Reviewed,
UniProtKB/Swiss-Prot P52332 (JAK1_MOUSE)
Last modified
October 13, 2009.
Version 91.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Tyrosine-protein kinase JAK1 EC=2.7.10.2 Alternative name(s): Janus kinase 1 Short name=JAK-1 | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 1153 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor. |
| Catalytic activity | ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. |
| Subunit structure | Interacts with IL31RA, JAKMIP1 and SHB By similarity. |
| Subcellular location | Endomembrane system; Peripheral membrane protein. Note: Wholly intracellular, possibly membrane associated. |
| Domain | The FERM domain mediates interaction with JAKMIP1 By similarity. Possesses two phosphotransferase domains. The second one probably contains the catalytic domain By similarity, while the presence of slight differences suggest a different role for domain 1. |
| Sequence similarities | Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. Contains 1 FERM domain. Contains 1 protein kinase domain. Contains 1 SH2 domain. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1153 | 1153 | Tyrosine-protein kinase JAK1 | PRO_0000088109 | |||||
Regions | |||||||||
| Domain | 34 – 420 | 387 | FERM | ||||||
| Domain | 439 – 542 | 104 | SH2 | ||||||
| Domain | 582 – 854 | 273 | Protein kinase 1 | ||||||
| Domain | 874 – 1152 | 279 | Protein kinase 2 | ||||||
| Nucleotide binding | 880 – 888 | 9 | ATP By similarity | ||||||
Sites | |||||||||
| Active site | 1002 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 907 | 1 | ATP By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 1033 | 1 | Phosphotyrosine; by autocatalysis By similarity | ||||||
| Modified residue | 1034 | 1 | Phosphotyrosine By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 999 | 1 | V → I Ref.3 | ||||||
| Sequence conflict | 999 | 1 | V → I Ref.4 | ||||||
| Sequence conflict | 1068 – 1069 | 2 | VT → IP Ref.3 | ||||||
| Sequence conflict | 1068 – 1069 | 2 | VT → IP Ref.4 | ||||||
Sequences
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References
| [1] | "Molecular cloning of the murine JAK1 protein tyrosine kinase and its expression in the mouse central nervous system." Yang X., Chung D., Cepko C.L. J. Neurosci. 13:3006-3017(1993) [PubMed: 8331382] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | Lubec G., Sunyer B., Chen W.-Q. Submitted (JAN-2009) to UniProtKB Cited for: PROTEIN SEQUENCE OF 718-723, MASS SPECTROMETRY. Strain: OF1. Tissue: Hippocampus. |
| [3] | "The application of the polymerase chain reaction to cloning members of the protein tyrosine kinase family." Wilks A.F., Kurban R.R., Hovens C.M., Ralph S.J. Gene 85:67-74(1989) [PubMed: 2482828] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 999-1069. |
| [4] | "Two putative protein-tyrosine kinases identified by application of the polymerase chain reaction." Wilks A.F. Proc. Natl. Acad. Sci. U.S.A. 86:1603-1607(1989) [PubMed: 2466296] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 999-1069. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| S63728 mRNA. Translation: AAB27517.2. M33425 mRNA. Translation: AAA40016.1. | |
| IPI | IPI00126078. |
| UniGene | Mm.289657 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1JQH based on UniProtKB P08069. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P52332. 1 interaction. |
| STRING | P52332. |
PTM databases | |
| PhosphoSite | P52332. |
Proteomic databases | |
| PRIDE | P52332. |
Genome annotation databases | |
| Ensembl | ENSMUST00000102781; ENSMUSP00000099842; ENSMUSG00000028530; Mus musculus. [Genome view] |
Organism-specific databases | |
| MGI | MGI:96628. Jak1. |
Phylogenomic databases | |
| HOGENOM | P52332. |
| HOVERGEN | P52332. |
Enzyme and pathway databases | |
| BRENDA | 2.7.10.2. 244. |
Gene expression databases | |
| ArrayExpress | P52332. |
| Bgee | P52332. |
| CleanEx | MM_JAK1. |
| Genevestigator | P52332. |
| GermOnline | ENSMUSG00000028530. Mus musculus. |
Family and domain databases | |
| InterPro | IPR019749. Band_41_domain. IPR019747. FERM_CS. IPR000299. FERM_domain. IPR009127. JAK. IPR009128. JAK1. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR000980. SH2. IPR001245. Tyr_pkinase. IPR008266. Tyr_pkinase_AS. IPR016251. TyrPK_Jak. [Graphical view] |
| Pfam | PF07714. Pkinase_Tyr. 2 hits. [Graphical view] |
| PIRSF | PIRSF000636. TyrPK_Jak. 1 hit. |
| PRINTS | PR01823. JANUSKINASE. PR01824. JANUSKINASE1. PR00109. TYRKINASE. |
| ProDom | PD000001. Prot_kinase. 2 hits. PD000093. SH2. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00295. B41. 1 hit. SM00252. SH2. 1 hit. SM00219. TyrKc. 2 hits. [Graphical view] |
| PROSITE | PS00660. FERM_1. False negative. PS00661. FERM_2. False negative. PS50057. FERM_3. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 2 hits. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS50001. SH2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| SOURCE | Search... |
Entry information
| Entry name | JAK1_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P52332 Secondary accession number(s): Q62126 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| Human and mouse protein kinases Human and mouse protein kinases: classification and index |
| SIMILARITY comments Index of protein domains and families |

Clusters with


