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P52311

- MTX2_XANOR

UniProt

P52311 - MTX2_XANOR

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Protein

Modification methylase XorII

Gene

xorIIM

Organism
Xanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence CGATCG, causes specific methylation on C-? on both strands and protects the DNA from cleavage by the XorII endonuclease.

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei83 – 831PROSITE-ProRule annotation

GO - Molecular functioni

  1. DNA (cytosine-5-)-methyltransferase activity Source: UniProtKB-EC
  2. DNA binding Source: InterPro

GO - Biological processi

  1. DNA restriction-modification system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Restriction system

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciXORY291331:GJBV-552-MONOMER.

Protein family/group databases

REBASEi3534. M.XorII.

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase XorII (EC:2.1.1.37)
Short name:
M.XorII
Alternative name(s):
Cytosine-specific methyltransferase XorII
Gene namesi
Name:xorIIM
Ordered Locus Names:XOO0607
OrganismiXanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85)
Taxonomic identifieri291331 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
ProteomesiUP000006735: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 424424Modification methylase XorIIPRO_0000087910Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi291331.XOO0607.

Structurei

3D structure databases

ProteinModelPortaliP52311.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 367364SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation
Contains 1 SAM-dependent MTase C5-type domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0270.
HOGENOMiHOG000225505.
KOiK00558.
OrthoDBiEOG6JQH0N.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PANTHERiPTHR10629. PTHR10629. 1 hit.
PfamiPF00145. DNA_methylase. 1 hit.
[Graphical view]
PRINTSiPR00105. C5METTRFRASE.
SUPFAMiSSF53335. SSF53335. 2 hits.
TIGRFAMsiTIGR00675. dcm. 1 hit.
PROSITEiPS00094. C5_MTASE_1. 1 hit.
PS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52311-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTRPIGIDLF AGAGGLSLGF EQAGFDLVAA VDIDPIHCAA HKFNFPKCAT
60 70 80 90 100
VCKSVVDVTG DELRRIAGIG KRDIDIVIGG APCQGFSLIG KRALDDSRNQ
110 120 130 140 150
LVHHYVRVVM ELKPKYFVFE NVKGLTVGKH RQFLKEVIEA FQNGGYDVVT
160 170 180 190 200
DYRVLNAADY GVPQDRRRLI LMGARKGLPL PAYPEPTGRT TVGDAIGDIP
210 220 230 240 250
DAESFPELWE RDWVKAKYGK PSTYAAYLRG KKDDPTDFGY RRQFDPMLLT
260 270 280 290 300
GSLLTDHTEL SRQRFAAIAP DDVEPVSRFK KLALNGICNT LRAGTASDRG
310 320 330 340 350
AFTSPRPIHP TVPRVITVRE AARLHSYPDW FRFHATKWHG FRQIGNSVPP
360 370 380 390 400
LLARAVGGQI MKALRKKPEK PSEMLALGDQ SLIGISMTDA AAMFGVSSTV
410 420
IARRSRPVDR PAPRRHEERE LVTA
Length:424
Mass (Da):46,900
Last modified:March 29, 2005 - v2
Checksum:iEBC3FD08DBACADEC
GO

Sequence cautioni

The sequence AAW73861.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti60 – 612GD → RS in AAA50432. (PubMed:8078464)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06424 Genomic DNA. Translation: AAA50432.1.
AE013598 Genomic DNA. Translation: AAW73861.1. Different initiation.
PIRiS46293.
RefSeqiYP_199246.1. NC_006834.1.

Genome annotation databases

EnsemblBacteriaiAAW73861; AAW73861; XOO0607.
GeneIDi3264300.
KEGGixoo:XOO0607.
PATRICi24100062. VBIXanOry111333_0681.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06424 Genomic DNA. Translation: AAA50432.1 .
AE013598 Genomic DNA. Translation: AAW73861.1 . Different initiation.
PIRi S46293.
RefSeqi YP_199246.1. NC_006834.1.

3D structure databases

ProteinModelPortali P52311.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 291331.XOO0607.

Protein family/group databases

REBASEi 3534. M.XorII.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAW73861 ; AAW73861 ; XOO0607 .
GeneIDi 3264300.
KEGGi xoo:XOO0607.
PATRICi 24100062. VBIXanOry111333_0681.

Phylogenomic databases

eggNOGi COG0270.
HOGENOMi HOG000225505.
KOi K00558.
OrthoDBi EOG6JQH0N.

Enzyme and pathway databases

BioCyci XORY291331:GJBV-552-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PANTHERi PTHR10629. PTHR10629. 1 hit.
Pfami PF00145. DNA_methylase. 1 hit.
[Graphical view ]
PRINTSi PR00105. C5METTRFRASE.
SUPFAMi SSF53335. SSF53335. 2 hits.
TIGRFAMsi TIGR00675. dcm. 1 hit.
PROSITEi PS00094. C5_MTASE_1. 1 hit.
PS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of the XorII methyltransferase gene and a vsr homolog from Xanthomonas oryzae pv. oryzae."
    Choi S.H., Leach J.E.
    Mol. Gen. Genet. 244:383-390(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: JW89011.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KACC10331 / KXO85.

Entry informationi

Entry nameiMTX2_XANOR
AccessioniPrimary (citable) accession number: P52311
Secondary accession number(s): Q5H5A9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: March 29, 2005
Last modified: October 1, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3