Reviewed, UniProtKB/Swiss-Prot P52209 (6PGD_HUMAN)

Names and origin

Protein names

Recommended name:
    6-phosphogluconate dehydrogenase, decarboxylating
    EC=1.1.1.44

Gene names

Name:	PGD
Synonyms:	PGDH

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	483 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the 6-phosphogluconate dehydrogenase family.

Ontologies

Keywords
Biological process	Pentose shunt
Coding sequence diversity	Polymorphism
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from direct assay. Source: UniProtKB pentose-phosphate shunt, oxidative branch Inferred from direct assay. Source: UniProtKB
Molecular function	NADP or NADPH binding Inferred from electronic annotation. Source: InterPro phosphogluconate dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
LSM8	O95777	1	EBI-372761,EBI-347779

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 483	482	6-phosphogluconate dehydrogenase, decarboxylating		PRO_0000090063
Natural variations
	Natural variant	268	1	A → S: dbSNP rs11547610.		VAR_048104
Experimental info
	Sequence conflict	118	1	A → G in AAA75302. Ref.1
	Sequence conflict	135	1	A → P in AAA75302. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P52209-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 6CEFC0077D1283E3	FASTA	483	53,140
	10 20 30 40 50 60 MAQADIALIG LAVMGQNLIL NMNDHGFVVC AFNRTVSKVD DFLANEAKGT KVVGAQSLKE 70 80 90 100 110 120 MVSKLKKPRR IILLVKAGQA VDDFIEKLVP LLDTGDIIID GGNSEYRDTT RRCRDLKAKG 130 140 150 160 170 180 ILFVGSGVSG GEEGARYGPS LMPGGNKEAW PHIKTIFQGI AAKVGTGEPC CDWVGDEGAG 190 200 210 220 230 240 HFVKMVHNGI EYGDMQLICE AYHLMKDVLG MAQDEMAQAF EDWNKTELDS FLIEITANIL 250 260 270 280 290 300 KFQDTDGKHL LPKIRDSAGQ KGTGKWTAIS ALEYGVPVTL IGEAVFARCL SSLKDERIQA 310 320 330 340 350 360 SKKLKGPQKF QFDGDKKSFL EDIRKALYAS KIISYAQGFM LLRQAATEFG WTLNYGGIAL 370 380 390 400 410 420 MWRGGCIIRS VFLGKIKDAF DRNPELQNLL LDDFFKSAVE NCQDSWRRAV STGVQAGIPM 430 440 450 460 470 480 PCFTTALSFY DGYRHEMLPA SLIQAQRDYF GAHTYELLAK PGQFIHTNWT GHGGTVSSSS YNA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a cDNA encoding 6-phosphogluconate dehydrogenase from a human heart cDNA library." Tsui S.K.W., Chan J.Y., Waye M.M.Y., Fung K.-P., Lee C.-Y. Biochem. Genet. 34:367-373(1996) [PubMed: 8978909] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Heart.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[3]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U30255 mRNA. Translation: AAA75302.1. BC000368 mRNA. Translation: AAH00368.1.
IPI	IPI00219525.
PIR	G01922.
RefSeq	NP_002622.2.
UniGene	Hs.464071
3D structure databases
HSSP	HSSP built from PDB template 2PGD based on UniProtKB P00349.
SMR	P52209. Positions 2-474.
ModBase	Search...
Protein-protein interaction databases
IntAct	P52209. 7 interactions.
Proteomic databases
PeptideAtlas	P52209.
PRIDE	P52209.
Genome annotation databases
Ensembl	ENSG00000142657. Homo sapiens. [Contig view]
GeneID	5226.
KEGG	hsa:5226.
Organism-specific databases
GeneCards	GC01P010393.
H-InvDB	HIX0000112.
HGNC	HGNC:8891. PGD.
MIM	172200. gene.
PharmGKB	PA29424.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	P52209.
Enzyme and pathway databases
BRENDA	1.1.1.44. 247.
Reactome	REACT_474. Metabolism of carbohydrates.
Gene expression databases
ArrayExpress	P52209.
Bgee	P52209.
CleanEx	HS_PGD.
GermOnline	ENSG00000142657. Homo sapiens.
Family and domain databases
InterPro	IPR006183. 6-phosphogluconate_DH. IPR006114. 6PGDH_C. IPR006113. 6PGDH_decarbox. IPR006115. 6PGDH_NAD-bd. IPR006184. 6PGdom_BS. IPR013328. DH_multihelical. IPR012284. Fibritin/6PGD_C-extension. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF00393. 6PGD. 1 hit. PF03446. NAD_binding_2. 1 hit. [Graphical view]
PRINTS	PR00076. 6PGDHDRGNASE.
TIGRFAMs	TIGR00873. gnd. 1 hit.
PROSITE	PS00461. 6PGD. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	20204.
SOURCE	Search...

Entry information

Entry name

6PGD_HUMAN

Accession

Primary (citable) accession number: P52209
Secondary accession number(s): Q9BWD8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	January 23, 2007
Last modified:	June 16, 2009
This is version 90 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)