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P52284

- MTR1_PBCVX

UniProt

P52284 - MTR1_PBCVX

Protein

Modification methylase CviRI

Gene

CVIRIM

Organism
Paramecium bursaria Chlorella virus XZ-6E (PBCV-XZ-6E)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    This methylase recognizes the double-stranded sequence TGCA, causes specific methylation on A-4 on both strands, and protects the DNA from cleavage by the CviRI endonuclease.

    Catalytic activityi

    S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

    GO - Molecular functioni

    1. nucleic acid binding Source: InterPro
    2. site-specific DNA-methyltransferase (adenine-specific) activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA restriction-modification system Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Restriction system

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Protein family/group databases

    REBASEi3355. M.CviRI.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Modification methylase CviRI (EC:2.1.1.72)
    Short name:
    M.CviRI
    Alternative name(s):
    Adenine-specific methyltransferase CviRI
    Gene namesi
    Name:CVIRIM
    OrganismiParamecium bursaria Chlorella virus XZ-6E (PBCV-XZ-6E)
    Taxonomic identifieri36360 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePhycodnaviridaeChlorovirusunclassified Chlorovirus
    Virus hostiChlorella [TaxID: 114049]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 379379Modification methylase CviRIPRO_0000087949Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP52284.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the N(4)/N(6)-methyltransferase family.Curated

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR002052. DNA_methylase_N6_adenine_CS.
    IPR002296. N12N6_MeTrfase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PRINTSiPR00507. N12N6MTFRASE.
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS00092. N6_MTASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P52284-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLFEDKSVE FHKRLSKKER SDGGVFFTPK DIRDIVFEEL GDFEPTNILE    50
    PTCGTGEFIS DCRKVYKNSR IIGVEIDPRS AELARDGSKN EIIVHDFMTW 100
    DTDEKFDLII GNPPYFTRPT GFKHDPSVVK CRSNICIEVL HKCITRHLAD 150
    NGMLAMVLPV SILNSKFYTP TIDLITDTMD VVSARAIKKN NFMGTNVRVM 200
    VFIIRKRTPG FVSKYTFKTS LGKVIINPDG ERLGSIVSGK KTIGSLNVNI 250
    SFGVTLASVK EYFVDKSCSG SFPLICYNNI AKKGDLLFVS DKYSKKRFNG 300
    RAILIPRGYA HGDYSFNFID YTNDYFIIEN HVIAITGEDC VLDIIAKSFA 350
    DHRTREFCRL LCSSGDISKD YVKEIPVFG 379
    Length:379
    Mass (Da):42,815
    Last modified:October 1, 1996 - v1
    Checksum:i22758935BB702BFA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M38173 Genomic DNA. Translation: AAA42900.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M38173 Genomic DNA. Translation: AAA42900.1 .

    3D structure databases

    ProteinModelPortali P52284.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    REBASEi 3355. M.CviRI.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR002052. DNA_methylase_N6_adenine_CS.
    IPR002296. N12N6_MeTrfase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    PRINTSi PR00507. N12N6MTFRASE.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS00092. N6_MTASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of the gene encoding the adenine methyltransferase M.CviRI from Chlorella virus XZ-6E."
      Stefan G., Xia Y., van Etten J.L.
      Nucleic Acids Res. 19:307-311(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiMTR1_PBCVX
    AccessioniPrimary (citable) accession number: P52284
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. Restriction enzymes and methylases
      Classification of restriction enzymes and methylases and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3