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Protein

Protein lethal(3)malignant blood neoplasm 1

Gene

l(3)mbn

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Required for differentiation of the phagocytic blood-cell type, the plasmatocyte.1 Publication

GO - Molecular functioni

GO - Biological processi

  • chaeta development Source: FlyBase
  • chitin-based cuticle development Source: FlyBase
  • wing disc development Source: FlyBase

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lethal(3)malignant blood neoplasm 1
Alternative name(s):
Mbn(83)
Gene namesi
Name:l(3)mbn
Synonyms:l(3)mbn-1
ORF Names:CG12755
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0002440. l(3)mbn.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001961821 – 653Protein lethal(3)malignant blood neoplasm 1Add BLAST653

Proteomic databases

PaxDbiP52302.
PRIDEiP52302.

Expressioni

Tissue specificityi

Blood cells and other tissues.1 Publication

Gene expression databases

BgeeiFBgn0002440.
ExpressionAtlasiP52302. differential.
GenevisibleiP52302. DM.

Interactioni

Protein-protein interaction databases

BioGridi64156. 4 interactors.
STRINGi7227.FBpp0076770.

Structurei

3D structure databases

SMRiP52302.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 91Chitin-binding type R&R 1PROSITE-ProRule annotationAdd BLAST64
Repeati307 – 3271-1Add BLAST21
Repeati328 – 3481-2Add BLAST21
Repeati433 – 4552-1Add BLAST23
Repeati456 – 4752-2Add BLAST20
Repeati476 – 4972-3Add BLAST22
Repeati498 – 5152-4Add BLAST18
Repeati516 – 5332-5Add BLAST18
Repeati534 – 5512-6Add BLAST18
Repeati552 – 5682-7Add BLAST17
Domaini572 – 640Chitin-binding type R&R 2PROSITE-ProRule annotationAdd BLAST69

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni307 – 3482 X 21 AA repeatsAdd BLAST42
Regioni433 – 5687 X approximate tandem repeats, Gly/Ser-richAdd BLAST136

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J4ZH. Eukaryota.
ENOG4112CT1. LUCA.
InParanoidiP52302.
OMAiFTIDEQQ.
OrthoDBiEOG091G0TWV.
PhylomeDBiP52302.

Family and domain databases

InterProiView protein in InterPro
IPR000618. Insect_cuticle.
PfamiView protein in Pfam
PF00379. Chitin_bind_4. 1 hit.
PROSITEiView protein in PROSITE
PS51155. CHIT_BIND_RR_2. 2 hits.

Sequencei

Sequence statusi: Complete.

P52302-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLKLMAFVC ALLLLCTLTH VLSAATTVRP YKFGFTIDEQ QHRAEKRDER
60 70 80 90 100
GIIMGEFGFI TADGIYHVTV YATDEEGKFR IISMKSYPYA GPVGSKSVPV
110 120 130 140 150
TTTPKVLLPA APVALPKYNF NSEACSGCFL KKSPPKTEIR TLSQPLAPVQ
160 170 180 190 200
PGKPDGSSDI GLNVQLPFRE SIAQTVASRL GLLQDTLQTS NTNTNAPNTK
210 220 230 240 250
TIELGLNIAM STYYTTKNAV TGHVSTQTSN SQTPSANTKI DYNVGVVEKA
260 270 280 290 300
SPPVYRPLNI RLNEDVMRQA ITYGNTIPGH VPLPNQPLVE TSLLPASQVK
310 320 330 340 350
IFALDGNAKV PLASNIQSVA QHPNAGLNAK VPLASNIQSV AQHPNAGLNA
360 370 380 390 400
KVPLASNIQS VAQHPNAGLK NINRSGVSSA KTLANTKTRP PHTFNPHQTP
410 420 430 440 450
LLSSATAPGI SGVTANTPTG NVPSNGGGIA AGKAPGNPQA GGSGGIIGAG
460 470 480 490 500
APGGRKVSAG GIGSGSAIGG VSGGSKASGN GGAIGSGSAI GGGATGSKAS
510 520 530 540 550
GFGFGSNIGG GVSGSKPSGF GSESKIGGPD SGSKALGFGS GSKIGGGITG
560 570 580 590 600
TKASGFGGEI GSGRGSASSA TGDLYKFKYI LDYNGHEETG GRNGDKQGSY
610 620 630 640 650
FAIGEDAVQR TIEYIANEFG FQPHVSWRKL DAKEALPEEN SLKHYEFKWF

NQE
Length:653
Mass (Da):67,144
Last modified:February 2, 2004 - v2
Checksum:iD2303B9FE417F81E
GO

Sequence cautioni

The sequence AAM50879 differs from that shown. Intron retention.Curated
The sequence CAA87654 differs from that shown. Reason: Frameshift at positions 2 and 16.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti56E → Q in CAA87654 (PubMed:8174791).Curated1
Sequence conflicti67H → Q in CAA87654 (PubMed:8174791).Curated1
Sequence conflicti72A → P in CAA87654 (PubMed:8174791).Curated1
Sequence conflicti109P → H in CAA87654 (PubMed:8174791).Curated1
Sequence conflicti189T → A in CAA87654 (PubMed:8174791).Curated1
Sequence conflicti208I → L in CAA87654 (PubMed:8174791).Curated1
Sequence conflicti226T → R in CAA87654 (PubMed:8174791).Curated1
Sequence conflicti422V → A in CAA87654 (PubMed:8174791).Curated1
Sequence conflicti529P → A in CAA87654 (PubMed:8174791).Curated1
Sequence conflicti536L → S in CAA87654 (PubMed:8174791).Curated1
Sequence conflicti556F → L in CAA87654 (PubMed:8174791).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47722 Genomic DNA. Translation: CAA87654.1. Frameshift.
AE014296 Genomic DNA. Translation: AAN12238.2.
AY119019 mRNA. Translation: AAM50879.1. Sequence problems.
PIRiS57844.
RefSeqiNP_729143.2. NM_168157.2.
UniGeneiDm.861.

Genome annotation databases

EnsemblMetazoaiFBtr0077062; FBpp0076770; FBgn0002440.
FBtr0346811; FBpp0312386; FBgn0002440.
GeneIDi38701.
KEGGidme:Dmel_CG12755.

Similar proteinsi

Entry informationi

Entry nameiMBN_DROME
AccessioniPrimary (citable) accession number: P52302
Secondary accession number(s): Q59E19, Q8MS87, Q9VRU6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: February 2, 2004
Last modified: September 27, 2017
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase