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P52341 (DUT_HHV7J) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase

Short name=dUTPase
EC=3.6.1.23
Alternative name(s):
dUTP pyrophosphatase
Gene names
Name:U45
OrganismHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) [Complete proteome]
Taxonomic identifier57278 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeRoseolovirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length379 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Catalytic activity

dUTP + H2O = dUMP + diphosphate.

Cofactor

Magnesium By similarity.

Sequence similarities

Belongs to the dUTPase family.

Ontologies

Keywords
   Biological processNucleotide metabolism
   LigandMagnesium
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processdUTP metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functiondUTP diphosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 379379Deoxyuridine 5'-triphosphate nucleotidohydrolase
PRO_0000182961

Sequences

Sequence LengthMass (Da)Tools
P52341 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 56C61E097B67AD7C

FASTA37943,877
        10         20         30         40         50         60 
MQSLPSRRSE TNKKIISEKI SETITLNKLP MSRYLHFFLF TVTDVDDIWN FSETKESSLT 

        70         80         90        100        110        120 
WPKIDAKQLN EYVNTELTVY QRPFSLLGIP QNGLFKSCEK IYDEFFAEHM DNEKKYLTFP 

       130        140        150        160        170        180 
RNRSSRFGFE NVPRVNELPI LINHFEKSRM DVILNTNKIV LVNRELIWVP CEQVRIFNLN 

       190        200        210        220        230        240 
VSLNIPDGLF GILTGTVNDT LCECVTELIT TENVISISLI NLSSESVMLL PGDIELVINI 

       250        260        270        280        290        300 
LPCYIPEPWE TYNFPSPNFI KFSLITNKDF YVESNNYTIQ NFDYMFDCPD ELKALIIANK 

       310        320        330        340        350        360 
EILCHGLVVE TNIWLKNTTP SVKIFNPTSQ RIFVQAGICI ATIIFTCGHF ILKLLPNRVL 

       370 
NQLAVLDKTS MLWFQYSTE 

« Hide

References

[1]"Determination and analysis of the complete nucleotide sequence of human herpesvirus."
Nicholas J.
J. Virol. 70:5975-5989(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U43400 Genomic DNA. Translation: AAC54707.1.
PIRT41947.
RefSeqYP_073785.1. NC_001716.2.

3D structure databases

ProteinModelPortalP52341.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3289503.

Phylogenomic databases

ProtClustDBPHA3125.

Family and domain databases

InterProIPR008180. dUTP_pyroPase.
[Graphical view]
PfamPF00692. dUTPase. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDUT_HHV7J
AccessionPrimary (citable) accession number: P52341
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 16, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families