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P52341

- DUT_HHV7J

UniProt

P52341 - DUT_HHV7J

Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

U45

Organism
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

    Catalytic activityi

    dUTP + H2O = dUMP + diphosphate.

    Cofactori

    Magnesium.By similarity

    GO - Molecular functioni

    1. dUTP diphosphatase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. dUTP metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    Magnesium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
    Short name:
    dUTPase
    Alternative name(s):
    dUTP pyrophosphatase
    Gene namesi
    Name:U45
    OrganismiHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)
    Taxonomic identifieri57278 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeRoseolovirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000009246: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 379379Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000182961Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP52341.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the dUTPase family.Curated

    Family and domain databases

    InterProiIPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    [Graphical view]
    PfamiPF00692. dUTPase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51283. SSF51283. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    P52341-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQSLPSRRSE TNKKIISEKI SETITLNKLP MSRYLHFFLF TVTDVDDIWN    50
    FSETKESSLT WPKIDAKQLN EYVNTELTVY QRPFSLLGIP QNGLFKSCEK 100
    IYDEFFAEHM DNEKKYLTFP RNRSSRFGFE NVPRVNELPI LINHFEKSRM 150
    DVILNTNKIV LVNRELIWVP CEQVRIFNLN VSLNIPDGLF GILTGTVNDT 200
    LCECVTELIT TENVISISLI NLSSESVMLL PGDIELVINI LPCYIPEPWE 250
    TYNFPSPNFI KFSLITNKDF YVESNNYTIQ NFDYMFDCPD ELKALIIANK 300
    EILCHGLVVE TNIWLKNTTP SVKIFNPTSQ RIFVQAGICI ATIIFTCGHF 350
    ILKLLPNRVL NQLAVLDKTS MLWFQYSTE 379
    Length:379
    Mass (Da):43,877
    Last modified:October 1, 1996 - v1
    Checksum:i56C61E097B67AD7C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43400 Genomic DNA. Translation: AAC54707.1.
    PIRiT41947.
    RefSeqiYP_073785.1. NC_001716.2.

    Genome annotation databases

    GeneIDi3289503.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43400 Genomic DNA. Translation: AAC54707.1 .
    PIRi T41947.
    RefSeqi YP_073785.1. NC_001716.2.

    3D structure databases

    ProteinModelPortali P52341.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3289503.

    Family and domain databases

    InterProi IPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    [Graphical view ]
    Pfami PF00692. dUTPase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51283. SSF51283. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Determination and analysis of the complete nucleotide sequence of human herpesvirus."
      Nicholas J.
      J. Virol. 70:5975-5989(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiDUT_HHV7J
    AccessioniPrimary (citable) accession number: P52341
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3