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P52290

- PPAD_YEAST

UniProt

P52290 - PPAD_YEAST

Protein

Probable acid phosphatase DIA3

Gene

DIA3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    A phosphate monoester + H2O = an alcohol + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei76 – 761NucleophileBy similarity
    Active sitei339 – 3391Proton donorBy similarity

    GO - Molecular functioni

    1. acid phosphatase activity Source: SGD

    GO - Biological processi

    1. dephosphorylation Source: GOC
    2. invasive growth in response to glucose limitation Source: SGD
    3. pseudohyphal growth Source: SGD

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29451-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable acid phosphatase DIA3 (EC:3.1.3.2)
    Alternative name(s):
    Digs into agar protein 3
    Gene namesi
    Name:DIA3
    Ordered Locus Names:YDL024C
    ORF Names:D2815
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IV

    Organism-specific databases

    CYGDiYDL024c.
    SGDiS000002182. DIA3.

    Subcellular locationi

    GO - Cellular componenti

    1. fungal-type cell wall Source: SGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020By similarityAdd
    BLAST
    Chaini21 – 468448Probable acid phosphatase DIA3PRO_0000023958Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi193 – 1931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi238 – 2381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi251 – 2511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi357 – 3571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi391 – 3911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi457 – 4571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi462 – 4621N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Expressioni

    Gene expression databases

    GenevestigatoriP52290.

    Interactioni

    Protein-protein interaction databases

    BioGridi32031. 11 interactions.
    DIPiDIP-5014N.
    IntActiP52290. 1 interaction.
    MINTiMINT-475083.
    STRINGi4932.YDL024C.

    Structurei

    3D structure databases

    ProteinModelPortaliP52290.
    SMRiP52290. Positions 35-467.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidine acid phosphatase family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG265642.
    GeneTreeiENSGT00510000050349.
    HOGENOMiHOG000189191.
    KOiK01078.
    OMAiNICDIFS.
    OrthoDBiEOG7TQV9N.

    Family and domain databases

    Gene3Di3.40.50.1240. 1 hit.
    InterProiIPR000560. His_Pase_superF_clade-2.
    IPR029033. His_PPase_superfam.
    IPR016274. Histidine_acid_Pase_euk.
    [Graphical view]
    PfamiPF00328. His_Phos_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000894. Acid_phosphatase. 1 hit.
    SUPFAMiSSF53254. SSF53254. 1 hit.
    PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
    PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P52290-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVKPVIFAIC LGVLLSKALS IPLRSFADIE LIGSQKSLFP FLGGSAPYFS    50
    FPANYGIPTD IPEGCRLTQV QMIGRHGERY PTRSEAKDIF EVWYKISNYT 100
    GKYEGSLSFL NNGYEFFIPD ESLLEMETTL QNSIDVLNPY TGEMNAKRHA 150
    REFLAKYGKL MENCTNFPIF TTNSKRIYDT AQYFAEALGD GFNISLQTLS 200
    ENSSSGANTL AAKSSCPNWN SNANNDILMS YSRDYLENIS DRLNDENKGL 250
    NLSRKDAAAL FSWCAFELNA KGYSNICDIF SAAELIHYSY ETDLTSFYQN 300
    GPGYKLIKSI GANLFNATVK LIRQSAHLDQ KVWLSFTHDT DILNYLTTAG 350
    LIDDTRNLTT NHVPFRDHSY HRSWYIPQGA RVYTEKFQCS NDSYVRYVVN 400
    DAVVPIESCS SGPGFSCEEG TFYEYAKDRL RGVSFYEDCD VSKVSKEKEL 450
    TFYWDWNTTR YNASLVNQ 468
    Length:468
    Mass (Da):53,076
    Last modified:October 1, 1996 - v1
    Checksum:i1F07FF374DDF162C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z48432 Genomic DNA. Translation: CAA88335.1.
    Z74072 Genomic DNA. Translation: CAA98583.1.
    BK006938 Genomic DNA. Translation: DAA11827.1.
    PIRiS52495.
    RefSeqiNP_010260.1. NM_001180083.1.

    Genome annotation databases

    EnsemblFungiiYDL024C; YDL024C; YDL024C.
    GeneIDi851537.
    KEGGisce:YDL024C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z48432 Genomic DNA. Translation: CAA88335.1 .
    Z74072 Genomic DNA. Translation: CAA98583.1 .
    BK006938 Genomic DNA. Translation: DAA11827.1 .
    PIRi S52495.
    RefSeqi NP_010260.1. NM_001180083.1.

    3D structure databases

    ProteinModelPortali P52290.
    SMRi P52290. Positions 35-467.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32031. 11 interactions.
    DIPi DIP-5014N.
    IntActi P52290. 1 interaction.
    MINTi MINT-475083.
    STRINGi 4932.YDL024C.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YDL024C ; YDL024C ; YDL024C .
    GeneIDi 851537.
    KEGGi sce:YDL024C.

    Organism-specific databases

    CYGDi YDL024c.
    SGDi S000002182. DIA3.

    Phylogenomic databases

    eggNOGi NOG265642.
    GeneTreei ENSGT00510000050349.
    HOGENOMi HOG000189191.
    KOi K01078.
    OMAi NICDIFS.
    OrthoDBi EOG7TQV9N.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29451-MONOMER.

    Miscellaneous databases

    NextBioi 968938.

    Gene expression databases

    Genevestigatori P52290.

    Family and domain databases

    Gene3Di 3.40.50.1240. 1 hit.
    InterProi IPR000560. His_Pase_superF_clade-2.
    IPR029033. His_PPase_superfam.
    IPR016274. Histidine_acid_Pase_euk.
    [Graphical view ]
    Pfami PF00328. His_Phos_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000894. Acid_phosphatase. 1 hit.
    SUPFAMi SSF53254. SSF53254. 1 hit.
    PROSITEi PS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
    PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
      Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
      , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
      Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.

    Entry informationi

    Entry nameiPPAD_YEAST
    AccessioniPrimary (citable) accession number: P52290
    Secondary accession number(s): D6VRW7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome IV
      Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

    External Data

    Dasty 3