Reviewed,
UniProtKB/Swiss-Prot P52343 (RIR1_HHV6U)
Last modified
February 9, 2010.
Version 52.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
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Names and origin
| Protein names | Recommended name: Ribonucleoside-diphosphate reductase large subunit-like protein U28 | ||||
| Gene names |
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| Organism | Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) [Complete proteome] | ||||
| Taxonomic identifier | 10370 [NCBI] | ||||
| Taxonomic lineage | Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Betaherpesvirinae › Roseolovirus | ||||
| Virus host | Homo sapiens (Human) [TaxID: 9606] |
Protein attributes
| Sequence length | 804 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Subunit structure | The genome of human herpesvirus-7 does not encode for a ribonucleotide reductase small subunit. |
| Sequence similarities | Belongs to the ribonucleoside diphosphate reductase large chain family. |
| Caution | Lacks the conserved sequence Asn-x-Cys-x-Glu essential for ribonucleotide reductase activity. Its enzyme activity is therefore uncertain. |
| Sequence caution | The sequence AAA16736.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. |
Ontologies
| Keywords | |
|---|---|
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | DNA replication Inferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | ribonucleoside-diphosphate reductase complex Inferred from electronic annotation. Source: InterPro |
| Molecular function | ribonucleoside-diphosphate reductase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 804 | 804 | Ribonucleoside-diphosphate reductase large subunit-like protein U28 | PRO_0000187238 | |||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Nucleotide sequence analysis of a 38.5-kilobase-pair region of the genome of human herpesvirus 6 encoding human cytomegalovirus immediate-early gene homologs and transactivating functions." Nicholas J., Martin M.E.D. J. Virol. 68:597-610(1994) [PubMed: 8289364] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution." Gompels U.A., Nicholas J., Lawrence G.L., Jones M., Thomson B.J., Martin M.E.D., Efstathiou S., Craxton M.A., Macaulay H.A. Virology 209:29-51(1995) [PubMed: 7747482] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | "The U28 ORF of human herpesvirus-7 does not encode a functional ribonucleotide reductase R1 subunit." Sun Y., Conner J. J. Gen. Virol. 80:2713-2718(1999) [PubMed: 10573165] [Abstract] Cited for: ABSENCE OF RIBONUCLEOTIDE REDUCTASE ACTIVITY, ABSENCE OF GENE FOR SMALL SUBUNIT. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | L25528 Genomic DNA. Translation: AAA16736.1. Different initiation. X83413 Genomic DNA. Translation: CAA58408.1. |
| PIR | T09323. |
| RefSeq | NP_042921.1. |
3D structure databases | |
| SMR | P52343. Positions 140-769. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1487905. |
Family and domain databases | |
| InterPro | IPR000788. Ribncl_red_lg_C. [Graphical view] |
| PANTHER | PTHR11573. Ribncl_red_lg_C. 1 hit. |
| Pfam | PF02867. Ribonuc_red_lgC. 1 hit. [Graphical view] |
| PRINTS | PR01183. RIBORDTASEM1. |
| PROSITE | PS00089. RIBORED_LARGE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | RIR1_HHV6U | ||||||||
| Accession | Primary (citable) accession number: P52343 Secondary accession number(s): Q89941 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Virus (Virus annotation project) | ||||||||

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