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Protein

Heterogeneous nuclear ribonucleoprotein M

Gene

HNRNPM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines.

GO - Molecular functioni

  • protein domain specific binding Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-HSA-6803529 FGFR2 alternative splicing
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA
SIGNORiP52272

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein M
Short name:
hnRNP M
Gene namesi
Name:HNRNPM
Synonyms:HNRPM, NAGR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000099783.11
HGNCiHGNC:5046 HNRNPM
MIMi160994 gene
neXtProtiNX_P52272

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi4670
OpenTargetsiENSG00000099783
PharmGKBiPA29370

Polymorphism and mutation databases

BioMutaiHNRNPM
DMDMi55977747

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00000818642 – 730Heterogeneous nuclear ribonucleoprotein MAdd BLAST729

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Cross-linki17Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei29PhosphoserineCombined sources1
Cross-linki37Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki69Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki83Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei86PhosphoserineCombined sources1
Cross-linki88Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki127Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei134N6-acetyllysine; alternateBy similarity1
Cross-linki134Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki143Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki145Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei204PhosphoserineCombined sources1
Cross-linki221Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei277N6-acetyllysine; alternateCombined sources1
Cross-linki277Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki285Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki345Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei365PhosphoserineCombined sources1
Modified residuei377PhosphoserineCombined sources1
Cross-linki381Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki388Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei397PhosphoserineCombined sources1
Modified residuei432PhosphoserineCombined sources1
Modified residuei452PhosphoserineCombined sources1
Modified residuei468PhosphoserineCombined sources1
Modified residuei481PhosphoserineCombined sources1
Modified residuei496Omega-N-methylarginineCombined sources1
Modified residuei528PhosphoserineCombined sources1
Modified residuei575PhosphoserineCombined sources1
Modified residuei588PhosphoserineCombined sources1
Modified residuei618PhosphoserineCombined sources1
Modified residuei633PhosphoserineCombined sources1
Modified residuei637PhosphoserineCombined sources1
Cross-linki651Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei665PhosphothreonineCombined sources1
Cross-linki667Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei672N6-acetyllysineBy similarity1
Cross-linki685Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki692Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei698N6-acetyllysine; alternateCombined sources1
Cross-linki698Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki698Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei701PhosphoserineCombined sources1
Cross-linki716Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Post-translational modificationi

Sumoylated.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP52272
PaxDbiP52272
PeptideAtlasiP52272
PRIDEiP52272
ProteomicsDBi56473
56474 [P52272-2]

2D gel databases

REPRODUCTION-2DPAGEiIPI00383296
UCD-2DPAGEiP52272

PTM databases

iPTMnetiP52272
PhosphoSitePlusiP52272
SwissPalmiP52272

Expressioni

Gene expression databases

BgeeiENSG00000099783
CleanExiHS_HNRNPM
ExpressionAtlasiP52272 baseline and differential
GenevisibleiP52272 HS

Organism-specific databases

HPAiCAB016113
HPA024344

Interactioni

Subunit structurei

Identified in the spliceosome C complex.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • protein domain specific binding Source: UniProtKB

Protein-protein interaction databases

BioGridi110751, 259 interactors
CORUMiP52272
DIPiDIP-29336N
IntActiP52272, 80 interactors
MINTiP52272
STRINGi9606.ENSP00000325376

Structurei

Secondary structure

1730
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi206 – 210Combined sources5
Helixi217 – 224Combined sources8
Turni225 – 227Combined sources3
Beta strandi230 – 237Combined sources8
Beta strandi242 – 253Combined sources12
Helixi254 – 264Combined sources11
Beta strandi275 – 278Combined sources4
Beta strandi654 – 657Combined sources4
Helixi666 – 674Combined sources9
Beta strandi679 – 689Combined sources11
Beta strandi691 – 701Combined sources11
Helixi702 – 712Combined sources11
Beta strandi725 – 727Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DGVNMR-A652-730[»]
2DH9NMR-A655-730[»]
2DO0NMR-A196-296[»]
2OT8X-ray3.10C/D41-70[»]
ProteinModelPortaliP52272
SMRiP52272
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP52272

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini71 – 149RRM 1PROSITE-ProRule annotationAdd BLAST79
Domaini204 – 281RRM 2PROSITE-ProRule annotationAdd BLAST78
Repeati400 – 40516
Repeati407 – 41226
Repeati415 – 42036
Repeati426 – 43146
Repeati433 – 43856
Repeati440 – 44566
Repeati446 – 45176
Repeati453 – 45886
Repeati461 – 46696
Repeati468 – 473106
Repeati475 – 480116
Repeati482 – 487126
Repeati493 – 498136
Repeati500 – 505146
Repeati507 – 512156
Repeati514 – 519166
Repeati521 – 526176
Repeati528 – 533186
Repeati540 – 545196
Repeati547 – 552206
Repeati554 – 559216
Repeati562 – 566225
Repeati567 – 572236
Repeati575 – 579245
Repeati580 – 585256
Repeati588 – 593266
Repeati603 – 608276
Domaini653 – 729RRM 3PROSITE-ProRule annotationAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni400 – 60827 X 6 AA repeats of [GEVSTPAN]-[ILMV]-[DE]-[RH]-[MLVI]-[GAV]Add BLAST209

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi390 – 396Poly-Gly7
Compositional biasi612 – 616Poly-Gly5

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4212 Eukaryota
COG0724 LUCA
GeneTreeiENSGT00410000025635
HOGENOMiHOG000231932
HOVERGENiHBG054880
InParanoidiP52272
KOiK12887
OMAiCGVVRFE
PhylomeDBiP52272
TreeFamiTF313406

Family and domain databases

CDDicd12661 RRM3_hnRNPM, 1 hit
Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR024667 HnRNP_M
IPR024666 HnRNP_M_PY-NLS
IPR034990 hnRNPM_RRM3
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PANTHERiPTHR23003:SF6 PTHR23003:SF6, 1 hit
PfamiView protein in Pfam
PF11532 HnRNP_M, 1 hit
PF00076 RRM_1, 3 hits
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF54928 SSF54928, 3 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Experimental confirmation may be lacking for some isoforms.
Isoform 1 (identifier: P52272-1) [UniParc]FASTAAdd to basket
Also known as: M4

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAGVEAAAE VAATEIKMEE ESGAPGVPSG NGAPGPKGEG ERPAQNEKRK
60 70 80 90 100
EKNIKRGGNR FEPYANPTKR YRAFITNIPF DVKWQSLKDL VKEKVGEVTY
110 120 130 140 150
VELLMDAEGK SRGCAVVEFK MEESMKKAAE VLNKHSLSGR PLKVKEDPDG
160 170 180 190 200
EHARRAMQKV MATTGGMGMG PGGPGMITIP PSILNNPNIP NEIIHALQAG
210 220 230 240 250
RLGSTVFVAN LDYKVGWKKL KEVFSMAGVV VRADILEDKD GKSRGIGTVT
260 270 280 290 300
FEQSIEAVQA ISMFNGQLLF DRPMHVKMDE RALPKGDFFP PERPQQLPHG
310 320 330 340 350
LGGIGMGLGP GGQPIDANHL NKGIGMGNIG PAGMGMEGIG FGINKMGGME
360 370 380 390 400
GPFGGGMENM GRFGSGMNMG RINEILSNAL KRGEIIAKQG GGGGGGSVPG
410 420 430 440 450
IERMGPGIDR LGGAGMERMG AGLGHGMDRV GSEIERMGLV MDRMGSVERM
460 470 480 490 500
GSGIERMGPL GLDHMASSIE RMGQTMERIG SGVERMGAGM GFGLERMAAP
510 520 530 540 550
IDRVGQTIER MGSGVERMGP AIERMGLSME RMVPAGMGAG LERMGPVMDR
560 570 580 590 600
MATGLERMGA NNLERMGLER MGANSLERMG LERMGANSLE RMGPAMGPAL
610 620 630 640 650
GAGIERMGLA MGGGGGASFD RAIEMERGNF GGSFAGSFGG AGGHAPGVAR
660 670 680 690 700
KACQIFVRNL PFDFTWKMLK DKFNECGHVL YADIKMENGK SKGCGVVKFE
710 720 730
SPEVAERACR MMNGMKLSGR EIDVRIDRNA
Length:730
Mass (Da):77,516
Last modified:January 23, 2007 - v3
Checksum:i1A73DD35A3501861
GO
Isoform 2 (identifier: P52272-2) [UniParc]FASTAAdd to basket
Also known as: M1-M2

The sequence of this isoform differs from the canonical sequence as follows:
     160-198: Missing.

Show »
Length:691
Mass (Da):73,621
Checksum:i028646C136D3CBD1
GO
Isoform 3 (identifier: P52272-3)
Also known as: M3
Sequence is not available
Length:
Mass (Da):

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24 – 34APGVPSGNGAP → GPACERQRGS in AAA36192 (PubMed:8441656).CuratedAdd BLAST11
Sequence conflicti34P → S in AAC16002 (Ref. 3) Curated1
Sequence conflicti51E → V in AAA36192 (PubMed:8441656).Curated1
Sequence conflicti152H → C in AAC16002 (Ref. 3) Curated1
Sequence conflicti527L → P (PubMed:8441656).Curated1
Sequence conflicti527L → P (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_005845160 – 198Missing in isoform 2. 3 PublicationsAdd BLAST39

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L03532 mRNA Translation: AAA36192.1
L32611 mRNA Translation: AAL31359.1
AF061832 mRNA Translation: AAC16002.1
BC000138 mRNA Translation: AAH00138.2
BC008895 mRNA Translation: AAH08895.2
BC019580 mRNA Translation: AAH19580.1
CCDSiCCDS12203.1 [P52272-1]
CCDS12204.1 [P52272-2]
PIRiS35532
RefSeqiNP_005959.2, NM_005968.4 [P52272-1]
NP_112480.2, NM_031203.3 [P52272-2]
UniGeneiHs.465808
Hs.666214

Genome annotation databases

EnsembliENST00000325495; ENSP00000325376; ENSG00000099783 [P52272-1]
ENST00000348943; ENSP00000325732; ENSG00000099783 [P52272-2]
GeneIDi4670
KEGGihsa:4670
UCSCiuc010dwd.4 human [P52272-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiHNRPM_HUMAN
AccessioniPrimary (citable) accession number: P52272
Secondary accession number(s): Q15584
, Q8WZ44, Q96H56, Q9BWL9, Q9Y492
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 189 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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