Repressible acid phosphatase precursor - Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast)

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P52289 (PPA5_KLULA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 78. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Repressible acid phosphatase
EC=3.1.3.2

Gene names

Name:	PHO5
Ordered Locus Names:	KLLA0B00286g

Organism

Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome]

Taxonomic identifier

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces ›

Protein attributes

Sequence length	469 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	A phosphate monoester + H₂O = an alcohol + phosphate.
Subcellular location	Secreted.
Induction	Repressed by inorganic phosphate By similarity.
Post-translational modification	Glycosylated during secretion across the membrane.
Sequence similarities	Belongs to the histidine acid phosphatase family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Hydrolase
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: GOC
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	acid phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

16

Potential

Chain

453

Repressible acid phosphatase

PRO_0000023955

Sites

Active site

1

Nucleophile By similarity

Active site

1

Proton donor By similarity

Amino acid modifications

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict

1

S → G in CAA83964. Ref.1

Sequence conflict

1

S → N in CAA83964. Ref.1

Sequence conflict

1

P → S in CAA83964. Ref.1

Sequence conflict

3

GPM → DPL in CAA83964. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

P52289 [UniParc].

Last modified September 27, 2004. Version 2.
Checksum: C6169701E485691A
Show »

469

52,505

        10         20         30         40         50         60 
MLSILLSLLS LSGTHAAPIS KDNGTVCYAL NSSTTDESIF PLLNGQGPHY DYPQSFGIPV 

        70         80         90        100        110        120 
EVPDQCTVEH VQMLARHGER YPTASKGKLM IALWDKLKEF QGQYNGPMEV FNDYEFFVSN 

       130        140        150        160        170        180 
TKYFDQLTNS TDVDPSNPYA GAKTAQHLGK YIAYNYGDLF SDSNPVFTSS SGRVHQTAKY 

       190        200        210        220        230        240 
VVSSLEEELD IQLDLQIIQE NETSGANSLT PADSCMTYNG DLGDEYFENA TLPYLTDIKN 

       250        260        270        280        290        300 
RWMKKNSNLN LTLEHDDIEL LVDWCAFETN VKGSSAVCDL FERNDLVAYS YYANVNNFYR 

       310        320        330        340        350        360 
RGAGNPMSNP IGSVLVNASY NLLTQADELD NKVWLSFSHD TDIQQFISAL GLIDNGVTEY 

       370        380        390        400        410        420 
SLDQVDFQNI QQLSWVTPMG GRIFTEKLKC GNASYVRYII NDVIIPVPGC TSGPGFSCPI 

       430        440        450        460 
EDFDDYITNR LNGIDYVSSC EVQQVSNTTE LTFYWDYNEV EYNGPVSNK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Ferminan E. Thesis (1995), University of Salamanca, Spain Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 76492 / CBS 2359/152 / CLIB 210.
[2]	"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. Souciet J.-L. Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z33995 Genomic DNA. Translation: CAA83964.1. CR382122 Genomic DNA. Translation: CAH01935.1.
RefSeq	XP_451542.1. XM_451542.1.
3D structure databases
ProteinModelPortal	P52289.
ModBase	Search...
Protein-protein interaction databases
STRING	28985.P52289.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2896996.
KEGG	kla:KLLA0B00286g.
Phylogenomic databases
eggNOG	NOG265642.
HOGENOM	HOG000189191.
OMA	DESNVEY.
OrthoDB	EOG42Z7ZR.
Family and domain databases
InterPro	IPR000560. His_Pase_superF_clade-2. IPR016274. Histidine_acid_Pase_euk. [Graphical view]
Pfam	PF00328. His_Phos_2. 1 hit. [Graphical view]
PIRSF	PIRSF000894. Acid_phosphatase. 1 hit.
PROSITE	PS00616. HIS_ACID_PHOSPHAT_1. 1 hit. PS00778. HIS_ACID_PHOSPHAT_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PPA5_KLULA

Accession

Primary (citable) accession number: P52289
Secondary accession number(s): Q6CWZ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	September 27, 2004
Last modified:	May 1, 2013
This is version 78 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents