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P52289

- PPA5_KLULA

UniProt

P52289 - PPA5_KLULA

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Protein

Repressible acid phosphatase

Gene
PHO5, KLLA0B00286g
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei77 – 771Nucleophile By similarity
Active sitei340 – 3401Proton donor By similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Repressible acid phosphatase (EC:3.1.3.2)
Gene namesi
Name:PHO5
Ordered Locus Names:KLLA0B00286g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
ProteomesiUP000000598: Chromosome B

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616 Reviewed predictionAdd
BLAST
Chaini17 – 469453Repressible acid phosphatasePRO_0000023955Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi23 – 231N-linked (GlcNAc...) Reviewed prediction
Glycosylationi31 – 311N-linked (GlcNAc...) Reviewed prediction
Glycosylationi129 – 1291N-linked (GlcNAc...) Reviewed prediction
Glycosylationi201 – 2011N-linked (GlcNAc...) Reviewed prediction
Glycosylationi229 – 2291N-linked (GlcNAc...) Reviewed prediction
Glycosylationi250 – 2501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi317 – 3171N-linked (GlcNAc...) Reviewed prediction
Glycosylationi392 – 3921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi447 – 4471N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Glycosylated during secretion across the membrane.

Keywords - PTMi

Glycoprotein

Expressioni

Inductioni

Repressed by inorganic phosphate By similarity.

Interactioni

Protein-protein interaction databases

STRINGi28985.P52289.

Structurei

3D structure databases

ProteinModelPortaliP52289.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG265642.
HOGENOMiHOG000189191.
OMAiDESNVEY.
OrthoDBiEOG7TQV9N.

Family and domain databases

Gene3Di3.40.50.1240. 3 hits.
InterProiIPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
IPR016274. Histidine_acid_Pase_euk.
[Graphical view]
PfamiPF00328. His_Phos_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000894. Acid_phosphatase. 1 hit.
SUPFAMiSSF53254. SSF53254. 1 hit.
PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52289-1 [UniParc]FASTAAdd to Basket

« Hide

MLSILLSLLS LSGTHAAPIS KDNGTVCYAL NSSTTDESIF PLLNGQGPHY    50
DYPQSFGIPV EVPDQCTVEH VQMLARHGER YPTASKGKLM IALWDKLKEF 100
QGQYNGPMEV FNDYEFFVSN TKYFDQLTNS TDVDPSNPYA GAKTAQHLGK 150
YIAYNYGDLF SDSNPVFTSS SGRVHQTAKY VVSSLEEELD IQLDLQIIQE 200
NETSGANSLT PADSCMTYNG DLGDEYFENA TLPYLTDIKN RWMKKNSNLN 250
LTLEHDDIEL LVDWCAFETN VKGSSAVCDL FERNDLVAYS YYANVNNFYR 300
RGAGNPMSNP IGSVLVNASY NLLTQADELD NKVWLSFSHD TDIQQFISAL 350
GLIDNGVTEY SLDQVDFQNI QQLSWVTPMG GRIFTEKLKC GNASYVRYII 400
NDVIIPVPGC TSGPGFSCPI EDFDDYITNR LNGIDYVSSC EVQQVSNTTE 450
LTFYWDYNEV EYNGPVSNK 469
Length:469
Mass (Da):52,505
Last modified:September 27, 2004 - v2
Checksum:iC6169701E485691A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71S → G in CAA83964. 1 Publication
Sequence conflicti32 – 321S → N in CAA83964. 1 Publication
Sequence conflicti41 – 411P → S in CAA83964. 1 Publication
Sequence conflicti106 – 1083GPM → DPL in CAA83964. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z33995 Genomic DNA. Translation: CAA83964.1.
CR382122 Genomic DNA. Translation: CAH01935.1.
RefSeqiXP_451542.1. XM_451542.1.

Genome annotation databases

GeneIDi2896996.
KEGGikla:KLLA0B00286g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z33995 Genomic DNA. Translation: CAA83964.1 .
CR382122 Genomic DNA. Translation: CAH01935.1 .
RefSeqi XP_451542.1. XM_451542.1.

3D structure databases

ProteinModelPortali P52289.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 28985.P52289.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2896996.
KEGGi kla:KLLA0B00286g.

Phylogenomic databases

eggNOGi NOG265642.
HOGENOMi HOG000189191.
OMAi DESNVEY.
OrthoDBi EOG7TQV9N.

Family and domain databases

Gene3Di 3.40.50.1240. 3 hits.
InterProi IPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
IPR016274. Histidine_acid_Pase_euk.
[Graphical view ]
Pfami PF00328. His_Phos_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000894. Acid_phosphatase. 1 hit.
SUPFAMi SSF53254. SSF53254. 1 hit.
PROSITEi PS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Ferminan E.
    Thesis (1995), University of Salamanca, Spain
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 76492 / CBS 2359/152 / CLIB 210.
  2. "Genome evolution in yeasts."
    Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
    , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
    Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37.

Entry informationi

Entry nameiPPA5_KLULA
AccessioniPrimary (citable) accession number: P52289
Secondary accession number(s): Q6CWZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: September 27, 2004
Last modified: June 11, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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