Reviewed,
UniProtKB/Swiss-Prot P52209 (6PGD_HUMAN)
Last modified
June 16, 2009.
Version 90.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and origin
| Protein names | Recommended name: 6-phosphogluconate dehydrogenase, decarboxylating EC=1.1.1.44 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 483 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Catalytic activity | 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. |
| Pathway | |
| Subunit structure | Homodimer By similarity. |
| Sequence similarities | Belongs to the 6-phosphogluconate dehydrogenase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Pentose shunt |
| Coding sequence diversity | Polymorphism |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from direct assay. Source: UniProtKB pentose-phosphate shunt, oxidative branchInferred from direct assay. Source: UniProtKB |
| Molecular function | NADP or NADPH binding Inferred from electronic annotation. Source: InterPro phosphogluconate dehydrogenase (decarboxylating) activityInferred from electronic annotation. Source: EC protein bindingInferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed By similarity | ||||||
| Chain | 2 – 483 | 482 | 6-phosphogluconate dehydrogenase, decarboxylating | PRO_0000090063 | |||||
Natural variations | |||||||||
| Natural variant | 268 | 1 | A → S: dbSNP rs11547610. | VAR_048104 | |||||
Experimental info | |||||||||
| Sequence conflict | 118 | 1 | A → G in AAA75302. Ref.1 | ||||||
| Sequence conflict | 135 | 1 | A → P in AAA75302. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Identification of a cDNA encoding 6-phosphogluconate dehydrogenase from a human heart cDNA library." Tsui S.K.W., Chan J.Y., Waye M.M.Y., Fung K.-P., Lee C.-Y. Biochem. Genet. 34:367-373(1996) [PubMed: 8978909] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Heart. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung. |
| [3] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
Cross-references
Sequence databases | |
|---|---|
| U30255 mRNA. Translation: AAA75302.1. BC000368 mRNA. Translation: AAH00368.1. | |
| IPI | IPI00219525. |
| PIR | G01922. |
| RefSeq | NP_002622.2. |
| UniGene | Hs.464071 |
3D structure databases | |
| HSSP | HSSP built from PDB template 2PGD based on UniProtKB P00349. |
| SMR | P52209. Positions 2-474. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P52209. 7 interactions. |
Proteomic databases | |
| PeptideAtlas | P52209. |
| PRIDE | P52209. |
Genome annotation databases | |
| Ensembl | ENSG00000142657. Homo sapiens. [Contig view] |
| GeneID | 5226. |
| KEGG | hsa:5226. |
Organism-specific databases | |
| GeneCards | GC01P010393. |
| H-InvDB | HIX0000112. |
| HGNC | HGNC:8891. PGD. |
| MIM | 172200. gene. |
| PharmGKB | PA29424. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | P52209. |
Enzyme and pathway databases | |
| BRENDA | 1.1.1.44. 247. |
| Reactome | REACT_474. Metabolism of carbohydrates. |
Gene expression databases | |
| ArrayExpress | P52209. |
| Bgee | P52209. |
| CleanEx | HS_PGD. |
| GermOnline | ENSG00000142657. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR006183. 6-phosphogluconate_DH. IPR006114. 6PGDH_C. IPR006113. 6PGDH_decarbox. IPR006115. 6PGDH_NAD-bd. IPR006184. 6PGdom_BS. IPR013328. DH_multihelical. IPR012284. Fibritin/6PGD_C-extension. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| Gene3D | G3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit. |
| Pfam | PF00393. 6PGD. 1 hit. PF03446. NAD_binding_2. 1 hit. [Graphical view] |
| PRINTS | PR00076. 6PGDHDRGNASE. |
| TIGRFAMs | TIGR00873. gnd. 1 hit. |
| PROSITE | PS00461. 6PGD. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 20204. |
| SOURCE | Search... |
Entry information
| Entry name | 6PGD_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P52209 Secondary accession number(s): Q9BWD8 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 1 Human chromosome 1: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


