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Protein

Modification methylase XorII

Gene

xorIIM

Organism
Xanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence CGATCG, causes specific methylation on C-? on both strands and protects the DNA from cleavage by the XorII endonuclease.

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei83PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processRestriction system
LigandS-adenosyl-L-methionine

Protein family/group databases

REBASEi3534 M.XorII

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase XorII (EC:2.1.1.37)
Short name:
M.XorII
Alternative name(s):
Cytosine-specific methyltransferase XorII
Gene namesi
Name:xorIIM
Ordered Locus Names:XOO0607
OrganismiXanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85)
Taxonomic identifieri291331 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
Proteomesi
  • UP000006735 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000879101 – 424Modification methylase XorIIAdd BLAST424

Proteomic databases

PRIDEiP52311

Structurei

3D structure databases

ProteinModelPortaliP52311
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 367SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd BLAST364

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000225505
KOiK00558

Family and domain databases

InterProiView protein in InterPro
IPR018117 C5_DNA_meth_AS
IPR001525 C5_MeTfrase
IPR031303 C5_meth_CS
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF00145 DNA_methylase, 1 hit
PRINTSiPR00105 C5METTRFRASE
SUPFAMiSSF53335 SSF53335, 2 hits
TIGRFAMsiTIGR00675 dcm, 1 hit
PROSITEiView protein in PROSITE
PS00094 C5_MTASE_1, 1 hit
PS00095 C5_MTASE_2, 1 hit
PS51679 SAM_MT_C5, 1 hit

Sequencei

Sequence statusi: Complete.

P52311-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRPIGIDLF AGAGGLSLGF EQAGFDLVAA VDIDPIHCAA HKFNFPKCAT
60 70 80 90 100
VCKSVVDVTG DELRRIAGIG KRDIDIVIGG APCQGFSLIG KRALDDSRNQ
110 120 130 140 150
LVHHYVRVVM ELKPKYFVFE NVKGLTVGKH RQFLKEVIEA FQNGGYDVVT
160 170 180 190 200
DYRVLNAADY GVPQDRRRLI LMGARKGLPL PAYPEPTGRT TVGDAIGDIP
210 220 230 240 250
DAESFPELWE RDWVKAKYGK PSTYAAYLRG KKDDPTDFGY RRQFDPMLLT
260 270 280 290 300
GSLLTDHTEL SRQRFAAIAP DDVEPVSRFK KLALNGICNT LRAGTASDRG
310 320 330 340 350
AFTSPRPIHP TVPRVITVRE AARLHSYPDW FRFHATKWHG FRQIGNSVPP
360 370 380 390 400
LLARAVGGQI MKALRKKPEK PSEMLALGDQ SLIGISMTDA AAMFGVSSTV
410 420
IARRSRPVDR PAPRRHEERE LVTA
Length:424
Mass (Da):46,900
Last modified:March 29, 2005 - v2
Checksum:iEBC3FD08DBACADEC
GO

Sequence cautioni

The sequence AAW73861 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti60 – 61GD → RS in AAA50432 (PubMed:8078464).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06424 Genomic DNA Translation: AAA50432.1
AE013598 Genomic DNA Translation: AAW73861.1 Different initiation.
PIRiS46293

Genome annotation databases

EnsemblBacteriaiAAW73861; AAW73861; XOO0607
KEGGixoo:XOO0607

Similar proteinsi

Entry informationi

Entry nameiMTX2_XANOR
AccessioniPrimary (citable) accession number: P52311
Secondary accession number(s): Q5H5A9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: March 29, 2005
Last modified: May 23, 2018
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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