Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Thioredoxin-1

Gene

trxA

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Stimulates complex formation between sigma factor SigR and its cognate anti-sigma factor RsrA probably by reducing RsrA.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin-1
Short name:
Trx-1
Gene namesi
Name:trxA
Ordered Locus Names:SCO3889
ORF Names:SCH24.11c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 110110Thioredoxin-1PRO_0000120136Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 36Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP52230.

Expressioni

Inductioni

Expressed from 2 promoters, 1 of which (trxBp1) is under control of SigR, and further transiently induced (about 50-fold) by the thiol-oxidizing agent diamide. Part of the trxB-trxA operon.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO3889.

Structurei

Secondary structure

1
110
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 83Combined sources
Turni10 – 123Combined sources
Helixi13 – 164Combined sources
Turni17 – 193Combined sources
Beta strandi24 – 296Combined sources
Helixi34 – 4916Combined sources
Turni50 – 534Combined sources
Beta strandi55 – 606Combined sources
Turni61 – 633Combined sources
Helixi65 – 706Combined sources
Beta strandi75 – 839Combined sources
Beta strandi86 – 938Combined sources
Helixi97 – 1037Combined sources
Helixi105 – 1084Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1T00X-ray1.51A1-110[»]
ProteinModelPortaliP52230.
SMRiP52230. Positions 1-110.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP52230.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 109108ThioredoxinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the thioredoxin family.Curated
Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG4105K63. Bacteria.
COG0526. LUCA.
HOGENOMiHOG000292977.
InParanoidiP52230.
KOiK03671.
OMAiKKTYTDA.
OrthoDBiPOG091H03UW.
PhylomeDBiP52230.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
PIRSFiPIRSF000077. Thioredoxin. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01068. thioredoxin. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52230-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGTLKHVTD DSFEQDVLKN DKPVLVDFWA AWCGPCRQIA PSLEAIAAEY
60 70 80 90 100
GDKIEIVKLN IDENPGTAAK YGVMSIPTLN VYQGGEVAKT IVGAKPKAAI
110
VRDLEDFIAD
Length:110
Mass (Da):11,892
Last modified:June 1, 2001 - v4
Checksum:i18AA0F89F7E513A8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti95 – 962KP → NA in CAA63074 (PubMed:9795152).Curated
Sequence conflicti95 – 962KP → NA in CAA07452 (PubMed:9795152).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92105 Genomic DNA. Translation: CAA63077.1.
X92103 Genomic DNA. Translation: CAA63074.1.
AJ007313 Genomic DNA. Translation: CAA07452.1.
AF031590 Genomic DNA. Translation: AAC03481.1.
AF187159 Genomic DNA. Translation: AAF16002.1.
AL939118 Genomic DNA. Translation: CAB42711.1.
PIRiT36576.
T42061.
RefSeqiNP_628075.1. NC_003888.3.
WP_003975042.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB42711; CAB42711; CAB42711.
GeneIDi1099325.
KEGGisco:SCO3889.
PATRICi23737562. VBIStrCoe124346_3962.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92105 Genomic DNA. Translation: CAA63077.1.
X92103 Genomic DNA. Translation: CAA63074.1.
AJ007313 Genomic DNA. Translation: CAA07452.1.
AF031590 Genomic DNA. Translation: AAC03481.1.
AF187159 Genomic DNA. Translation: AAF16002.1.
AL939118 Genomic DNA. Translation: CAB42711.1.
PIRiT36576.
T42061.
RefSeqiNP_628075.1. NC_003888.3.
WP_003975042.1. NC_003888.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1T00X-ray1.51A1-110[»]
ProteinModelPortaliP52230.
SMRiP52230. Positions 1-110.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO3889.

Proteomic databases

PRIDEiP52230.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB42711; CAB42711; CAB42711.
GeneIDi1099325.
KEGGisco:SCO3889.
PATRICi23737562. VBIStrCoe124346_3962.

Phylogenomic databases

eggNOGiENOG4105K63. Bacteria.
COG0526. LUCA.
HOGENOMiHOG000292977.
InParanoidiP52230.
KOiK03671.
OMAiKKTYTDA.
OrthoDBiPOG091H03UW.
PhylomeDBiP52230.

Miscellaneous databases

EvolutionaryTraceiP52230.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
PIRSFiPIRSF000077. Thioredoxin. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01068. thioredoxin. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTHIO1_STRCO
AccessioniPrimary (citable) accession number: P52230
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 119 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.