Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P52279

- PIP_XANCI

UniProt

P52279 - PIP_XANCI

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Proline iminopeptidase

Gene

pip

Organism
Xanthomonas campestris pv. citri (Xanthomonas citri)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in proline metabolism and sensitivity to ascamycin. Has ascamycin dealanylating activity.

Catalytic activityi

Release of N-terminal proline from a peptide.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei110 – 1101Nucleophile1 Publication
Active sitei266 – 26611 Publication
Active sitei294 – 2941Proton donor1 Publication

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Protein family/group databases

MEROPSiS33.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Proline iminopeptidase (EC:3.4.11.5)
Short name:
PIP
Alternative name(s):
Prolyl aminopeptidase
Short name:
PAP
Gene namesi
Name:pip
Synonyms:xap
OrganismiXanthomonas campestris pv. citri (Xanthomonas citri)
Taxonomic identifieri346 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Proline iminopeptidasePRO_0000080847Add
BLAST

Interactioni

Subunit structurei

Homooligomer.

Structurei

Secondary structure

1
313
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi11 – 177Combined sources
Beta strandi19 – 213Combined sources
Beta strandi23 – 308Combined sources
Beta strandi34 – 407Combined sources
Turni43 – 464Combined sources
Helixi50 – 556Combined sources
Turni58 – 603Combined sources
Beta strandi61 – 666Combined sources
Beta strandi74 – 763Combined sources
Helixi85 – 9814Combined sources
Beta strandi102 – 1098Combined sources
Helixi111 – 12212Combined sources
Helixi124 – 1263Combined sources
Beta strandi127 – 1348Combined sources
Helixi140 – 1478Combined sources
Helixi151 – 1544Combined sources
Helixi156 – 1649Combined sources
Helixi168 – 1703Combined sources
Helixi174 – 1829Combined sources
Helixi187 – 20317Combined sources
Beta strandi205 – 2084Combined sources
Helixi211 – 2177Combined sources
Helixi220 – 23516Combined sources
Helixi237 – 2393Combined sources
Helixi245 – 2484Combined sources
Helixi250 – 2534Combined sources
Beta strandi258 – 2636Combined sources
Beta strandi267 – 2693Combined sources
Helixi271 – 28010Combined sources
Beta strandi284 – 2896Combined sources
Helixi299 – 31214Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AZWX-ray2.70A/B1-313[»]
ProteinModelPortaliP52279.
SMRiP52279. Positions 1-313.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP52279.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S33 family.Curated

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR002410. Peptidase_S33.
IPR005944. Pro_iminopeptidase.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PIRSFiPIRSF006431. Pept_S33. 1 hit.
PRINTSiPR00793. PROAMNOPTASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR01249. pro_imino_pep_1. 1 hit.

Sequencei

Sequence statusi: Complete.

P52279-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRTLYPEITP YQQGSLKVDD RHTLYFEQCG NPHGKPVVML HGGPGGGCND
60 70 80 90 100
KMRRFHDPAK YRIVLFDQRG SGRSTPHADL VDNTTWDLVA DIERLRTHLG
110 120 130 140 150
VDRWQVFGGS WGSTLALAYA ADPSAAGHQL VLRGIFLLRR FELEWFYQEG
160 170 180 190 200
ASRLFPDAWE HYLNAIPPVE RADLMSAFHR RLTSDDEATR LAAAKAWSVW
210 220 230 240 250
EGATSFLHVD EDFVTGHEDA HFALAFARIE NHYFVNGGFF EVEDQLLRDA
260 270 280 290 300
HRIADIPGVI VHGRYDVVCP LQSAWDLHKA WPKAQLQISP ASGHSAFEPE
310
NVDALVRATD GFA
Length:313
Mass (Da):35,260
Last modified:November 1, 1997 - v2
Checksum:i7A9DF2636363FF48
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti95 – 951L → V in BAA11623. (PubMed:8870654)Curated
Sequence conflicti121 – 1299ADPSAAGHQ → QTHPQQVTE in BAA11623. (PubMed:8870654)Curated
Sequence conflicti245 – 2517QLLRDAH → SCCATD in BAA11623. (PubMed:8870654)Curated
Sequence conflicti284 – 2841Missing in BAA11623. (PubMed:8870654)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z54150 Genomic DNA. Translation: CAA90864.1.
D82882 Genomic DNA. Translation: BAA11623.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z54150 Genomic DNA. Translation: CAA90864.1 .
D82882 Genomic DNA. Translation: BAA11623.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1AZW X-ray 2.70 A/B 1-313 [» ]
ProteinModelPortali P52279.
SMRi P52279. Positions 1-313.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S33.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P52279.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR002410. Peptidase_S33.
IPR005944. Pro_iminopeptidase.
[Graphical view ]
Pfami PF00561. Abhydrolase_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF006431. Pept_S33. 1 hit.
PRINTSi PR00793. PROAMNOPTASE.
SUPFAMi SSF53474. SSF53474. 1 hit.
TIGRFAMsi TIGR01249. pro_imino_pep_1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Proline iminopeptidase gene from Xanthomonas campestris pv. citri."
    Alonso J., Garcia J.L.
    Microbiology 142:2951-2957(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: NBRC 3835.
  2. Alonso J.
    Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "Isolation and characterization of the gene encoding an aminopeptidase involved in the selective toxicity of ascamycin toward Xanthomonas campestris pv. citri."
    Sudo T., Shinohara K., Dohmae N., Takio K., Usami R., Horikoshi K., Osada H.
    Biochem. J. 319:99-102(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-20 AND 283-296.
    Strain: NBRC 3781.
  4. "Structure of proline iminopeptidase from Xanthomonas campestris pv. citri: a prototype for the prolyl oligopeptidase family."
    Medrano F.J., Alonso J., Garcia J.L., Romero A., Bode W., Gomis-Ruth F.X.
    EMBO J. 17:1-9(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS), ACTIVE SITE.

Entry informationi

Entry nameiPIP_XANCI
AccessioniPrimary (citable) accession number: P52279
Secondary accession number(s): P96186
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3