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Protein

Streptogrisin-C

Gene

sprC

Organism
Streptomyces griseus
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Hydrolysis of proteins with specificity similar to chymotrypsin. May be specialized for the degradation of chitin-linked proteins. Has a primary specificity for large aliphatic or aromatic amino acids.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei238 – 2381Charge relay system
Active sitei266 – 2661Charge relay system
Active sitei347 – 3471Charge relay system

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

CAZyiCBM12. Carbohydrate-Binding Module Family 12.
MEROPSiS01.265.

Names & Taxonomyi

Protein namesi
Recommended name:
Streptogrisin-C (EC:3.4.21.-)
Alternative name(s):
SGPC
Serine protease C
Gene namesi
Name:sprC
OrganismiStreptomyces griseus
Taxonomic identifieri1911 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Tat-type signalPROSITE-ProRule annotationAdd
BLAST
Propeptidei35 – 202168Sequence analysisPRO_0000026913Add
BLAST
Chaini203 – 457255Streptogrisin-CPRO_0000026914Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi219 ↔ 239By similarity
Disulfide bondi305 ↔ 315By similarity
Disulfide bondi341 ↔ 368By similarity

Post-translational modificationi

Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

Keywords - PTMi

Disulfide bond, Zymogen

Interactioni

Subunit structurei

Monomer.Curated

Protein-protein interaction databases

STRINGi455632.SGR_4060.

Structurei

3D structure databases

ProteinModelPortaliP52320.
SMRiP52320. Positions 414-455.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini415 – 45743Chitin-binding type-3Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni203 – 393191CatalyticAdd
BLAST
Regioni394 – 41320LinkerAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.Curated
Contains 1 chitin-binding type-3 domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4106T9R. Bacteria.
ENOG410XQ6H. LUCA.

Family and domain databases

Gene3Di2.10.10.20. 1 hit.
InterProiIPR003610. CBM_fam5/12.
IPR004236. Pept_S1_alpha_lytic.
IPR001316. Pept_S1A_streptogrisin.
IPR009003. Peptidase_S1_PA.
IPR006311. TAT_signal.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF02839. CBM_5_12. 1 hit.
PF02983. Pro_Al_protease. 1 hit.
[Graphical view]
PIRSFiPIRSF001134. Streptogrisin. 1 hit.
PRINTSiPR00861. ALYTICPTASE.
SMARTiSM00495. ChtBD3. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF51055. SSF51055. 1 hit.
PROSITEiPS51318. TAT. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52320-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERTTLRRRA LVAGTATVAV GALALAGLTG VASADPAATA APPVSADSLS
60 70 80 90 100
PGMLAALERD LGLDEDAARS RIANEYRAAA VAAGLEKSLG ARYAGARVSG
110 120 130 140 150
AKATLTVATT DASEAARITE AGARAEVVGH SLDRFEGVKK SLDKAALDKA
160 170 180 190 200
PKNVPVWYVD VAANRVVVNA ASPAAGQAFL KVAGVDRGLV TVARSAEQPR
210 220 230 240 250
ALADIRGGDA YYMNGSGRCS VGFSVTRGTQ NGFATAGHCG RVGTTTNGVN
260 270 280 290 300
QQAQGTFQGS TFPGRDIAWV ATNANWTPRP LVNGYGRGDV TVAGSTASVV
310 320 330 340 350
GASVCRSGST TGWHCGTIQQ LNTSVTYPEG TISGVTRTSV CAEPGDSGGS
360 370 380 390 400
YISGSQAQGV TSGGSGNCSS GGTTYFQPIN PLLQAYGLTL VTSGGGTPTD
410 420 430 440 450
PPTTPPTDSP GGTWAVGTAY AAGATVTYGG ATYRCLQAHT AQPGWTPADV

PALWQRV
Length:457
Mass (Da):46,029
Last modified:October 1, 1996 - v1
Checksum:i563A441560322209
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29018 Genomic DNA. Translation: AAA26813.1.
PIRiA53669.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29018 Genomic DNA. Translation: AAA26813.1.
PIRiA53669.

3D structure databases

ProteinModelPortaliP52320.
SMRiP52320. Positions 414-455.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi455632.SGR_4060.

Protein family/group databases

CAZyiCBM12. Carbohydrate-Binding Module Family 12.
MEROPSiS01.265.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4106T9R. Bacteria.
ENOG410XQ6H. LUCA.

Family and domain databases

Gene3Di2.10.10.20. 1 hit.
InterProiIPR003610. CBM_fam5/12.
IPR004236. Pept_S1_alpha_lytic.
IPR001316. Pept_S1A_streptogrisin.
IPR009003. Peptidase_S1_PA.
IPR006311. TAT_signal.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF02839. CBM_5_12. 1 hit.
PF02983. Pro_Al_protease. 1 hit.
[Graphical view]
PIRSFiPIRSF001134. Streptogrisin. 1 hit.
PRINTSiPR00861. ALYTICPTASE.
SMARTiSM00495. ChtBD3. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF51055. SSF51055. 1 hit.
PROSITEiPS51318. TAT. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRTC_STRGR
AccessioniPrimary (citable) accession number: P52320
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 16, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.