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P52284 (MTR1_PBCVX) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Modification methylase CviRI

Short name=M.CviRI
EC=2.1.1.72
Alternative name(s):
Adenine-specific methyltransferase CviRI
Gene names
Name:CVIRIM
OrganismParamecium bursaria Chlorella virus XZ-6E (PBCV-XZ-6E)
Taxonomic identifier36360 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stagePhycodnaviridaeChlorovirusunclassified Chlorovirus
Virus hostChlorella [TaxID: 114049]

Protein attributes

Sequence length379 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This methylase recognizes the double-stranded sequence TGCA, causes specific methylation on A-4 on both strands, and protects the DNA from cleavage by the CviRI endonuclease.

Catalytic activity

S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

Sequence similarities

Belongs to the N(4)/N(6)-methyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 379379Modification methylase CviRI
PRO_0000087949

Sequences

Sequence LengthMass (Da)Tools
P52284 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 22758935BB702BFA

FASTA37942,815
        10         20         30         40         50         60 
MKLFEDKSVE FHKRLSKKER SDGGVFFTPK DIRDIVFEEL GDFEPTNILE PTCGTGEFIS 

        70         80         90        100        110        120 
DCRKVYKNSR IIGVEIDPRS AELARDGSKN EIIVHDFMTW DTDEKFDLII GNPPYFTRPT 

       130        140        150        160        170        180 
GFKHDPSVVK CRSNICIEVL HKCITRHLAD NGMLAMVLPV SILNSKFYTP TIDLITDTMD 

       190        200        210        220        230        240 
VVSARAIKKN NFMGTNVRVM VFIIRKRTPG FVSKYTFKTS LGKVIINPDG ERLGSIVSGK 

       250        260        270        280        290        300 
KTIGSLNVNI SFGVTLASVK EYFVDKSCSG SFPLICYNNI AKKGDLLFVS DKYSKKRFNG 

       310        320        330        340        350        360 
RAILIPRGYA HGDYSFNFID YTNDYFIIEN HVIAITGEDC VLDIIAKSFA DHRTREFCRL 

       370 
LCSSGDISKD YVKEIPVFG 

« Hide

References

[1]"Molecular cloning and characterization of the gene encoding the adenine methyltransferase M.CviRI from Chlorella virus XZ-6E."
Stefan G., Xia Y., van Etten J.L.
Nucleic Acids Res. 19:307-311(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M38173 Genomic DNA. Translation: AAA42900.1.

3D structure databases

ProteinModelPortalP52284.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

REBASE3355. M.CviRI.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR002052. DNA_methylase_N6_adenine_CS.
IPR002296. N12N6_MeTrfase.
[Graphical view]
PRINTSPR00507. N12N6MTFRASE.
PROSITEPS00092. N6_MTASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTR1_PBCVX
AccessionPrimary (citable) accession number: P52284
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Restriction enzymes and methylases

Classification of restriction enzymes and methylases and list of entries