P52297 (IMB_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Importin subunit beta

Alternative name(s):
Importin-90
Karyopherin subunit beta
p97

Gene names

Name:

kpnb1

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	260 AA.
Sequence status	Fragments.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins.
Subunit structure	Forms a complex with an importin alpha subunit.
Subcellular location	Cytoplasm By similarity. Nucleus envelope By similarity.
Sequence similarities	Belongs to the importin beta family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cytoplasm Nucleus
Domain	Repeat
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nuclear envelope Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from physical interaction. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Rae1/Gle2	Q7ZZY7	4	EBI-618940,EBI-618949

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›260	›260	Importin subunit beta		PRO_0000120761
Experimental info
	Sequence conflict	65	1	R → P AA sequence Ref.1
	Non-adjacent residues	17 – 18	2
	Non-adjacent residues	49 – 50	2
	Non-adjacent residues	69 – 70	2
	Non-adjacent residues	84 – 85	2
	Non-adjacent residues	107 – 108	2
	Non-adjacent residues	126 – 127	2
	Non-adjacent residues	131 – 132	2
	Non-adjacent residues	136 – 137	2
	Non-adjacent residues	141 – 142	2
	Non-adjacent residues	147 – 148	2
	Non-adjacent residues	163 – 164	2
	Non-adjacent residues	183 – 184	2
	Non-adjacent residues	195 – 196	2
	Non-adjacent residues	205 – 206	2
	Non-adjacent residues	210 – 211	2
	Non-adjacent residues	220 – 221	2
	Non-adjacent residues	234 – 235	2
	Non-adjacent residues	240 – 241	2
	Non-adjacent residues	248 – 249	2
	Non-terminal residue	260	1

Sequences

	Sequence		Length	Mass (Da)
	P52297 [UniParc]. Last modified December 15, 1998. Version 2. Checksum: F66FC8888E27292C	FASTA	260	28,977
	10 20 30 40 50 60 ELVTILEKTV SPDRRXLKFL EQAAVENLPT FVVELSKVLA NPANSQVARK AQYQQRWLAI 70 80 90 100 110 120 DANARGEIKK ESXLEAIDYI XQDIEEPSNN VRLAATNALL NSLEFTKDLA IEASEAAEQG 130 140 150 160 170 180 XPPEXTKFYE KKEHIKRYAA VKDPSVVKLL ETTDRPDGHQ NNLDVVMASL LXMFQXTAGS 190 200 210 220 230 240 GGVQFLLENL GNEXVLAIGG EFXXYKGDYD KGDQENVHPD XVQPRVERIX SFXDKLVEAR 250 260 IHELLTEGKT LATXATKEDV

References

[1]	"Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope." Goerlich D., Kostka S., Kraft R., Dingwall C., Laskey R.A., Hartmann E., Prehn S. Curr. Biol. 5:383-392(1995) [PubMed: 7627554] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Egg.
[2]	"Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins." Radu A., Blobel G., Moore M.M. Proc. Natl. Acad. Sci. U.S.A. 92:1769-1773(1995) [PubMed: 7878057] [Abstract] Cited for: PROTEIN SEQUENCE OF 54-69 AND 85-107. Tissue: Ovary.
+	Additional computationally mapped references.

Cross-references

3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P52297. 2 interactions.
MINT	MINT-189354.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
Xenbase	XB-GENE-994071. kpnb1.
Family and domain databases
InterPro	IPR011989. ARM-like. [Graphical view]
Gene3D	G3DSA:1.25.10.10. ARM-like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

IMB_XENLA

Accession

Primary (citable) accession number: P52297

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	December 15, 1998
Last modified:	September 21, 2011
This is version 51 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program