P52346 (AN_HHV7J) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alkaline nuclease
EC=3.1.-.-

Gene names

Name:

U70

Organism

Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) [Complete proteome]

Taxonomic identifier

57278 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Betaherpesvirinae › Roseolovirus › Human herpesvirus 7

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	480 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the baculo-herpesviridae alkaline nuclease family.

Ontologies

Keywords
Molecular function	Endonuclease Exonuclease Hydrolase Nuclease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	nucleic acid phosphodiester bond hydrolysis Inferred from electronic annotation. Source: GOC
Molecular_function	DNA binding Inferred from electronic annotation. Source: InterPro endonuclease activity Inferred from electronic annotation. Source: UniProtKB-KW exonuclease activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 480	480	Alkaline nuclease		PRO_0000115696

Sequences

	Sequence		Length	Mass (Da)
	P52346 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: CA3EAAF48B5113E2	FASTA	480	56,000
	10 20 30 40 50 60 MAIDYAQISC NLASIIEEDS VFLFLIDKLN NLDISRRKIS FNFIRLCYTY YILIKFNSRF 70 80 90 100 110 120 KDTFLARSFI DYMHQNISDF IDENVELSDL YSNIYVRLQD ASPKVVKNLF KILERETRGQ 130 140 150 160 170 180 STNPLWHAMR KNCITATKIY DIYISKSFSG IQEHSYLGDA VLYGIKHERI IEHLLKTFFV 190 200 210 220 230 240 KKPWISKTLG LLLDPSSGVF GASIDSYYGI SFNDNNLIEV GDKVVIFELK FRYKYLREKN 250 260 270 280 290 300 DLFVSELLQN PSEIALAKFI LSHPIPAIEY RENGKMPSAR EYLITNNPLY DSGKKRRACL 310 320 330 340 350 360 TPKNLTFDIT RLIPMNEKNV STAIIFDVVK DCILNTLVAY QKAIFTIDAF INPRHRYYFQ 370 380 390 400 410 420 SILQQYVMTQ FYIQDHDNPE NIEKENLPSV YIVSAIFRKR EDDEKNCRLL IEDTEYLEEE 430 440 450 460 470 480 IPLILLITPI TIDAEFTSRV IKDICCIWEN KIAQQTNLKI WAQSAVRQYM AASSARPKTP

References

[1]	"Determination and analysis of the complete nucleotide sequence of human herpesvirus." Nicholas J. J. Virol. 70:5975-5989(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	U43400 Genomic DNA. Translation: AAC54731.1.
PIR	T41971.
RefSeq	YP_073810.1. NC_001716.2.
3D structure databases
ProteinModelPortal	P52346.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3289528.
Phylogenomic databases
ProtClustDB	CLSP2510089.
Family and domain databases
Gene3D	3.90.320.10. 1 hit.
InterPro	IPR011604. Exonuc_phg/RecB_C. IPR001616. Herpes_alk_exo. IPR011335. Restrct_endonuc-II-like. [Graphical view]
Pfam	PF01771. Herpes_alk_exo. 1 hit. [Graphical view]
PRINTS	PR00924. ALKEXNUCLASE.
SUPFAM	SSF52980. Restrict_endonuc_II-like_core. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AN_HHV7J

Accession

Primary (citable) accession number: P52346

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	March 6, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program