P52301 (RAN_XENLA) Reviewed, UniProtKB/Swiss-Prot
Last modified
November 16, 2011.
Version 81.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: GTP-binding nuclear protein Ran Alternative name(s): GTPase Ran Ras-like protein TC4 Ras-related nuclear protein | ||
| Gene names |
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| Organism | Xenopus laevis (African clawed frog) | ||
| Taxonomic identifier | 8355 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Protein attributes
| Sequence length | 216 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle By similarity. |
| Subcellular location | |
| Sequence similarities | Belongs to the small GTPase superfamily. Ran family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Protein transport Transport |
| Cellular component | Nucleus |
| Ligand | GTP-binding Nucleotide-binding |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | intracellular protein transport Inferred from electronic annotation. Source: InterPro nucleocytoplasmic transportInferred from electronic annotation. Source: InterPro small GTPase mediated signal transductionInferred from electronic annotation. Source: InterPro |
| Cellular component | nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activityInferred from electronic annotation. Source: InterPro protein bindingInferred from physical interaction. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 216 | 216 | GTP-binding nuclear protein Ran | PRO_0000208702 | |||||
Regions | |||||||||
| Nucleotide binding | 17 – 24 | 8 | GTP By similarity | ||||||
| Nucleotide binding | 65 – 69 | 5 | GTP By similarity | ||||||
| Nucleotide binding | 122 – 125 | 4 | GTP By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 199 | 1 | Q → A in AAH41293. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Expression of the Xenopus GTP-binding protein gene Ran during embryogenesis." Onuma Y., Nishihara R., Takahashi S., Tanegashima K., Fukui A., Asashima M. Dev. Genes Evol. 210:325-327(2000) [PubMed: 11180838] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | NIH - Xenopus Gene Collection (XGC) project Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo. |
| [3] | "The GTP-binding protein Ran/TC4 is required for protein import into the nucleus." Moore M.S., Blobel G. Nature 365:661-663(1993) [PubMed: 8413630] [Abstract] Cited for: PROTEIN SEQUENCE OF 40-52 AND 62-71. Tissue: Ovary. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AB030945 mRNA. Translation: BAA89696.1. BC041293 mRNA. Translation: AAH41293.1. |
| RefSeq | NP_001080182.1. NM_001086713.1. NP_001128547.1. NM_001135075.1. |
| UniGene | Xl.55052. Xl.57143. |
3D structure databases | |
| ProteinModelPortal | P52301. |
| SMR | P52301. Positions 8-197. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 100189578. 379874. |
| KEGG | xla:100189578. xla:379874. |
Organism-specific databases | |
| CTD | 176503. 5901. |
| Xenbase | XB-GENE-865870. ran. |
Phylogenomic databases | |
| HOVERGEN | HBG107376. |
Family and domain databases | |
| InterPro | IPR002041. Ran_GTPase. IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. [Graphical view] |
| KO | K07936. |
| Pfam | PF00071. Ras. 1 hit. [Graphical view] |
| PRINTS | PR00627. GTPRANTC4. |
| SMART | SM00176. RAN. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00231. Small_GTP. 1 hit. |
| PROSITE | PS51418. RAN. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | RAN_XENLA | ||||||||
| Accession | Primary (citable) accession number: P52301 Secondary accession number(s): Q7ZYT6, Q9IBE8 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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