ID   IMB_XENLA               Reviewed;         260 AA.
AC   P52297;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-1998, sequence version 2.
DT   21-SEP-2011, entry version 51.
DE   RecName: Full=Importin subunit beta;
DE   AltName: Full=Importin-90;
DE   AltName: Full=Karyopherin subunit beta;
DE   AltName: Full=p97;
DE   Flags: Fragments;
GN   Name=kpnb1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae;
OC   Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Egg;
RX   MEDLINE=95353691; PubMed=7627554; DOI=10.1016/S0960-9822(95)00079-0;
RA   Goerlich D., Kostka S., Kraft R., Dingwall C., Laskey R.A.,
RA   Hartmann E., Prehn S.;
RT   "Two different subunits of importin cooperate to recognize nuclear
RT   localization signals and bind them to the nuclear envelope.";
RL   Curr. Biol. 5:383-392(1995).
RN   [2]
RP   PROTEIN SEQUENCE OF 54-69 AND 85-107.
RC   TISSUE=Ovary;
RX   MEDLINE=95183547; PubMed=7878057; DOI=10.1073/pnas.92.5.1769;
RA   Radu A., Blobel G., Moore M.M.;
RT   "Identification of a protein complex that is required for nuclear
RT   protein import and mediates docking of import substrate to distinct
RT   nucleoporins.";
RL   Proc. Natl. Acad. Sci. U.S.A. 92:1769-1773(1995).
CC   -!- FUNCTION: Required for nuclear protein import and mediates docking
CC       of import substrate to distinct nucleoporins.
CC   -!- SUBUNIT: Forms a complex with an importin alpha subunit.
CC   -!- INTERACTION:
CC       Q7ZZY7:Rae1/Gle2; NbExp=4; IntAct=EBI-618940, EBI-618949;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus envelope
CC       (By similarity).
CC   -!- SIMILARITY: Belongs to the importin beta family.
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DR   IntAct; P52297; 2.
DR   MINT; MINT-189354; -.
DR   Xenbase; XB-GENE-994071; kpnb1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.
DR   GO; GO:0005515; F:protein binding; IPI:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR011989; ARM-like.
DR   Gene3D; G3DSA:1.25.10.10; ARM-like; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Direct protein sequencing; Nucleus; Protein transport;
KW   Repeat; Transport.
FT   CHAIN         1   >260       Importin subunit beta.
FT                                /FTId=PRO_0000120761.
FT   CONFLICT     65     65       R -> P (in Ref. 1; AA sequence).
FT   NON_CONS     17     18
FT   NON_CONS     49     50
FT   NON_CONS     69     70
FT   NON_CONS     84     85
FT   NON_CONS    107    108
FT   NON_CONS    126    127
FT   NON_CONS    131    132
FT   NON_CONS    136    137
FT   NON_CONS    141    142
FT   NON_CONS    147    148
FT   NON_CONS    163    164
FT   NON_CONS    183    184
FT   NON_CONS    195    196
FT   NON_CONS    205    206
FT   NON_CONS    210    211
FT   NON_CONS    220    221
FT   NON_CONS    234    235
FT   NON_CONS    240    241
FT   NON_CONS    248    249
FT   NON_TER     260    260
SQ   SEQUENCE   260 AA;  28977 MW;  F66FC8888E27292C CRC64;
     ELVTILEKTV SPDRRXLKFL EQAAVENLPT FVVELSKVLA NPANSQVARK AQYQQRWLAI
     DANARGEIKK ESXLEAIDYI XQDIEEPSNN VRLAATNALL NSLEFTKDLA IEASEAAEQG
     XPPEXTKFYE KKEHIKRYAA VKDPSVVKLL ETTDRPDGHQ NNLDVVMASL LXMFQXTAGS
     GGVQFLLENL GNEXVLAIGG EFXXYKGDYD KGDQENVHPD XVQPRVERIX SFXDKLVEAR
     IHELLTEGKT LATXATKEDV
//