Reviewed, UniProtKB/Swiss-Prot P52301 (RAN_XENLA)

Names and origin

Protein names

Recommended name:
GTP-binding nuclear protein Ran

Alternative name(s):
GTPase Ran
Ras-related nuclear protein
Ras-like protein TC4

Gene names

Name:

ran

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	216 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle By similarity.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the small GTPase superfamily. Ran family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Nucleus
Ligand	GTP-binding Nucleotide-binding
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	intracellular protein transport Inferred from electronic annotation. Source: InterPro nucleocytoplasmic transport Inferred from electronic annotation. Source: InterPro signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 216	216	GTP-binding nuclear protein Ran		PRO_0000208702
Regions
	Nucleotide binding	17 – 24	8	GTP By similarity
	Nucleotide binding	65 – 69	5	GTP By similarity
	Nucleotide binding	122 – 125	4	GTP By similarity
Experimental info
	Sequence conflict	199	1	Q → A in AAH41293. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P52301-1 [UniParc]. Last modified August 16, 2004. Version 2. Checksum: D5DB10D65C2AD5A4	FASTA	216	24,398
	10 20 30 40 50 60 MAAQGEPQVQ FKLVLVGDGG TGKTTFVKRH LTGEFEKKYV ATLGVEVHPL VFHTNRGPIK 70 80 90 100 110 120 FNVWDTAGQE KFGGLRDGYY IQAQCAIIMF DVTSRVTYKN VPNWHRDLVR VCENIPIVLC 130 140 150 160 170 180 GNKVDIKDRK VKAKSIVFHR KKNLQYYDIS AKSNYNFEKP FLWLARKLIG DPNLEFVAMP 190 200 210 ALAPPEVVMD PALAAQYEQD LQNAQATALP DEDDDL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression of the Xenopus GTP-binding protein gene Ran during embryogenesis." Onuma Y., Nishihara R., Takahashi S., Tanegashima K., Fukui A., Asashima M. Dev. Genes Evol. 210:325-327(2000) [PubMed: 11180838] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	NIH - Xenopus Gene Collection (XGC) project Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.
[3]	"The GTP-binding protein Ran/TC4 is required for protein import into the nucleus." Moore M.S., Blobel G. Nature 365:661-663(1993) [PubMed: 8413630] [Abstract] Cited for: PROTEIN SEQUENCE OF 40-52 AND 62-71. Tissue: Ovary.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB030945 mRNA. Translation: BAA89696.1. BC041293 mRNA. Translation: AAH41293.1.
RefSeq	NP_001080182.1. NP_001128547.1.
UniGene	Xl.55052 Xl.57143
3D structure databases
SMR	P52301. Positions 8-197.
ModBase	Search...
Genome annotation databases
GeneID	100189578. 379874.
KEGG	xla:100189578. xla:379874.
Organism-specific databases
CTD	100189578. 379874.
Xenbase	XB-FEAT-489467. ran.
Phylogenomic databases
HOVERGEN	HBG107376.
Family and domain databases
InterPro	IPR002041. Ran_GTPase. IPR013753. Ras. IPR005225. Small_GTP_bd. [Graphical view]
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00627. GTPRANTC4.
SMART	SM00176. RAN. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51418. RAN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RAN_XENLA

Accession

Primary (citable) accession number: P52301
Secondary accession number(s): Q7ZYT6, Q9IBE8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	August 16, 2004
Last modified:	March 2, 2010
This is version 71 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)