Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P52289

- PPA5_KLULA

UniProt

P52289 - PPA5_KLULA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Repressible acid phosphatase

Gene

PHO5

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei77 – 771NucleophileBy similarity
Active sitei340 – 3401Proton donorBy similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Repressible acid phosphatase (EC:3.1.3.2)
Gene namesi
Name:PHO5
Ordered Locus Names:KLLA0B00286g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
ProteomesiUP000000598: Chromosome B

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence AnalysisAdd
BLAST
Chaini17 – 469453Repressible acid phosphatasePRO_0000023955Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi23 – 231N-linked (GlcNAc...)Sequence Analysis
Glycosylationi31 – 311N-linked (GlcNAc...)Sequence Analysis
Glycosylationi129 – 1291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi201 – 2011N-linked (GlcNAc...)Sequence Analysis
Glycosylationi229 – 2291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi250 – 2501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi317 – 3171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi392 – 3921N-linked (GlcNAc...)Sequence Analysis
Glycosylationi447 – 4471N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Glycosylated during secretion across the membrane.

Keywords - PTMi

Glycoprotein

Expressioni

Inductioni

Repressed by inorganic phosphate.By similarity

Interactioni

Protein-protein interaction databases

STRINGi28985.P52289.

Structurei

3D structure databases

ProteinModelPortaliP52289.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidine acid phosphatase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG265642.
HOGENOMiHOG000189191.
InParanoidiP52289.
OMAiDESNVEY.
OrthoDBiEOG7TQV9N.

Family and domain databases

Gene3Di3.40.50.1240. 3 hits.
InterProiIPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
IPR016274. Histidine_acid_Pase_euk.
[Graphical view]
PfamiPF00328. His_Phos_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000894. Acid_phosphatase. 1 hit.
SUPFAMiSSF53254. SSF53254. 1 hit.
PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52289-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSILLSLLS LSGTHAAPIS KDNGTVCYAL NSSTTDESIF PLLNGQGPHY
60 70 80 90 100
DYPQSFGIPV EVPDQCTVEH VQMLARHGER YPTASKGKLM IALWDKLKEF
110 120 130 140 150
QGQYNGPMEV FNDYEFFVSN TKYFDQLTNS TDVDPSNPYA GAKTAQHLGK
160 170 180 190 200
YIAYNYGDLF SDSNPVFTSS SGRVHQTAKY VVSSLEEELD IQLDLQIIQE
210 220 230 240 250
NETSGANSLT PADSCMTYNG DLGDEYFENA TLPYLTDIKN RWMKKNSNLN
260 270 280 290 300
LTLEHDDIEL LVDWCAFETN VKGSSAVCDL FERNDLVAYS YYANVNNFYR
310 320 330 340 350
RGAGNPMSNP IGSVLVNASY NLLTQADELD NKVWLSFSHD TDIQQFISAL
360 370 380 390 400
GLIDNGVTEY SLDQVDFQNI QQLSWVTPMG GRIFTEKLKC GNASYVRYII
410 420 430 440 450
NDVIIPVPGC TSGPGFSCPI EDFDDYITNR LNGIDYVSSC EVQQVSNTTE
460
LTFYWDYNEV EYNGPVSNK
Length:469
Mass (Da):52,505
Last modified:September 27, 2004 - v2
Checksum:iC6169701E485691A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71S → G in CAA83964. 1 PublicationCurated
Sequence conflicti32 – 321S → N in CAA83964. 1 PublicationCurated
Sequence conflicti41 – 411P → S in CAA83964. 1 PublicationCurated
Sequence conflicti106 – 1083GPM → DPL in CAA83964. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z33995 Genomic DNA. Translation: CAA83964.1.
CR382122 Genomic DNA. Translation: CAH01935.1.
RefSeqiXP_451542.1. XM_451542.1.

Genome annotation databases

GeneIDi2896996.
KEGGikla:KLLA0B00286g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z33995 Genomic DNA. Translation: CAA83964.1 .
CR382122 Genomic DNA. Translation: CAH01935.1 .
RefSeqi XP_451542.1. XM_451542.1.

3D structure databases

ProteinModelPortali P52289.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 28985.P52289.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2896996.
KEGGi kla:KLLA0B00286g.

Phylogenomic databases

eggNOGi NOG265642.
HOGENOMi HOG000189191.
InParanoidi P52289.
OMAi DESNVEY.
OrthoDBi EOG7TQV9N.

Family and domain databases

Gene3Di 3.40.50.1240. 3 hits.
InterProi IPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
IPR016274. Histidine_acid_Pase_euk.
[Graphical view ]
Pfami PF00328. His_Phos_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000894. Acid_phosphatase. 1 hit.
SUPFAMi SSF53254. SSF53254. 1 hit.
PROSITEi PS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Ferminan E.
    Thesis (1995), University of Salamanca, Spain
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 76492 / CBS 2359/152 / CLIB 210.
  2. "Genome evolution in yeasts."
    Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
    , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
    Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37.

Entry informationi

Entry nameiPPA5_KLULA
AccessioniPrimary (citable) accession number: P52289
Secondary accession number(s): Q6CWZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: September 27, 2004
Last modified: October 29, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3