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P52291

- PPA1_PICPA

UniProt

P52291 - PPA1_PICPA

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Protein

Acid phosphatase PHO1

Gene
PHO1
Organism
Komagataella pastoris (Yeast) (Pichia pastoris)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei84 – 841Nucleophile By similarity
Active sitei346 – 3461Proton donor By similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. response to stress Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Stress response

Names & Taxonomyi

Protein namesi
Recommended name:
Acid phosphatase PHO1 (EC:3.1.3.2)
Gene namesi
Name:PHO1
OrganismiKomagataella pastoris (Yeast) (Pichia pastoris)
Taxonomic identifieri4922 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKomagataella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed predictionAdd
BLAST
Chaini23 – 468446Acid phosphatase PHO1PRO_0000023959Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi163 – 1631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi196 – 1961N-linked (GlcNAc...) Reviewed prediction
Glycosylationi256 – 2561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi321 – 3211N-linked (GlcNAc...) Reviewed prediction
Glycosylationi360 – 3601N-linked (GlcNAc...) Reviewed prediction
Glycosylationi453 – 4531N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Expressioni

Inductioni

By phosphate starvation.

Structurei

3D structure databases

ProteinModelPortaliP52291.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
InterProiIPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
IPR016274. Histidine_acid_Pase_euk.
[Graphical view]
PfamiPF00328. His_Phos_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000894. Acid_phosphatase. 1 hit.
SUPFAMiSSF53254. SSF53254. 1 hit.
PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52291-1 [UniParc]FASTAAdd to Basket

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MFSPILSLEI ILALATLQSV FAVELQHVLG VNDRPYPQRT DDQYNILRHL    50
GGLGPYIGYN GWGIAAESEI ESCTIDQAHL LMRHGERYPS TNVGKQLEAL 100
YQKLLDADVE VPTGPLSFFQ DYDYFVSDAA WYEQETTKGF YSGLNTAFDF 150
GTTLRERYDH LINTSEEGKK LSVWAGSQER VVDTAKYFAQ GFMKSNYTDM 200
VEVVALEEEK SQGLNSLTAR ISCPNYNSHI YKDGDFPNDI AEREADRLNT 250
LSPGFNITAD DIPTIALYCG FELNVRGESS FCDVLSREAL LYTAYLRDLG 300
WYYNVGNGNP LGKTIGYVYA NATRQLLENT EADPRDYPLY FSFSHDTDLL 350
QVFTSLGLFN VTDLPLDQIQ FQTSFKSTEI VPMGARLLTE RLLCTVEGEE 400
KYYVRTILND AVFPLSDCSS GPGFSCPLND YVSRLEALNE DSDFAENCGV 450
PKNASYPLEL SFFWDDLS 468
Length:468
Mass (Da):52,691
Last modified:October 1, 1996 - v1
Checksum:iAE555B8E27718C2C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U28658 Genomic DNA. Translation: AAA85503.1.
PIRiJC4285.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U28658 Genomic DNA. Translation: AAA85503.1 .
PIRi JC4285.

3D structure databases

ProteinModelPortali P52291.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.1240. 1 hit.
InterProi IPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
IPR016274. Histidine_acid_Pase_euk.
[Graphical view ]
Pfami PF00328. His_Phos_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000894. Acid_phosphatase. 1 hit.
SUPFAMi SSF53254. SSF53254. 1 hit.
PROSITEi PS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "An inducible acid phosphatase from the yeast Pichia pastoris: characterization of the gene and its product."
    Payne W.E., Gannon P.M., Kaiser C.A.
    Gene 163:19-26(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiPPA1_PICPA
AccessioniPrimary (citable) accession number: P52291
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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