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P52291

- PPA1_PICPA

UniProt

P52291 - PPA1_PICPA

Protein

Acid phosphatase PHO1

Gene

PHO1

Organism
Komagataella pastoris (Yeast) (Pichia pastoris)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    A phosphate monoester + H2O = an alcohol + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei84 – 841NucleophileBy similarity
    Active sitei346 – 3461Proton donorBy similarity

    GO - Molecular functioni

    1. acid phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. response to stress Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Stress response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acid phosphatase PHO1 (EC:3.1.3.2)
    Gene namesi
    Name:PHO1
    OrganismiKomagataella pastoris (Yeast) (Pichia pastoris)
    Taxonomic identifieri4922 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKomagataella

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 468446Acid phosphatase PHO1PRO_0000023959Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi196 – 1961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi256 – 2561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi321 – 3211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi360 – 3601N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi453 – 4531N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Expressioni

    Inductioni

    By phosphate starvation.

    Structurei

    3D structure databases

    ProteinModelPortaliP52291.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidine acid phosphatase family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.40.50.1240. 1 hit.
    InterProiIPR000560. His_Pase_superF_clade-2.
    IPR029033. His_PPase_superfam.
    IPR016274. Histidine_acid_Pase_euk.
    [Graphical view]
    PfamiPF00328. His_Phos_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000894. Acid_phosphatase. 1 hit.
    SUPFAMiSSF53254. SSF53254. 1 hit.
    PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
    PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P52291-1 [UniParc]FASTAAdd to Basket

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    MFSPILSLEI ILALATLQSV FAVELQHVLG VNDRPYPQRT DDQYNILRHL    50
    GGLGPYIGYN GWGIAAESEI ESCTIDQAHL LMRHGERYPS TNVGKQLEAL 100
    YQKLLDADVE VPTGPLSFFQ DYDYFVSDAA WYEQETTKGF YSGLNTAFDF 150
    GTTLRERYDH LINTSEEGKK LSVWAGSQER VVDTAKYFAQ GFMKSNYTDM 200
    VEVVALEEEK SQGLNSLTAR ISCPNYNSHI YKDGDFPNDI AEREADRLNT 250
    LSPGFNITAD DIPTIALYCG FELNVRGESS FCDVLSREAL LYTAYLRDLG 300
    WYYNVGNGNP LGKTIGYVYA NATRQLLENT EADPRDYPLY FSFSHDTDLL 350
    QVFTSLGLFN VTDLPLDQIQ FQTSFKSTEI VPMGARLLTE RLLCTVEGEE 400
    KYYVRTILND AVFPLSDCSS GPGFSCPLND YVSRLEALNE DSDFAENCGV 450
    PKNASYPLEL SFFWDDLS 468
    Length:468
    Mass (Da):52,691
    Last modified:October 1, 1996 - v1
    Checksum:iAE555B8E27718C2C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U28658 Genomic DNA. Translation: AAA85503.1.
    PIRiJC4285.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U28658 Genomic DNA. Translation: AAA85503.1 .
    PIRi JC4285.

    3D structure databases

    ProteinModelPortali P52291.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.50.1240. 1 hit.
    InterProi IPR000560. His_Pase_superF_clade-2.
    IPR029033. His_PPase_superfam.
    IPR016274. Histidine_acid_Pase_euk.
    [Graphical view ]
    Pfami PF00328. His_Phos_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000894. Acid_phosphatase. 1 hit.
    SUPFAMi SSF53254. SSF53254. 1 hit.
    PROSITEi PS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
    PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "An inducible acid phosphatase from the yeast Pichia pastoris: characterization of the gene and its product."
      Payne W.E., Gannon P.M., Kaiser C.A.
      Gene 163:19-26(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiPPA1_PICPA
    AccessioniPrimary (citable) accession number: P52291
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3