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P52311 (MTX2_XANOR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Modification methylase XorII

Short name=M.XorII
EC=2.1.1.37
Alternative name(s):
Cytosine-specific methyltransferase XorII
Gene names
Name:xorIIM
Ordered Locus Names:XOO0607
OrganismXanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85) [Complete proteome] [HAMAP]
Taxonomic identifier291331 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas

Protein attributes

Sequence length424 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This methylase recognizes the double-stranded sequence CGATCG, causes specific methylation on C-? on both strands and protects the DNA from cleavage by the XorII endonuclease.

Catalytic activity

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

Contains 1 SAM-dependent MTase C5-type domain.

Sequence caution

The sequence AAW73861.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processRestriction system
   LigandS-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processDNA restriction-modification system

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionDNA (cytosine-5-)-methyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

DNA binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 424424Modification methylase XorII
PRO_0000087910

Regions

Domain4 – 367364SAM-dependent MTase C5-type

Sites

Active site831 By similarity

Experimental info

Sequence conflict60 – 612GD → RS in AAA50432. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P52311 [UniParc].

Last modified March 29, 2005. Version 2.
Checksum: EBC3FD08DBACADEC

FASTA42446,900
        10         20         30         40         50         60 
MTRPIGIDLF AGAGGLSLGF EQAGFDLVAA VDIDPIHCAA HKFNFPKCAT VCKSVVDVTG 

        70         80         90        100        110        120 
DELRRIAGIG KRDIDIVIGG APCQGFSLIG KRALDDSRNQ LVHHYVRVVM ELKPKYFVFE 

       130        140        150        160        170        180 
NVKGLTVGKH RQFLKEVIEA FQNGGYDVVT DYRVLNAADY GVPQDRRRLI LMGARKGLPL 

       190        200        210        220        230        240 
PAYPEPTGRT TVGDAIGDIP DAESFPELWE RDWVKAKYGK PSTYAAYLRG KKDDPTDFGY 

       250        260        270        280        290        300 
RRQFDPMLLT GSLLTDHTEL SRQRFAAIAP DDVEPVSRFK KLALNGICNT LRAGTASDRG 

       310        320        330        340        350        360 
AFTSPRPIHP TVPRVITVRE AARLHSYPDW FRFHATKWHG FRQIGNSVPP LLARAVGGQI 

       370        380        390        400        410        420 
MKALRKKPEK PSEMLALGDQ SLIGISMTDA AAMFGVSSTV IARRSRPVDR PAPRRHEERE 


LVTA 

« Hide

References

« Hide 'large scale' references
[1]"Identification of the XorII methyltransferase gene and a vsr homolog from Xanthomonas oryzae pv. oryzae."
Choi S.H., Leach J.E.
Mol. Gen. Genet. 244:383-390(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: JW89011.
[2]"The genome sequence of Xanthomonas oryzae pathovar oryzae KACC10331, the bacterial blight pathogen of rice."
Lee B.-M., Park Y.-J., Park D.-S., Kang H.-W., Kim J.-G., Song E.-S., Park I.-C., Yoon U.-H., Hahn J.-H., Koo B.-S., Lee G.-B., Kim H., Park H.-S., Yoon K.-O., Kim J.-H., Jung C.-H., Koh N.-H., Seo J.-S., Go S.-J.
Nucleic Acids Res. 33:577-586(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KACC10331 / KXO85.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U06424 Genomic DNA. Translation: AAA50432.1.
AE013598 Genomic DNA. Translation: AAW73861.1. Different initiation.
PIRS46293.
RefSeqYP_199246.1. NC_006834.1.

3D structure databases

ProteinModelPortalP52311.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING291331.XOO0607.

Protein family/group databases

REBASE3534. M.XorII.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAW73861; AAW73861; XOO0607.
GeneID3264300.
KEGGxoo:XOO0607.
PATRIC24100062. VBIXanOry111333_0681.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0270.
HOGENOMHOG000225505.
KOK00558.
OrthoDBEOG6JQH0N.
ProtClustDBCLSK880091.

Enzyme and pathway databases

BioCycXORY291331:GJBV-552-MONOMER.

Family and domain databases

InterProIPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
[Graphical view]
PANTHERPTHR10629. PTHR10629. 1 hit.
PfamPF00145. DNA_methylase. 1 hit.
[Graphical view]
PRINTSPR00105. C5METTRFRASE.
TIGRFAMsTIGR00675. dcm. 1 hit.
PROSITEPS00094. C5_MTASE_1. 1 hit.
PS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTX2_XANOR
AccessionPrimary (citable) accession number: P52311
Secondary accession number(s): Q5H5A9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: March 29, 2005
Last modified: April 16, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Restriction enzymes and methylases

Classification of restriction enzymes and methylases and list of entries