ID   RAN_XENLA               Reviewed;         216 AA.
AC   P52301; Q7ZYT6; Q9IBE8;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 2.
DT   24-NOV-2009, entry version 67.
DE   RecName: Full=GTP-binding nuclear protein Ran;
DE   AltName: Full=GTPase Ran;
DE   AltName: Full=Ras-related nuclear protein;
DE   AltName: Full=Ras-like protein TC4;
GN   Name=ran;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae;
OC   Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=21110526; PubMed=11180838; DOI=10.1007/s004270050320;
RA   Onuma Y., Nishihara R., Takahashi S., Tanegashima K., Fukui A.,
RA   Asashima M.;
RT   "Expression of the Xenopus GTP-binding protein gene Ran during
RT   embryogenesis.";
RL   Dev. Genes Evol. 210:325-327(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   PROTEIN SEQUENCE OF 40-52 AND 62-71.
RC   TISSUE=Ovary;
RX   MEDLINE=94019818; PubMed=8413630; DOI=10.1038/365661a0;
RA   Moore M.S., Blobel G.;
RT   "The GTP-binding protein Ran/TC4 is required for protein import into
RT   the nucleus.";
RL   Nature 365:661-663(1993).
CC   -!- FUNCTION: GTP-binding protein involved in nucleocytoplasmic
CC       transport. Required for the import of protein into the nucleus and
CC       also for RNA export. Involved in chromatin condensation and
CC       control of cell cycle (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Ran family.
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DR   EMBL; AB030945; BAA89696.1; -; mRNA.
DR   EMBL; BC041293; AAH41293.1; -; mRNA.
DR   RefSeq; NP_001080182.1; -.
DR   RefSeq; NP_001128547.1; -.
DR   UniGene; Xl.55052; -.
DR   UniGene; Xl.57143; -.
DR   SMR; P52301; 2-216.
DR   GeneID; 100189578; -.
DR   GeneID; 379874; -.
DR   KEGG; xla:100189578; -.
DR   KEGG; xla:379874; -.
DR   CTD; 100189578; -.
DR   CTD; 379874; -.
DR   Xenbase; XB-FEAT-489467; ran.
DR   HOVERGEN; P52301; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0005515; F:protein binding; IPI:UniProtKB.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   GO; GO:0006913; P:nucleocytoplasmic transport; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   InterPro; IPR002041; Ran_GTPase.
DR   InterPro; IPR013753; Ras.
DR   InterPro; IPR005225; Small_GTP_bd.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00627; GTPRANTC4.
DR   SMART; SM00176; RAN; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51418; RAN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; GTP-binding; Nucleotide-binding; Nucleus;
KW   Protein transport; Transport.
FT   CHAIN         1    216       GTP-binding nuclear protein Ran.
FT                                /FTId=PRO_0000208702.
FT   NP_BIND      17     24       GTP (By similarity).
FT   NP_BIND      65     69       GTP (By similarity).
FT   NP_BIND     122    125       GTP (By similarity).
FT   CONFLICT    199    199       Q -> A (in Ref. 2; AAH41293).
SQ   SEQUENCE   216 AA;  24398 MW;  D5DB10D65C2AD5A4 CRC64;
     MAAQGEPQVQ FKLVLVGDGG TGKTTFVKRH LTGEFEKKYV ATLGVEVHPL VFHTNRGPIK
     FNVWDTAGQE KFGGLRDGYY IQAQCAIIMF DVTSRVTYKN VPNWHRDLVR VCENIPIVLC
     GNKVDIKDRK VKAKSIVFHR KKNLQYYDIS AKSNYNFEKP FLWLARKLIG DPNLEFVAMP
     ALAPPEVVMD PALAAQYEQD LQNAQATALP DEDDDL
//