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Protein

Rap1 GTPase-GDP dissociation stimulator 1

Gene

RAP1GDS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Stimulates GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins) including Rap1a/Rap1b, RhoA, RhoB and KRas, by stimulating the dissociation of GDP from and the subsequent binding of GTP to each small G protein.

GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB

GO - Biological processi

  • myosin filament assembly Source: Ensembl
  • negative regulation of endoplasmic reticulum calcium ion concentration Source: UniProtKB
  • positive regulation of mitochondrial calcium ion concentration Source: UniProtKB
  • vascular smooth muscle contraction Source: Ensembl

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

SignaLinkiP52306.
SIGNORiP52306.

Names & Taxonomyi

Protein namesi
Recommended name:
Rap1 GTPase-GDP dissociation stimulator 1
Alternative name(s):
Exchange factor smgGDS
SMG GDS protein
SMG P21 stimulatory GDP/GTP exchange protein
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:9859. RAP1GDS1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: UniProtKB
  • endoplasmic reticulum Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • mitochondrion Source: UniProtKB

Pathology & Biotechi

Organism-specific databases

DisGeNETi5910.
OpenTargetsiENSG00000138698.
PharmGKBiPA34221.

Polymorphism and mutation databases

BioMutaiRAP1GDS1.
DMDMi212276504.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000567591 – 607Rap1 GTPase-GDP dissociation stimulator 1Add BLAST607

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei230N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP52306.
MaxQBiP52306.
PaxDbiP52306.
PeptideAtlasiP52306.
PRIDEiP52306.

PTM databases

iPTMnetiP52306.
PhosphoSitePlusiP52306.
SwissPalmiP52306.

Expressioni

Gene expression databases

BgeeiENSG00000138698.
CleanExiHS_RAP1GDS1.
ExpressionAtlasiP52306. baseline and differential.
GenevisibleiP52306. HS.

Organism-specific databases

HPAiHPA019060.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi111845. 81 interactors.
DIPiDIP-61080N.
IntActiP52306. 18 interactors.
MINTiMINT-1464259.
STRINGi9606.ENSP00000340454.

Structurei

3D structure databases

ProteinModelPortaliP52306.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati77 – 118ARM 1Add BLAST42
Repeati169 – 211ARM 2Add BLAST43
Repeati346 – 390ARM 3Add BLAST45
Repeati391 – 431ARM 4Add BLAST41
Repeati479 – 519ARM 5Add BLAST41

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4500. Eukaryota.
ENOG410Z64F. LUCA.
GeneTreeiENSGT00390000014293.
HOGENOMiHOG000088636.
HOVERGENiHBG001622.
InParanoidiP52306.
OMAiMGSECLH.
OrthoDBiEOG091G06JW.
PhylomeDBiP52306.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
InterProiView protein in InterPro
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
PfamiView protein in Pfam
PF00514. Arm. 4 hits.
SMARTiView protein in SMART
SM00185. ARM. 5 hits.
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiView protein in PROSITE
PS50176. ARM_REPEAT. 2 hits.

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P52306-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDNLSDTLKK LKITAVDKTE DSLEGCLDCL LQALAQNNTE TSEKIQASGI
60 70 80 90 100
LQLFASLLTP QSSCKAKVAN IIAEVAKNEF MRIPCVDAGL ISPLVQLLNS
110 120 130 140 150
KDQEVLLQTG RALGNICYDS HEGRSAVDQA GGAQIVIDHL RSLCSITDPA
160 170 180 190 200
NEKLLTVFCG MLMNYSNEND SLQAQLINMG VIPTLVKLLG IHCQNAALTE
210 220 230 240 250
MCLVAFGNLA ELESSKEQFA STNIAEELVK LFKKQIEHDK REMIFEVLAP
260 270 280 290 300
LAENDAIKLQ LVEAGLVECL LEIVQQKVDS DKEDDITELK TGSDLMVLLL
310 320 330 340 350
LGDESMQKLF EGGKGSVFQR VLSWIPSNNH QLQLAGALAI ANFARNDANC
360 370 380 390 400
IHMVDNGIVE KLMDLLDRHV EDGNVTVQHA ALSALRNLAI PVINKAKMLS
410 420 430 440 450
AGVTEAVLKF LKSEMPPVQF KLLGTLRMLI DAQAEAAEQL GKNVKLVERL
460 470 480 490 500
VEWCEAKDHA GVMGESNRLL SALIRHSKSK DVIKTIVQSG GIKHLVTMAT
510 520 530 540 550
SEHVIMQNEA LVALALIAAL ELGTAEKDLE SAKLVQILHR LLADERSAPE
560 570 580 590 600
IKYNSMVLIC ALMGSECLHK EVQDLAFLDV VSKLRSHENK SVAQQASLTE

QRLTVES
Length:607
Mass (Da):66,317
Last modified:November 4, 2008 - v3
Checksum:iED0F359DFA3F0510
GO
Isoform 2 (identifier: P52306-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     122-170: Missing.

Show »
Length:558
Mass (Da):61,037
Checksum:i7DCE981DA08F4629
GO
Isoform 3 (identifier: P52306-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MA
     122-170: Missing.

Note: No experimental confirmation available.
Show »
Length:559
Mass (Da):61,108
Checksum:i2BF086E5908DC6BD
GO
Isoform 4 (identifier: P52306-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MA
     434-434: Missing.

Note: No experimental confirmation available.
Show »
Length:607
Mass (Da):66,317
Checksum:i8196856D628A428C
GO
Isoform 5 (identifier: P52306-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MA

Show »
Length:608
Mass (Da):66,388
Checksum:iB73C1010A184A971
GO
Isoform 6 (identifier: P52306-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MA
     121-213: HEGRSAVDQA...VAFGNLAELE → Q

Note: No experimental confirmation available.
Show »
Length:516
Mass (Da):56,536
Checksum:iD508C3FD684CA75D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti237E → G in AAH98269 (PubMed:15489334).Curated1
Sequence conflicti376T → P in AAF43211 (Ref. 3) Curated1
Sequence conflicti394N → D in CAA45067 (PubMed:1549351).Curated1
Sequence conflicti394N → D in AAF32290 (PubMed:11948427).Curated1
Sequence conflicti593A → R in CAA45067 (PubMed:1549351).Curated1
Sequence conflicti593A → R in AAF32290 (PubMed:11948427).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06914956S → T1 PublicationCorresponds to variant dbSNP:rs17849535Ensembl.1
Natural variantiVAR_049158314K → E. Corresponds to variant dbSNP:rs34392334Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0436601M → MA in isoform 3, isoform 4, isoform 5 and isoform 6. 1 Publication1
Alternative sequenceiVSP_047041121 – 213HEGRS…LAELE → Q in isoform 6. CuratedAdd BLAST93
Alternative sequenceiVSP_001658122 – 170Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST49
Alternative sequenceiVSP_046214434Missing in isoform 4. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63465 mRNA. Translation: CAA45067.1.
AF215923 mRNA. Translation: AAF32290.1.
AF237413 mRNA. Translation: AAF43211.1.
AC019077 Genomic DNA. No translation available.
AC058823 Genomic DNA. No translation available.
AC078961 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX06069.1.
CH471057 Genomic DNA. Translation: EAX06071.1.
BC001816 mRNA. Translation: AAH01816.1.
BC001851 mRNA. Translation: AAH01851.2.
BT006837 mRNA. Translation: AAP35483.1.
BC098269 mRNA. Translation: AAH98269.1.
BC098334 mRNA. Translation: AAH98334.1.
BC099708 mRNA. Translation: AAH99708.1.
BC099845 mRNA. Translation: AAH99845.1.
CCDSiCCDS43253.1. [P52306-1]
CCDS43254.1. [P52306-2]
CCDS47105.1. [P52306-5]
CCDS47106.1. [P52306-4]
CCDS47107.1. [P52306-3]
CCDS47108.1. [P52306-6]
PIRiI37456.
RefSeqiNP_001093896.1. NM_001100426.1. [P52306-5]
NP_001093897.1. NM_001100427.1. [P52306-1]
NP_001093898.1. NM_001100428.1. [P52306-3]
NP_001093899.1. NM_001100429.1. [P52306-2]
NP_001093900.1. NM_001100430.1. [P52306-6]
NP_066982.3. NM_021159.4. [P52306-4]
UniGeneiHs.132858.

Genome annotation databases

EnsembliENST00000264572; ENSP00000264572; ENSG00000138698. [P52306-6]
ENST00000339360; ENSP00000340454; ENSG00000138698. [P52306-5]
ENST00000380158; ENSP00000369503; ENSG00000138698. [P52306-3]
ENST00000408900; ENSP00000386223; ENSG00000138698. [P52306-2]
ENST00000408927; ENSP00000386153; ENSG00000138698. [P52306-1]
ENST00000453712; ENSP00000407157; ENSG00000138698. [P52306-4]
GeneIDi5910.
KEGGihsa:5910.
UCSCiuc003htv.5. human. [P52306-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63465 mRNA. Translation: CAA45067.1.
AF215923 mRNA. Translation: AAF32290.1.
AF237413 mRNA. Translation: AAF43211.1.
AC019077 Genomic DNA. No translation available.
AC058823 Genomic DNA. No translation available.
AC078961 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX06069.1.
CH471057 Genomic DNA. Translation: EAX06071.1.
BC001816 mRNA. Translation: AAH01816.1.
BC001851 mRNA. Translation: AAH01851.2.
BT006837 mRNA. Translation: AAP35483.1.
BC098269 mRNA. Translation: AAH98269.1.
BC098334 mRNA. Translation: AAH98334.1.
BC099708 mRNA. Translation: AAH99708.1.
BC099845 mRNA. Translation: AAH99845.1.
CCDSiCCDS43253.1. [P52306-1]
CCDS43254.1. [P52306-2]
CCDS47105.1. [P52306-5]
CCDS47106.1. [P52306-4]
CCDS47107.1. [P52306-3]
CCDS47108.1. [P52306-6]
PIRiI37456.
RefSeqiNP_001093896.1. NM_001100426.1. [P52306-5]
NP_001093897.1. NM_001100427.1. [P52306-1]
NP_001093898.1. NM_001100428.1. [P52306-3]
NP_001093899.1. NM_001100429.1. [P52306-2]
NP_001093900.1. NM_001100430.1. [P52306-6]
NP_066982.3. NM_021159.4. [P52306-4]
UniGeneiHs.132858.

3D structure databases

ProteinModelPortaliP52306.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111845. 81 interactors.
DIPiDIP-61080N.
IntActiP52306. 18 interactors.
MINTiMINT-1464259.
STRINGi9606.ENSP00000340454.

PTM databases

iPTMnetiP52306.
PhosphoSitePlusiP52306.
SwissPalmiP52306.

Polymorphism and mutation databases

BioMutaiRAP1GDS1.
DMDMi212276504.

Proteomic databases

EPDiP52306.
MaxQBiP52306.
PaxDbiP52306.
PeptideAtlasiP52306.
PRIDEiP52306.

Protocols and materials databases

DNASUi5910.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264572; ENSP00000264572; ENSG00000138698. [P52306-6]
ENST00000339360; ENSP00000340454; ENSG00000138698. [P52306-5]
ENST00000380158; ENSP00000369503; ENSG00000138698. [P52306-3]
ENST00000408900; ENSP00000386223; ENSG00000138698. [P52306-2]
ENST00000408927; ENSP00000386153; ENSG00000138698. [P52306-1]
ENST00000453712; ENSP00000407157; ENSG00000138698. [P52306-4]
GeneIDi5910.
KEGGihsa:5910.
UCSCiuc003htv.5. human. [P52306-1]

Organism-specific databases

CTDi5910.
DisGeNETi5910.
GeneCardsiRAP1GDS1.
H-InvDBHIX0004387.
HGNCiHGNC:9859. RAP1GDS1.
HPAiHPA019060.
MIMi179502. gene.
neXtProtiNX_P52306.
OpenTargetsiENSG00000138698.
PharmGKBiPA34221.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4500. Eukaryota.
ENOG410Z64F. LUCA.
GeneTreeiENSGT00390000014293.
HOGENOMiHOG000088636.
HOVERGENiHBG001622.
InParanoidiP52306.
OMAiMGSECLH.
OrthoDBiEOG091G06JW.
PhylomeDBiP52306.

Enzyme and pathway databases

SignaLinkiP52306.
SIGNORiP52306.

Miscellaneous databases

ChiTaRSiRAP1GDS1. human.
GeneWikiiRAP1GDS1.
GenomeRNAii5910.
PROiP52306.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138698.
CleanExiHS_RAP1GDS1.
ExpressionAtlasiP52306. baseline and differential.
GenevisibleiP52306. HS.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
InterProiView protein in InterPro
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
PfamiView protein in Pfam
PF00514. Arm. 4 hits.
SMARTiView protein in SMART
SM00185. ARM. 5 hits.
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiView protein in PROSITE
PS50176. ARM_REPEAT. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiGDS1_HUMAN
AccessioniPrimary (citable) accession number: P52306
Secondary accession number(s): E9PH06
, G5E9P9, Q499L7, Q4KMV2, Q4QQI8, Q9BUW9, Q9BUX6, Q9NYM2, Q9NZA8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 4, 2008
Last modified: March 15, 2017
This is version 139 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.