeati2027 – 204923LRR 14Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1103 – 114038 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Family and domain databases

InterProiIPR006928. Pept_C76_UL36-USP.
[Graphical view]
PfamiPF04843. Herpes_teg_N. 1 hit.
[Graphical view]
PROSITEiPS51521. HTUSP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52362-1 [UniParc]FASTAAdd to Basket

« Hide

MRIIAGSTNQ NDPKYGPRAG KQCMSNCFSF LHTVYLNGIN NVLNKESIDI     50
IMENGALLDN ISTTTLKLET GNIPEYRFFT EIPKKISSNF GETIHELSRP 100
FNGTLESQHI DNEVYLGLLD FLLYGKNKKP AFIVITIGVM ARAIFIVDEL 150
FYLFDSHASD TENSAAIYIC EDIDELYALL AIENVAEFYY DAVFSYFIET 200
TDLSLEDGDA TILILKTYKD PDIALSLNDF LTMYSSTSST KTAETNTLIS 250
KQSPSKRKQE KTSLNSNSLE KKRKQGSSLK YYNNEVDLVP SFYELRPQFN 300
NILFELSNFP IVKENVNWTL YIQKFATKST QPFTKPFIWN RVFHLFSQVV 350
DALIMIKNDH WDETQQQKQF FTHFLPFKEF SEEFENAIEA CRENNLDLIL 400
LYKNYLSKTT AFKNLERILL TKFSAIVSPV HEKHYTLVNT WLTNLIQKLV 450
KHPEDTNAFI NDYVLKNPLN HFICLNKKEK QSIALLLNKK RMSMLKDVEI 500
EKNGFVQLQA FIENIGEAPA NYLDPENARK VNVEEVSEKD IPTLSTDKVS 550
IPNESMFTSN KKHSIEKLIH AKLKAILSTM GQRLTRIIQE NYNNIAAGFL 600
PVNDLNNLFA YLVKLYFDVY SITINGFVVE NELIKNIEQI YDNTQYLRFG 650
LTRFNMQNLT PFTISVRKMF LDFFLSQKTL IDRAEEIIEN LEFKSVTPEG 700
KQKLATKNML REQLEQLNAM DVDDTINLKT DTLTHQVLFS DQELRMIQDF 750
ILQLSIHNIP SINFVKSLKL HIILEKRPDI LLALQEKVQN ILYFYFQDLV 800
NEIPAQENVL STMLFIIELF PADSRIHLLE TGYISRHIVK KWLNMKSLQD 850
AEDLIRFINI NKEQLGKFEH QPFGKEIQKL IEKIHLFYKQ KVIEYQEDVW 900
SEMAKNIILT SPSELSQFLA SAPTQRIIQK HKNNLDQKLL IHMENQAKQA 950
MEDDKKRVAC SKINLERHLN DLLLLLKDRQ FASIQASVLI VCENIFKTIP 1000
DDNLIIQFSH ALLSVLLDIE KDLKSYSSEI LEKILINRPL ETSRLLVFKD 1050
AYGNLKEFLN ALKQSLFATA DVQNKADFLI QILDFTYKFR HKTNKGKLLH 1100
SIYNEDFKLY EETLTELRKK ATDAKESLTK LFKASEQKIE LSRTIPLKEI 1150
YLNIETVNFQ GYGNVVFRES AFKRAIEVEI KNYEMKLNDL IKHFNSHLKT 1200
KIDHIQILNL SFDNKWKDFV SKSKISFPPE LTISSQELIK DPIKVITETL 1250
NKASNDLAYV ISEKILKWLI VFVKELNTFF VATMSEFGEV IPFDYKHFRA 1300
LEYEINSKYI EIENKIICNE IIENTDNIEK LSTLIKQIDP NRIAGGKQKF 1350
QDYLSKILTA ETNQQQTRYK EQLKKQYFDL LDNIAHFRFA FDFNHQQNLI 1400
LKLKDKFKTL RTDTVFERFP NLDDTFVSSM NVENFLQALE ALSHFVQAAQ 1450
NFLQNVLTEQ ADLFPQTNFI PVELSTVKTI PKSDINLRMK IHTPQTFFQV 1500
DSVFNTQLIV DEKGIPVQFY NVFHNIVFKF FALNYKKIIV PDKVLNLVST 1550
KYKILTTLKS ILSVVKSFWK EIINFDLTSY FQGKAEFTFQ NVFPIINLKI 1600
FIYIITQAWS VTSDETQHSF ELPLEKFSLL IIANNPEFLF GSLQCPVDLA 1650
INSLIPLLEK KKYFTAFTIS DNPPKLSMDE LKIVCLDLNT WSEITLEKYT 1700
FKKNSLMQLC MGKEKFFIYL LSALVLPQNF LNYIWIQYKP SCCAQDSFQQ 1750
LIQDLCFEYT HQNHIKPISL NLQEPNALKH GERILSKFVL EKNANTSLFS 1800
IFLGKQFLLD YLLFSYLTAT EMTFSYYVDS IKNFLLTIRH LENVQQNVDF 1850
RTILQSRNFD LKYLLTQSWT QNVLEQSIFH VQLDKIIADI KQPQLSLKKI 1900
PLVLFNGDNE VVSTYVPPEQ ASQTEQSFRI KNIFPNPVQE YSSKNVILFT 1950
NYPKNTKFLF NSPPPKTAAK SYKLPDTTDD INTETLSSPT IQRIPIKGLV 2000
PKENEIVFLP EKNTAHTDSK ETKTHLIDTF NILSQTKGEI KTFSTDFDQT 2050
ISKLKHLYF 2059
Length:2,059
Mass (Da):239,477
Last modified:October 1, 1996 - v1
Checksum:iAAE6CA6DEDC5D316
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U43400 Genomic DNA. Translation: AAC54693.1.
PIRiT41933.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U43400 Genomic DNA. Translation: AAC54693.1 .
PIRi T41933.

3D structure databases

ProteinModelPortali P52362.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P52362.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR006928. Pept_C76_UL36-USP.
[Graphical view ]
Pfami PF04843. Herpes_teg_N. 1 hit.
[Graphical view ]
PROSITEi PS51521. HTUSP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Determination and analysis of the complete nucleotide sequence of human herpesvirus."
    Nicholas J.
    J. Virol. 70:5975-5989(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDEN_HHV7J
AccessioniPrimary (citable) accession number: P52362
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi