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P52210

- ALDOB_SHEEP

UniProt

P52210 - ALDOB_SHEEP

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Protein
Fructose-bisphosphate aldolase B
Gene
ALDOB
Organism
Ovis aries (Sheep)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei56 – 561Substrate
Binding sitei147 – 1471Substrate
Active sitei188 – 1881Proton acceptor By similarity
Active sitei230 – 2301Schiff-base intermediate with dihydroxyacetone-P
Sitei364 – 3641Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase B (EC:4.1.2.13)
Alternative name(s):
Liver-type aldolase
Gene namesi
Name:ALDOB
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
ProteomesiUP000002356: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. microtubule organizing center Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 364363Fructose-bisphosphate aldolase B
PRO_0000216944Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei13 – 131N6-succinyllysine By similarity
Modified residuei36 – 361Phosphoserine By similarity
Modified residuei39 – 391Phosphothreonine By similarity
Modified residuei121 – 1211N6-succinyllysine By similarity
Modified residuei317 – 3171N6-succinyllysine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Interactioni

Subunit structurei

Homotetramer By similarity. Interacts with BBS1, BBS2, BBS4 and BBS7 By similarity.

Structurei

3D structure databases

ProteinModelPortaliP52210.
SMRiP52210. Positions 2-345.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG002386.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR000741. FBA_I.
[Graphical view]
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52210-1 [UniParc]FASTAAdd to Basket

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MAHQFPALTS EQKKALSETA RRIVANGKGI LAADESVGTM GNRLQRIKVE    50
NTEENRRQFR ELLFTVDSSV SQSIGGVILF HETLYQKDGQ GKLFRDILKE 100
KGIVVGIKLD QGVAPLAGTN KETTVQGLDG LSERCAQYKK DGADFGKWRA 150
VLKIDNQCPS HLAIQENANT LARYASIYQQ NGLVPIVEPE VIPDGSHDME 200
HCQYVTEKVL AAVYKALNDH HVYLEGTLLK PNMVTAGHAC TKKYTPEQVA 250
MATVTALHRT VPAAVPGICF LSGGMSEEDA TLNLNAINLC PLPKPWKLSF 300
SYGRALQASA LAAWGGKAEN KKATQEAFMK RALANSQAAK GQYVHMGSSD 350
SASTQSLFTA SYTY 364
Length:364
Mass (Da):39,631
Last modified:January 23, 2007 - v2
Checksum:i935F4A91D6C6BFDF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z29372 mRNA. Translation: CAA82563.1.
PIRiS47540.
RefSeqiNP_001009809.1. NM_001009809.1.
UniGeneiOar.484.

Genome annotation databases

GeneIDi443440.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z29372 mRNA. Translation: CAA82563.1 .
PIRi S47540.
RefSeqi NP_001009809.1. NM_001009809.1.
UniGenei Oar.484.

3D structure databases

ProteinModelPortali P52210.
SMRi P52210. Positions 2-345.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 443440.

Organism-specific databases

CTDi 229.

Phylogenomic databases

HOVERGENi HBG002386.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR000741. FBA_I.
[Graphical view ]
Pfami PF00274. Glycolytic. 1 hit.
[Graphical view ]
PROSITEi PS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of a full-length cDNA coding for ovine aldolase B from fetal mesonephros."
    Gianquinto L., Pailhoux E.A., Bezard J., Servel N., Kirszenbaum M., Cotinot C.
    Biochim. Biophys. Acta 1219:223-227(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Mesonephros.

Entry informationi

Entry nameiALDOB_SHEEP
AccessioniPrimary (citable) accession number: P52210
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

In vertebrates, 3 forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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