P52343 (RRL_HHV6U) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribonucleoside-diphosphate reductase large subunit-like protein U28

Gene names

Name:	U28
Synonyms:	P2LF2

Organism

Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus)

Taxonomic identifier

10370 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Betaherpesvirinae › Roseolovirus

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	804 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Does not have ribonucleotide reductase activity. Betaherpesviruses probably use another strategy to expand the dNTP pool in a quiescent host cell By similarity.
Sequence similarities	Belongs to the ribonucleoside diphosphate reductase large chain family.
Caution	Lacks the conserved sequence Asn-x-Cys-x-Glu essential for ribonucleotide reductase activity. Its enzyme activity is therefore uncertain.
Sequence caution	The sequence AAA16736.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	DNA replication Inferred from electronic annotation. Source: InterPro
Cellular component	ribonucleoside-diphosphate reductase complex Inferred from electronic annotation. Source: InterPro
Molecular function	ribonucleoside-diphosphate reductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 804	804	Ribonucleoside-diphosphate reductase large subunit-like protein U28		PRO_0000187238

Sequences

	Sequence		Length	Mass (Da)
	P52343 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: E01A17F36B571EAE	FASTA	804	93,353
	10 20 30 40 50 60 MKRKERRINK DYGYNRKCVC HYEASQKRFC YSQYSCASVL YERVRDIAKI IDRLDSGLDA 70 80 90 100 110 120 WCLRDAIISV LRATHCVPRV DRMLGRWYLK TSVFYDFCPD DLILSCPNVI MPNVLNFVKK 130 140 150 160 170 180 YRDFIRSVLY KVSVSWKNQY MPGVLAASRF LEEISNSLNG VEESIPCIYL RMCATLTEIV 190 200 210 220 230 240 LRIGYLREIY QENPYVMFEE LAFSLFTQKW VLPFSCMTNL GLVEKANSTV FDVAIYNTCL 250 260 270 280 290 300 YSLVDFTIVN GEHLFPALLN GSNISMNLTR YQQEAKNIFE ILLSQIRVVE RDTDKTVQLT 310 320 330 340 350 360 VYVEVWHVSA LMWLDLYEAL PQTSRVTFCL IIPGIFMDRY ELKRAQWSLF HKNIAFELGK 370 380 390 400 410 420 CDEITFSTKY LEFERTTDHA KITMSSFIEK ICLCLKGGRM GLIFRKNVYQ YSMIPHVPLY 430 440 450 460 470 480 CGGDFLDVLP VRDGINTCMR MLLNVVHFLG DEVSDELTEE IDFVRLQCKF FMFNELRRVV 490 500 510 520 530 540 RKMVLVANAV IDYAVENKDF LCEGIEDGRS LGICVTGLHS VFMTVGLSYA HPDARRLYRM 550 560 570 580 590 600 ICEHIYYTCV RTSVDCCMKG AEPCNLFDRS KYALGMLYFD HFDNVECTLP EELWTTLRKD 610 620 630 640 650 660 VLMHGVRNIH FTAGTAMQKE FDIINSSESF WPMEDNKILR RSNIKVVIGK DGLNDVTSVY 670 680 690 700 710 720 SSELKSLYIP VYNNLLLNRF NKHQQYLKTV GYRVLNVDTN LFTDKELDDL AVFKDGFSYH 730 740 750 760 770 780 LNDLIEMYKS GLPFLDQGQA NVFYFNDTVS LRLLLPLLYK AGFKVAMYKV LCNSEMYKHL 790 800 DLSNPLPLIG KCSDGVVMHV KNIL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence analysis of a 38.5-kilobase-pair region of the genome of human herpesvirus 6 encoding human cytomegalovirus immediate-early gene homologs and transactivating functions." Nicholas J., Martin M.E.D. J. Virol. 68:597-610(1994) [PubMed: 8289364] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution." Gompels U.A., Nicholas J., Lawrence G.L., Jones M., Thomson B.J., Martin M.E.D., Efstathiou S., Craxton M.A., Macaulay H.A. Virology 209:29-51(1995) [PubMed: 7747482] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The U28 ORF of human herpesvirus-7 does not encode a functional ribonucleotide reductase R1 subunit." Sun Y., Conner J. J. Gen. Virol. 80:2713-2718(1999) [PubMed: 10573165] [Abstract] Cited for: ABSENCE OF RIBONUCLEOTIDE REDUCTASE ACTIVITY, ABSENCE OF GENE FOR SMALL SUBUNIT.
[4]	"Tinkering with a viral ribonucleotide reductase." Lembo D., Brune W. Trends Biochem. Sci. 34:25-32(2009) [PubMed: 18990579] [Abstract] Cited for: REVIEW.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L25528 Genomic DNA. Translation: AAA16736.1. Different initiation. X83413 Genomic DNA. Translation: CAA58408.1.
PIR	T09323.
RefSeq	NP_042921.1. NC_001664.2.
3D structure databases
ProteinModelPortal	P52343.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1487905.
Phylogenomic databases
ProtClustDB	CLSP2510057.
Family and domain databases
InterPro	IPR000788. Ribncl_red_lg_C. [Graphical view]
Pfam	PF02867. Ribonuc_red_lgC. 1 hit. [Graphical view]
PRINTS	PR01183. RIBORDTASEM1.
PROSITE	PS00089. RIBORED_LARGE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RRL_HHV6U

Accession

Primary (citable) accession number: P52343
Secondary accession number(s): Q89941

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	September 21, 2011
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program