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Protein

Thioredoxin

Gene

trxA

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin
Short name:
Trx
Gene namesi
Name:trxA
Ordered Locus Names:slr0623
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001201382 – 107ThioredoxinAdd BLAST106

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 35Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
apcEQ555444EBI-862916,EBI-862826
argGP779732EBI-862916,EBI-862317
cbbLP542053EBI-862916,EBI-862277
ccmMP727582EBI-862916,EBI-862848
fusAP283712EBI-862916,EBI-862177
gltBP550372EBI-862916,EBI-862093
groL1Q059724EBI-862916,EBI-862119
pgmP746432EBI-862916,EBI-862197
rfbDP725862EBI-862916,EBI-862716
rpsCP733145EBI-862916,EBI-862866
sirP728543EBI-862916,EBI-862835
sll1621P737283EBI-862916,EBI-862771
slr1198P733484EBI-862916,EBI-862753
tufP742275EBI-862916,EBI-862703

Protein-protein interaction databases

IntActiP52231. 103 interactors.

Structurei

3D structure databases

ProteinModelPortaliP52231.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 107ThioredoxinPROSITE-ProRule annotationAdd BLAST106

Sequence similaritiesi

Belongs to the thioredoxin family.Curated
Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center

Phylogenomic databases

HOGENOMiHOG000292977.
InParanoidiP52231.
KOiK03671.
OMAiKKTYTDA.
PhylomeDBiP52231.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
PIRSFiPIRSF000077. Thioredoxin. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01068. thioredoxin. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52231-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSATPQVSDA SFKEDVLDSE LPVLVDFWAP WCGPCRMVAP VVDEISQQYE
60 70 80 90 100
GKVKVVKLNT DENPNTASQY GIRSIPTLMI FKGGQRVDMV VGAVPKTTLA

STLEKYL
Length:107
Mass (Da):11,749
Last modified:January 23, 2007 - v3
Checksum:iC03FAA09EACEC333
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80486 Genomic DNA. Translation: CAA56653.1.
BA000022 Genomic DNA. Translation: BAA10623.1.
PIRiS46958.

Genome annotation databases

EnsemblBacteriaiBAA10623; BAA10623; BAA10623.
KEGGisyn:slr0623.
PATRICi23842830. VBISynSp132158_2954.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80486 Genomic DNA. Translation: CAA56653.1.
BA000022 Genomic DNA. Translation: BAA10623.1.
PIRiS46958.

3D structure databases

ProteinModelPortaliP52231.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP52231. 103 interactors.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA10623; BAA10623; BAA10623.
KEGGisyn:slr0623.
PATRICi23842830. VBISynSp132158_2954.

Phylogenomic databases

HOGENOMiHOG000292977.
InParanoidiP52231.
KOiK03671.
OMAiKKTYTDA.
PhylomeDBiP52231.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
PIRSFiPIRSF000077. Thioredoxin. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01068. thioredoxin. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTHIO_SYNY3
AccessioniPrimary (citable) accession number: P52231
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.