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P52291

- PPA1_PICPA

UniProt

P52291 - PPA1_PICPA

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Protein

Acid phosphatase PHO1

Gene

PHO1

Organism
Komagataella pastoris (Yeast) (Pichia pastoris)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei84 – 841NucleophileBy similarity
Active sitei346 – 3461Proton donorBy similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. response to stress Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Stress response

Names & Taxonomyi

Protein namesi
Recommended name:
Acid phosphatase PHO1 (EC:3.1.3.2)
Gene namesi
Name:PHO1
OrganismiKomagataella pastoris (Yeast) (Pichia pastoris)
Taxonomic identifieri4922 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPhaffomycetaceaeKomagataella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 468446Acid phosphatase PHO1PRO_0000023959Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi196 – 1961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi256 – 2561N-linked (GlcNAc...)Sequence Analysis
Glycosylationi321 – 3211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi360 – 3601N-linked (GlcNAc...)Sequence Analysis
Glycosylationi453 – 4531N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Expressioni

Inductioni

By phosphate starvation.

Structurei

3D structure databases

ProteinModelPortaliP52291.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidine acid phosphatase family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
InterProiIPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
IPR016274. Histidine_acid_Pase_euk.
[Graphical view]
PfamiPF00328. His_Phos_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000894. Acid_phosphatase. 1 hit.
SUPFAMiSSF53254. SSF53254. 1 hit.
PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52291 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFSPILSLEI ILALATLQSV FAVELQHVLG VNDRPYPQRT DDQYNILRHL
60 70 80 90 100
GGLGPYIGYN GWGIAAESEI ESCTIDQAHL LMRHGERYPS TNVGKQLEAL
110 120 130 140 150
YQKLLDADVE VPTGPLSFFQ DYDYFVSDAA WYEQETTKGF YSGLNTAFDF
160 170 180 190 200
GTTLRERYDH LINTSEEGKK LSVWAGSQER VVDTAKYFAQ GFMKSNYTDM
210 220 230 240 250
VEVVALEEEK SQGLNSLTAR ISCPNYNSHI YKDGDFPNDI AEREADRLNT
260 270 280 290 300
LSPGFNITAD DIPTIALYCG FELNVRGESS FCDVLSREAL LYTAYLRDLG
310 320 330 340 350
WYYNVGNGNP LGKTIGYVYA NATRQLLENT EADPRDYPLY FSFSHDTDLL
360 370 380 390 400
QVFTSLGLFN VTDLPLDQIQ FQTSFKSTEI VPMGARLLTE RLLCTVEGEE
410 420 430 440 450
KYYVRTILND AVFPLSDCSS GPGFSCPLND YVSRLEALNE DSDFAENCGV
460
PKNASYPLEL SFFWDDLS
Length:468
Mass (Da):52,691
Last modified:October 1, 1996 - v1
Checksum:iAE555B8E27718C2C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U28658 Genomic DNA. Translation: AAA85503.1.
PIRiJC4285.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U28658 Genomic DNA. Translation: AAA85503.1 .
PIRi JC4285.

3D structure databases

ProteinModelPortali P52291.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.1240. 1 hit.
InterProi IPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
IPR016274. Histidine_acid_Pase_euk.
[Graphical view ]
Pfami PF00328. His_Phos_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000894. Acid_phosphatase. 1 hit.
SUPFAMi SSF53254. SSF53254. 1 hit.
PROSITEi PS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "An inducible acid phosphatase from the yeast Pichia pastoris: characterization of the gene and its product."
    Payne W.E., Gannon P.M., Kaiser C.A.
    Gene 163:19-26(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiPPA1_PICPA
AccessioniPrimary (citable) accession number: P52291
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3