Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot P52213 (TRXB_CLOLI)

Last modified June 16, 2009. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Thioredoxin reductase
      Short name=TRXR
    EC=1.8.1.9
Gene names
Name: trxB
OrganismClostridium litorale (Bacterium W6)
Taxonomic identifier1557 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

Thioredoxin + NADP+ = thioredoxin disulfide + NADPH.

Cofactor

Binds 1 FAD per subunit By similarity.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Miscellaneous

The active site is a redox-active disulfide bond.

Sequence similarities

Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 315315Thioredoxin reductase
PRO_0000166727

Regions

Nucleotide binding34 – 418FAD By similarity
Nucleotide binding282 – 29110FAD By similarity

Amino acid modifications

Disulfide bond134 ↔ 137Redox-active By similarity

Sequences

Sequence LengthMass (Da)Tools
P52213-1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 2CA55D36E579E2EF

FASTA31533,946
        10         20         30         40         50         60 
MENVYDIAII GSGPAGLAAA LYGARAKMKT LLLEGMKVGG QIVITHEVAN YPGSVPEATG 

        70         80         90        100        110        120 
PSLIGRMEEQ VEEFGAERVM DNIVDVDFTD KIKVLKGAKG EYKAKAVIVA TGASPKLAGC 

       130        140        150        160        170        180 
PGEKELTGKG VSYCATCDAD FFEDMEVFVI GGGDTAVEEA MFLTKFARKV TIVHRRAELR 

       190        200        210        220        230        240 
AAKSIQEKAF KNEKLNFMWN TVIEEIKGDG IVESAVFKNR ETGEVTEFVA PEEDGTFGIF 

       250        260        270        280        290        300 
VFIGYDPKSA LVEGKLELDE TGYIPTDDNM KTNVEGVFAA GDIRVKSLRQ VVTATADGAI 

       310 
AAVQAEKYIE ELFAE 

« Hide

References

[1]"Glycine reductase of Clostridium litorale. Cloning, sequencing, and molecular analysis of the grdAB operon that contains two in-frame TGA codons for selenium incorporation."
Kreimer S., Andreesen J.R.
Eur. J. Biochem. 234:192-199(1995) [PubMed: 8529640] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

U24268 Genomic DNA. Translation: AAC43575.1.
PIRS63990.

3D structure databases

HSSPHSSP built from PDB template 1VDC based on UniProtKB Q39243.
ModBaseSearch...

Enzyme and pathway databases

BRENDA1.8.1.9. 266700.

Family and domain databases

InterProIPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR008255. Pyr_nucl-diS_OxRdtase_2_AS.
IPR001327. Pyr_OxRdtase_NAD_bd.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
IPR005982. Thioredox_Rdtase.
[Graphical view]
PfamPF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSPR00368. FADPNR.
PR00469. PNDRDTASEII.
ProDomPD000139. FAD_pyr_redox. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR01292. TRX_reduct. 1 hit.
PROSITEPS00573. PYRIDINE_REDOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRXB_CLOLI
AccessionPrimary (citable) accession number: P52213
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 16, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents