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Reviewed, UniProtKB/Swiss-Prot P52333 (JAK3_HUMAN)

Last modified June 16, 2009. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Tyrosine-protein kinase JAK3
    EC=2.7.10.2
Alternative name(s):
    Janus kinase 3
      Short name=JAK-3
    Leukocyte janus kinase
      Short name=L-JAK
Gene names
Name: JAK3
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1124 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Tyrosine kinase of the non-receptor type, involved in the interleukin-2 and interleukin-4 signaling pathway. Phosphorylates STAT6, IRS1, IRS2 and PI3K.

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subunit structure

Interacts with STAM2 and MYO18A By similarity. Interacts with SHB.

Subcellular location

Endomembrane system; Peripheral membrane protein By similarity. Note: Wholly intracellular, possibly membrane associated By similarity.

Tissue specificity

In NK cells and an NK-like cell line but not in resting T-cells or in other tissues. The S-form is more commonly seen in hematopoietic lines, whereas the B- and M-forms are detected in cells both of hematopoietic and epithelial origins.

Domain

Possesses two phosphotransferase domains. The second one probably contains the catalytic domain By similarity, while the presence of slight differences suggest a different role for domain 1.

Post-translational modification

Tyrosine phosphorylated in response to IL-2 and IL-4. Ref.8

Involvement in disease

Defects in JAK3 are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-negative (T-B+NK-SCID) [MIM:600802]. SCID refers to a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients with SCID present in infancy with recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development. Ref.8 Ref.3 Ref.9 Ref.10 Ref.11 Ref.12 Ref.13 Ref.14

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.

Contains 1 FERM domain.

Contains 1 protein kinase domain.

Contains 1 SH2 domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

KHDRBS1Q076661EBI-518246,EBI-1364

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 2 (identifier: P52333-1)

Also known as: JAK3S; Spleen-JAK3;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 1 (identifier: P52333-2)

Also known as: JAK3B; Breast-JAK3;

The sequence of this isoform differs from the canonical sequence as follows:
     1071-1124: HELMKLCWAP...EGKHHSLSFS → SAAGLASVSQSVDWAGVSGKPAGA
Note: May be inactive as it lacks some part of the kinase domain.
Isoform 3 (identifier: P52333-3)

Also known as: JAK3M; Activated monocytes-JAK3;

The sequence of this isoform differs from the canonical sequence as follows:
     1071-1124: HELMKLCWAP...EGKHHSLSFS → SCYSGWRDDI...ASVAVPNKTC

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11241124Tyrosine-protein kinase JAK3
PRO_0000088115

Regions

Domain24 – 356333FERM
Domain375 – 475101SH2; atypical
Domain521 – 781261Protein kinase 1
Domain822 – 1111290Protein kinase 2
Nucleotide binding828 – 8369ATP By similarity

Sites

Active site9491Proton acceptor By similarity
Binding site8551ATP By similarity

Amino acid modifications

Modified residue81Phosphothreonine By similarity
Modified residue7851Phosphotyrosine Ref.8
Modified residue9801Phosphotyrosine; by autocatalysis By similarity
Modified residue10271Phosphoserine By similarity
Modified residue10311Phosphoserine By similarity

Natural variations

Alternative sequence1071 – 112454HELMK…SLSFS → SAAGLASVSQSVDWAGVSGK PAGA in isoform 1.
VSP_004989
Alternative sequence1071 – 112454HELMK…SLSFS → SCYSGWRDDICSMGWWPTVI SRWDLACSPCPRPLTITATT VQLPPTLHATAASVAVPNKT C in isoform 3.
VSP_004990
Natural variant121P → L Ref.14
VAR_041722
Natural variant401R → H Ref.14
VAR_041723
Natural variant581Missing in T(-)B(+)NK(-)SCID. Ref.13
VAR_019337
Natural variant1001Y → C in T(-)B(+)NK(-)SCID. Ref.9
VAR_006284
Natural variant1321P → T: dbSNP rs3212723. Ref.3 Ref.14
VAR_019336
Natural variant1511P → R in T(-)B(+)NK(-)SCID. Ref.12
VAR_010492
Natural variant1691D → E in T(-)B(+)NK(-)SCID. Ref.13
VAR_019338
Natural variant4811E → G in T(-)B(+)NK(-)SCID. Ref.10
VAR_010493
Natural variant5211L → V Ref.14
VAR_041724
Natural variant5271L → P in a gastric adenocarcinoma sample; somatic mutation. Ref.14
VAR_041725
Natural variant5821R → W in T(-)B(+)NK(-)SCID. Ref.11
VAR_010494
Natural variant586 – 5927Missing in T(-)B(+)NK(-)SCID; lack of phosphorylation in response to cytokine stimulation. Ref.10
VAR_010495
Natural variant5891G → S in T(-)B(+)NK(-)SCID. Ref.13
VAR_019339
Natural variant6881I → F: dbSNP rs35785705. Ref.14
VAR_041726
Natural variant7221V → I: dbSNP rs3213409. Ref.3 Ref.12 Ref.13 Ref.14
VAR_010496
Natural variant7591C → R in T(-)B(+)NK(-)SCID; constitutive phosphorylation. Ref.10
VAR_010497
Natural variant9101L → S in T(-)B(+)NK(-)SCID. Ref.12
VAR_010498

Experimental info

Sequence conflict341G → A in AAA19626. Ref.1
Sequence conflict1471Missing in AAC50542. Ref.5
Sequence conflict1871T → A in AAC50542. Ref.5
Sequence conflict2121R → A in AAA19626. Ref.1
Sequence conflict2221R → P in AAA19626. Ref.1
Sequence conflict6101M → I in AAC50226. Ref.2
Sequence conflict845 – 8462GD → AH in AAA19626. Ref.1
Sequence conflict896 – 8972QS → PE in AAA19626. Ref.1

Secondary structure

.................................................. 1124
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 2 (JAK3S) (Spleen-JAK3) [UniParc].

Last modified July 19, 2004. Version 2.
Checksum: 895D8563439B2B7C

FASTA1,124125,099
        10         20         30         40         50         60 
MAPPSEETPL IPQRSCSLLS TEAGALHVLL PARGPGPPQR LSFSFGDHLA EDLCVQAAKA 

        70         80         90        100        110        120 
SGILPVYHSL FALATEDLSC WFPPSHIFSV EDASTQVLLY RIRFYFPNWF GLEKCHRFGL 

       130        140        150        160        170        180 
RKDLASAILD LPVLEHLFAQ HRSDLVSGRL PVGLSLKEQG ECLSLAVLDL ARMAREQAQR 

       190        200        210        220        230        240 
PGELLKTVSY KACLPPSLRD LIQGLSFVTR RRIRRTVRRA LRRVAACQAD RHSLMAKYIM 

       250        260        270        280        290        300 
DLERLDPAGA AETFHVGLPG ALGGHDGLGL LRVAGDGGIA WTQGEQEVLQ PFCDFPEIVD 

       310        320        330        340        350        360 
ISIKQAPRVG PAGEHRLVTV TRTDNQILEA EFPGLPEALS FVALVDGYFR LTTDSQHFFC 

       370        380        390        400        410        420 
KEVAPPRLLE EVAEQCHGPI TLDFAINKLK TGGSRPGSYV LRRSPQDFDS FLLTVCVQNP 

       430        440        450        460        470        480 
LGPDYKGCLI RRSPTGTFLL VGLSRPHSSL RELLATCWDG GLHVDGVAVT LTSCCIPRPK 

       490        500        510        520        530        540 
EKSNLIVVQR GHSPPTSSLV QPQSQYQLSQ MTFHKIPADS LEWHENLGHG SFTKIYRGCR 

       550        560        570        580        590        600 
HEVVDGEARK TEVLLKVMDA KHKNCMESFL EAASLMSQVS YRHLVLLHGV CMAGDSTMVQ 

       610        620        630        640        650        660 
EFVHLGAIDM YLRKRGHLVP ASWKLQVVKQ LAYALNYLED KGLPHGNVSA RKVLLAREGA 

       670        680        690        700        710        720 
DGSPPFIKLS DPGVSPAVLS LEMLTDRIPW VAPECLREAQ TLSLEADKWG FGATVWEVFS 

       730        740        750        760        770        780 
GVTMPISALD PAKKLQFYED RQQLPAPKWT ELALLIQQCM AYEPVQRPSF RAVIRDLNSL 

       790        800        810        820        830        840 
ISSDYELLSD PTPGALAPRD GLWNGAQLYA CQDPTIFEER HLKYISQLGK GNFGSVELCR 

       850        860        870        880        890        900 
YDPLGDNTGA LVAVKQLQHS GPDQQRDFQR EIQILKALHS DFIVKYRGVS YGPGRQSLRL 

       910        920        930        940        950        960 
VMEYLPSGCL RDFLQRHRAR LDASRLLLYS SQICKGMEYL GSRRCVHRDL AARNILVESE 

       970        980        990       1000       1010       1020 
AHVKIADFGL AKLLPLDKDY YVVREPGQSP IFWYAPESLS DNIFSRQSDV WSFGVVLYEL 

      1030       1040       1050       1060       1070       1080 
FTYCDKSCSP SAEFLRMMGC ERDVPALCRL LELLEEGQRL PAPPACPAEV HELMKLCWAP 

      1090       1100       1110       1120 
SPQDRPSFSA LGPQLDMLWS GSRGCETHAF TAHPEGKHHS LSFS 

« Hide

Isoform 1 (JAK3B) (Breast-JAK3).

Checksum: D491FADB3D772693
Show »

FASTA1,094121,268
Isoform 3 (JAK3M) (Activated monocytes-JAK3).

Checksum: B6CFA497BD549C19
Show »

FASTA1,131125,729

References

« Hide 'large scale' references
[1]"Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes."
Kawamura M., McVicar D.W., Johnston J.A., Blake T.B., Chen Y.-Q., Lal B.K., Lloyd A.R., Kelvin D.J., Staples J.E., Ortaldo J.R., O'Shea J.J.
Proc. Natl. Acad. Sci. U.S.A. 91:6374-6378(1994) [PubMed: 8022790] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]"A kinase-deficient splice variant of the human JAK3 is expressed in hematopoietic and epithelial cancer cells."
Lai K.S., Jin Y., Graham D.K., Witthuhn B.A., Ihle J.N., Liu E.T.
J. Biol. Chem. 270:25028-25036(1995) [PubMed: 7559633] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3).
[3]SeattleSNPs variation discovery resource
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-132 AND ILE-722.
[4]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed: 15057824] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"Expression of Janus kinase 3 in human endothelial and other non-lymphoid and non-myeloid cells."
Verbsky J.W., Bach E.A., Fang Y.F., Yang L., Randolph D.A., Fields L.E.
J. Biol. Chem. 271:13976-13980(1996) [PubMed: 8662778] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 36-191.
[6]"STAM2, a new member of the STAM family, binding to the Janus kinases."
Endo K., Takeshita T., Kasai H., Sasaki Y., Tanaka N., Asao H., Kikuchi K., Yamada M., Chenb M., O'Shea J.J., Sugamura K.
FEBS Lett. 477:55-61(2000) [PubMed: 10899310] [Abstract]
Cited for: INTERACTION WITH STAM2.
Tissue: Fetal brain.
[7]"IL-2 receptor signaling through the Shb adapter protein in T and NK cells."
Lindholm C.K.
Biochem. Biophys. Res. Commun. 296:929-936(2002) [PubMed: 12200137] [Abstract]
Cited for: INTERACTION WITH SHB.
[8]"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
Nat. Biotechnol. 23:94-101(2005) [PubMed: 15592455] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-785, MASS SPECTROMETRY.
[9]"Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)."
Macchi P., Villa A., Giliani S., Sacco M.G., Frattini A., Porta F., Ugazio A.G., Johnston J.A., Candotti F., O'Shea J.J., Vezzoni P., Notarangelo L.D.
Nature 377:65-68(1995) [PubMed: 7659163] [Abstract]
Cited for: VARIANT T(-)B(+)NK(-)SCID CYS-100.
[10]"Structural and functional basis for JAK3-deficient severe combined immunodeficiency."
Candotti F., Oakes S.A., Johnston J.A., Giliani S., Schumacher R.F., Mella P., Fiorini M., Ugazio A.G., Badolato R., Notarangelo L.D., Bozzi F., Macchi P., Strina D., Vezzoni P., Blaese R.M., O'Shea J.J., Villa A.
Blood 90:3996-4003(1997) [PubMed: 9354668] [Abstract]
Cited for: VARIANTS T(-)B(+)NK(-)SCID GLY-481; 586-LEU--MET-592 DEL AND ARG-759.
[11]"Molecular and biochemical characterization of JAK3 deficiency in a patient with severe combined immunodeficiency over 20 years after bone marrow transplantation: implications for treatment."
Bozzi F., Lefranc G., Villa A., Badolato R., Schumacher R.F., Khalil G., Loiselet J., Bresciani S., O'Shea J.J., Vezzoni P., Notarangelo L.D., Candotti F.
Br. J. Haematol. 102:1363-1366(1998) [PubMed: 9753072] [Abstract]
Cited for: VARIANT T(-)B(+)NK(-)SCID TRP-582.
[12]"Complete genomic organization of the human JAK3 gene and mutation analysis in severe combined immunodeficiency by single-strand conformation polymorphism."
Schumacher R.F., Mella P., Badolato R., Fiorini M., Savoldi G., Giliani S., Villa A., Candotti F., Tampalini A., O'Shea J.J., Notarangelo L.D.
Hum. Genet. 106:73-79(2000) [PubMed: 10982185] [Abstract]
Cited for: VARIANTS T(-)B(+)NK(-)SCID ARG-151 AND SER-910, VARIANT ILE-722.
[13]"Janus kinase 3 (JAK3) deficiency: clinical, immunologic, and molecular analyses of 10 patients and outcomes of stem cell transplantation."
Roberts J.L., Lengi A., Brown S.M., Chen M., Zhou Y.-J., O'Shea J.J., Buckley R.H.
Blood 103:2009-2018(2004) [PubMed: 14615376] [Abstract]
Cited for: VARIANTS T(-)B(+)NK(-)SCID ALA-58 DEL; GLU-169 AND SER-589, VARIANT ILE-722.
[14]"Patterns of somatic mutation in human cancer genomes."
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. expand/collapse author list , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
Nature 446:153-158(2007) [PubMed: 17344846] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-12; HIS-40; THR-132; ARG-151; VAL-521; PRO-527; PHE-688 AND ILE-722.
+Additional computationally mapped references.

Cross-references

Sequence databases

U09607 mRNA. Translation: AAA19626.1.
U31601 mRNA. Translation: AAC50226.1.
U31602 mRNA. Translation: AAC50227.1.
AF513860 Genomic DNA. Translation: AAM44860.1.
AC007201 Genomic DNA. Translation: AAD22741.1.
U57096 mRNA. Translation: AAC50542.1.
IPIIPI00002773.
IPI00219417.
IPI00219418.
PIRA55747.
RefSeqNP_000206.2.
UniGeneHs.515247

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1YVJX-ray2.55A814-1103[»]
ModBaseSearch...

Protein-protein interaction databases

DIPDIP:274N.
IntActP52333. 3 interactions.

PTM databases

PhosphoSiteP52333.

Proteomic databases

PRIDEP52333.

Genome annotation databases

EnsemblENSG00000105639. Homo sapiens. [Contig view]
GeneID3718.
KEGGhsa:3718.

Organism-specific databases

GeneCardsGC19M017790.
HGNCHGNC:6193. JAK3.
MIM600173. gene.
600802. phenotype.
Orphanet35078. Severe combined immunodeficiency T- B+ due to JAK3 deficiency.
PharmGKBPA29990.
GenAtlasSearch...

Phylogenomic databases

HOVERGENP52333.
OMAP52333. NCMESFL.

Enzyme and pathway databases

BRENDA2.7.10.2. 247.
Pathway_Interaction_DBil2_pi3kpathway. IL2 signaling events mediated by PI3K.
il2_stat5pathway. IL2 signaling events mediated by STAT5.
il2_1pathway. IL2-mediated signaling events.
il4_2pathway. IL4-mediated signaling events.

Gene expression databases

ArrayExpressP52333.
BgeeP52333.
CleanExHS_JAK3.
GermOnlineENSG00000105639. Homo sapiens.

Family and domain databases

InterProIPR019749. Band_41_domain.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR009127. JAK.
IPR009130. JAK3.
IPR000719. Prot_kinase_core.
IPR017441. Protein_kinase_ATP_BS.
IPR000980. SH2.
IPR001245. Tyr_pkinase.
IPR008266. Tyr_pkinase_AS.
IPR016251. TyrPK_Jak.
[Graphical view]
PfamPF07714. Pkinase_Tyr. 2 hits.
[Graphical view]
PIRSFPIRSF000636. TyrPK_Jak. 1 hit.
PRINTSPR01823. JANUSKINASE.
PR01826. JANUSKINASE3.
PR00109. TYRKINASE.
ProDomPD000001. Prot_kinase. 2 hits.
PD000093. SH2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00295. B41. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 2 hits.
[Graphical view]
PROSITEPS00660. FERM_1. False negative.
PS00661. FERM_2. False negative.
PS50057. FERM_3. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. False negative.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio14571.
SOURCESearch...

Entry information

Entry nameJAK3_HUMAN
AccessionPrimary (citable) accession number: P52333
Secondary accession number(s): Q13259 expand/collapse secondary AC list , Q13260, Q13611, Q9Y6S2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 19, 2004
Last modified: June 16, 2009
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents