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P52341

- DUT_HHV7J

UniProt

P52341 - DUT_HHV7J

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Protein
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Gene
U45
Organism
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.

Cofactori

Magnesium By similarity.

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
Name:U45
OrganismiHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)
Taxonomic identifieri57278 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeRoseolovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000009246: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 379379Deoxyuridine 5'-triphosphate nucleotidohydrolase
PRO_0000182961Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP52341.

Family & Domainsi

Sequence similaritiesi

Belongs to the dUTPase family.

Family and domain databases

InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 2 hits.

Sequencei

Sequence statusi: Complete.

P52341-1 [UniParc]FASTAAdd to Basket

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MQSLPSRRSE TNKKIISEKI SETITLNKLP MSRYLHFFLF TVTDVDDIWN    50
FSETKESSLT WPKIDAKQLN EYVNTELTVY QRPFSLLGIP QNGLFKSCEK 100
IYDEFFAEHM DNEKKYLTFP RNRSSRFGFE NVPRVNELPI LINHFEKSRM 150
DVILNTNKIV LVNRELIWVP CEQVRIFNLN VSLNIPDGLF GILTGTVNDT 200
LCECVTELIT TENVISISLI NLSSESVMLL PGDIELVINI LPCYIPEPWE 250
TYNFPSPNFI KFSLITNKDF YVESNNYTIQ NFDYMFDCPD ELKALIIANK 300
EILCHGLVVE TNIWLKNTTP SVKIFNPTSQ RIFVQAGICI ATIIFTCGHF 350
ILKLLPNRVL NQLAVLDKTS MLWFQYSTE 379
Length:379
Mass (Da):43,877
Last modified:October 1, 1996 - v1
Checksum:i56C61E097B67AD7C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U43400 Genomic DNA. Translation: AAC54707.1.
PIRiT41947.
RefSeqiYP_073785.1. NC_001716.2.

Genome annotation databases

GeneIDi3289503.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U43400 Genomic DNA. Translation: AAC54707.1 .
PIRi T41947.
RefSeqi YP_073785.1. NC_001716.2.

3D structure databases

ProteinModelPortali P52341.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3289503.

Family and domain databases

InterProi IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view ]
Pfami PF00692. dUTPase. 1 hit.
[Graphical view ]
SUPFAMi SSF51283. SSF51283. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Determination and analysis of the complete nucleotide sequence of human herpesvirus."
    Nicholas J.
    J. Virol. 70:5975-5989(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDUT_HHV7J
AccessioniPrimary (citable) accession number: P52341
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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