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P52311

- MTX2_XANOR

UniProt

P52311 - MTX2_XANOR

Protein

Modification methylase XorII

Gene

xorIIM

Organism
Xanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 2 (29 Mar 2005)
      Previous versions | rss
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    Functioni

    This methylase recognizes the double-stranded sequence CGATCG, causes specific methylation on C-? on both strands and protects the DNA from cleavage by the XorII endonuclease.

    Catalytic activityi

    S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei83 – 831PROSITE-ProRule annotation

    GO - Molecular functioni

    1. DNA (cytosine-5-)-methyltransferase activity Source: UniProtKB-EC
    2. DNA binding Source: InterPro

    GO - Biological processi

    1. DNA restriction-modification system Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Restriction system

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciXORY291331:GJBV-552-MONOMER.

    Protein family/group databases

    REBASEi3534. M.XorII.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Modification methylase XorII (EC:2.1.1.37)
    Short name:
    M.XorII
    Alternative name(s):
    Cytosine-specific methyltransferase XorII
    Gene namesi
    Name:xorIIM
    Ordered Locus Names:XOO0607
    OrganismiXanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85)
    Taxonomic identifieri291331 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
    ProteomesiUP000006735: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 424424Modification methylase XorIIPRO_0000087910Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi291331.XOO0607.

    Structurei

    3D structure databases

    ProteinModelPortaliP52311.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 367364SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation
    Contains 1 SAM-dependent MTase C5-type domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0270.
    HOGENOMiHOG000225505.
    KOiK00558.
    OrthoDBiEOG6JQH0N.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR018117. C5_DNA_meth_AS.
    IPR001525. C5_MeTfrase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PANTHERiPTHR10629. PTHR10629. 1 hit.
    PfamiPF00145. DNA_methylase. 1 hit.
    [Graphical view]
    PRINTSiPR00105. C5METTRFRASE.
    SUPFAMiSSF53335. SSF53335. 2 hits.
    TIGRFAMsiTIGR00675. dcm. 1 hit.
    PROSITEiPS00094. C5_MTASE_1. 1 hit.
    PS00095. C5_MTASE_2. 1 hit.
    PS51679. SAM_MT_C5. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P52311-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTRPIGIDLF AGAGGLSLGF EQAGFDLVAA VDIDPIHCAA HKFNFPKCAT    50
    VCKSVVDVTG DELRRIAGIG KRDIDIVIGG APCQGFSLIG KRALDDSRNQ 100
    LVHHYVRVVM ELKPKYFVFE NVKGLTVGKH RQFLKEVIEA FQNGGYDVVT 150
    DYRVLNAADY GVPQDRRRLI LMGARKGLPL PAYPEPTGRT TVGDAIGDIP 200
    DAESFPELWE RDWVKAKYGK PSTYAAYLRG KKDDPTDFGY RRQFDPMLLT 250
    GSLLTDHTEL SRQRFAAIAP DDVEPVSRFK KLALNGICNT LRAGTASDRG 300
    AFTSPRPIHP TVPRVITVRE AARLHSYPDW FRFHATKWHG FRQIGNSVPP 350
    LLARAVGGQI MKALRKKPEK PSEMLALGDQ SLIGISMTDA AAMFGVSSTV 400
    IARRSRPVDR PAPRRHEERE LVTA 424
    Length:424
    Mass (Da):46,900
    Last modified:March 29, 2005 - v2
    Checksum:iEBC3FD08DBACADEC
    GO

    Sequence cautioni

    The sequence AAW73861.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti60 – 612GD → RS in AAA50432. (PubMed:8078464)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U06424 Genomic DNA. Translation: AAA50432.1.
    AE013598 Genomic DNA. Translation: AAW73861.1. Different initiation.
    PIRiS46293.
    RefSeqiYP_199246.1. NC_006834.1.

    Genome annotation databases

    EnsemblBacteriaiAAW73861; AAW73861; XOO0607.
    GeneIDi3264300.
    KEGGixoo:XOO0607.
    PATRICi24100062. VBIXanOry111333_0681.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U06424 Genomic DNA. Translation: AAA50432.1 .
    AE013598 Genomic DNA. Translation: AAW73861.1 . Different initiation.
    PIRi S46293.
    RefSeqi YP_199246.1. NC_006834.1.

    3D structure databases

    ProteinModelPortali P52311.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 291331.XOO0607.

    Protein family/group databases

    REBASEi 3534. M.XorII.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAW73861 ; AAW73861 ; XOO0607 .
    GeneIDi 3264300.
    KEGGi xoo:XOO0607.
    PATRICi 24100062. VBIXanOry111333_0681.

    Phylogenomic databases

    eggNOGi COG0270.
    HOGENOMi HOG000225505.
    KOi K00558.
    OrthoDBi EOG6JQH0N.

    Enzyme and pathway databases

    BioCyci XORY291331:GJBV-552-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR018117. C5_DNA_meth_AS.
    IPR001525. C5_MeTfrase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    PANTHERi PTHR10629. PTHR10629. 1 hit.
    Pfami PF00145. DNA_methylase. 1 hit.
    [Graphical view ]
    PRINTSi PR00105. C5METTRFRASE.
    SUPFAMi SSF53335. SSF53335. 2 hits.
    TIGRFAMsi TIGR00675. dcm. 1 hit.
    PROSITEi PS00094. C5_MTASE_1. 1 hit.
    PS00095. C5_MTASE_2. 1 hit.
    PS51679. SAM_MT_C5. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of the XorII methyltransferase gene and a vsr homolog from Xanthomonas oryzae pv. oryzae."
      Choi S.H., Leach J.E.
      Mol. Gen. Genet. 244:383-390(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: JW89011.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KACC10331 / KXO85.

    Entry informationi

    Entry nameiMTX2_XANOR
    AccessioniPrimary (citable) accession number: P52311
    Secondary accession number(s): Q5H5A9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: March 29, 2005
    Last modified: October 1, 2014
    This is version 85 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Restriction enzymes and methylases
      Classification of restriction enzymes and methylases and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3