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P52291 (PPA1_PICPA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acid phosphatase PHO1

EC=3.1.3.2
Gene names
Name:PHO1
OrganismKomagataella pastoris (Yeast) (Pichia pastoris)
Taxonomic identifier4922 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKomagataella

Protein attributes

Sequence length468 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

A phosphate monoester + H2O = an alcohol + phosphate.

Induction

By phosphate starvation.

Sequence similarities

Belongs to the histidine acid phosphatase family.

Ontologies

Keywords
   Biological processStress response
   DomainSignal
   Molecular functionHydrolase
   PTMGlycoprotein
Gene Ontology (GO)
   Biological_processresponse to stress

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionacid phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 468446Acid phosphatase PHO1
PRO_0000023959

Sites

Active site841Nucleophile By similarity
Active site3461Proton donor By similarity

Amino acid modifications

Glycosylation1631N-linked (GlcNAc...) Potential
Glycosylation1961N-linked (GlcNAc...) Potential
Glycosylation2561N-linked (GlcNAc...) Potential
Glycosylation3211N-linked (GlcNAc...) Potential
Glycosylation3601N-linked (GlcNAc...) Potential
Glycosylation4531N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P52291 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: AE555B8E27718C2C

FASTA46852,691
        10         20         30         40         50         60 
MFSPILSLEI ILALATLQSV FAVELQHVLG VNDRPYPQRT DDQYNILRHL GGLGPYIGYN 

        70         80         90        100        110        120 
GWGIAAESEI ESCTIDQAHL LMRHGERYPS TNVGKQLEAL YQKLLDADVE VPTGPLSFFQ 

       130        140        150        160        170        180 
DYDYFVSDAA WYEQETTKGF YSGLNTAFDF GTTLRERYDH LINTSEEGKK LSVWAGSQER 

       190        200        210        220        230        240 
VVDTAKYFAQ GFMKSNYTDM VEVVALEEEK SQGLNSLTAR ISCPNYNSHI YKDGDFPNDI 

       250        260        270        280        290        300 
AEREADRLNT LSPGFNITAD DIPTIALYCG FELNVRGESS FCDVLSREAL LYTAYLRDLG 

       310        320        330        340        350        360 
WYYNVGNGNP LGKTIGYVYA NATRQLLENT EADPRDYPLY FSFSHDTDLL QVFTSLGLFN 

       370        380        390        400        410        420 
VTDLPLDQIQ FQTSFKSTEI VPMGARLLTE RLLCTVEGEE KYYVRTILND AVFPLSDCSS 

       430        440        450        460 
GPGFSCPLND YVSRLEALNE DSDFAENCGV PKNASYPLEL SFFWDDLS 

« Hide

References

[1]"An inducible acid phosphatase from the yeast Pichia pastoris: characterization of the gene and its product."
Payne W.E., Gannon P.M., Kaiser C.A.
Gene 163:19-26(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U28658 Genomic DNA. Translation: AAA85503.1.
PIRJC4285.

3D structure databases

ProteinModelPortalP52291.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR000560. His_Pase_superF_clade-2.
IPR016274. Histidine_acid_Pase_euk.
[Graphical view]
PfamPF00328. His_Phos_2. 1 hit.
[Graphical view]
PIRSFPIRSF000894. Acid_phosphatase. 1 hit.
PROSITEPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePPA1_PICPA
AccessionPrimary (citable) accession number: P52291
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families