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P52289 (PPA5_KLULA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Repressible acid phosphatase

EC=3.1.3.2
Gene names
Name:PHO5
Ordered Locus Names:KLLA0B00286g
OrganismKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome]
Taxonomic identifier284590 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces

Protein attributes

Sequence length469 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

A phosphate monoester + H2O = an alcohol + phosphate.

Subcellular location

Secreted.

Induction

Repressed by inorganic phosphate By similarity.

Post-translational modification

Glycosylated during secretion across the membrane.

Sequence similarities

Belongs to the histidine acid phosphatase family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionHydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionacid phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Potential
Chain17 – 469453Repressible acid phosphatase
PRO_0000023955

Sites

Active site771Nucleophile By similarity
Active site3401Proton donor By similarity

Amino acid modifications

Glycosylation231N-linked (GlcNAc...) Potential
Glycosylation311N-linked (GlcNAc...) Potential
Glycosylation1291N-linked (GlcNAc...) Potential
Glycosylation2011N-linked (GlcNAc...) Potential
Glycosylation2291N-linked (GlcNAc...) Potential
Glycosylation2501N-linked (GlcNAc...) Potential
Glycosylation3171N-linked (GlcNAc...) Potential
Glycosylation3921N-linked (GlcNAc...) Potential
Glycosylation4471N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict71S → G in CAA83964. Ref.1
Sequence conflict321S → N in CAA83964. Ref.1
Sequence conflict411P → S in CAA83964. Ref.1
Sequence conflict106 – 1083GPM → DPL in CAA83964. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P52289 [UniParc].

Last modified September 27, 2004. Version 2.
Checksum: C6169701E485691A

FASTA46952,505
        10         20         30         40         50         60 
MLSILLSLLS LSGTHAAPIS KDNGTVCYAL NSSTTDESIF PLLNGQGPHY DYPQSFGIPV 

        70         80         90        100        110        120 
EVPDQCTVEH VQMLARHGER YPTASKGKLM IALWDKLKEF QGQYNGPMEV FNDYEFFVSN 

       130        140        150        160        170        180 
TKYFDQLTNS TDVDPSNPYA GAKTAQHLGK YIAYNYGDLF SDSNPVFTSS SGRVHQTAKY 

       190        200        210        220        230        240 
VVSSLEEELD IQLDLQIIQE NETSGANSLT PADSCMTYNG DLGDEYFENA TLPYLTDIKN 

       250        260        270        280        290        300 
RWMKKNSNLN LTLEHDDIEL LVDWCAFETN VKGSSAVCDL FERNDLVAYS YYANVNNFYR 

       310        320        330        340        350        360 
RGAGNPMSNP IGSVLVNASY NLLTQADELD NKVWLSFSHD TDIQQFISAL GLIDNGVTEY 

       370        380        390        400        410        420 
SLDQVDFQNI QQLSWVTPMG GRIFTEKLKC GNASYVRYII NDVIIPVPGC TSGPGFSCPI 

       430        440        450        460 
EDFDDYITNR LNGIDYVSSC EVQQVSNTTE LTFYWDYNEV EYNGPVSNK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z33995 Genomic DNA. Translation: CAA83964.1.
CR382122 Genomic DNA. Translation: CAH01935.1.
RefSeqXP_451542.1. XM_451542.1.

3D structure databases

ProteinModelPortalP52289.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING28985.P52289.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2896996.
KEGGkla:KLLA0B00286g.

Phylogenomic databases

eggNOGNOG265642.
HOGENOMHOG000189191.
OMADESNVEY.
OrthoDBEOG7TQV9N.

Family and domain databases

InterProIPR000560. His_Pase_superF_clade-2.
IPR016274. Histidine_acid_Pase_euk.
[Graphical view]
PfamPF00328. His_Phos_2. 1 hit.
[Graphical view]
PIRSFPIRSF000894. Acid_phosphatase. 1 hit.
PROSITEPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePPA5_KLULA
AccessionPrimary (citable) accession number: P52289
Secondary accession number(s): Q6CWZ7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: September 27, 2004
Last modified: April 16, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families