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P52208

- 6PGD_SYNY3

UniProt

P52208 - 6PGD_SYNY3

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Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene

gnd

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.By similarity

Catalytic activityi

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei110 – 1101NADPBy similarity
Binding sitei110 – 1101SubstrateBy similarity
Active sitei193 – 1931Proton acceptorBy similarity
Active sitei200 – 2001Proton donorBy similarity
Binding sitei201 – 2011SubstrateBy similarity
Binding sitei272 – 2721Substrate; via amide nitrogenBy similarity
Binding sitei299 – 2991SubstrateBy similarity
Binding sitei457 – 4571Substrate; shared with dimeric partnerBy similarity
Binding sitei463 – 4631Substrate; shared with dimeric partnerBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi17 – 226NADPBy similarity
Nucleotide bindingi40 – 423NADPBy similarity
Nucleotide bindingi82 – 843NADPBy similarity

GO - Molecular functioni

  1. NADP binding Source: InterPro
  2. phosphogluconate dehydrogenase (decarboxylating) activity Source: UniProtKB-EC

GO - Biological processi

  1. D-gluconate metabolic process Source: UniProtKB-KW
  2. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Gluconate utilization, Pentose shunt

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciSSP1148:GJOT-2172-MONOMER.
UniPathwayiUPA00115; UER00410.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconate dehydrogenase, decarboxylating (EC:1.1.1.44)
Gene namesi
Name:gnd
Ordered Locus Names:sll0329
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4824826-phosphogluconate dehydrogenase, decarboxylatingPRO_0000090061Add
BLAST

Proteomic databases

PaxDbiP52208.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi1148.sll0329.

Structurei

3D structure databases

ProteinModelPortaliP52208.
SMRiP52208. Positions 8-482.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni136 – 1383Substrate bindingBy similarity
Regioni196 – 1972Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0362.
HOGENOMiHOG000255147.
InParanoidiP52208.
KOiK00033.
OMAiDKDGVFH.
OrthoDBiEOG6MSS4W.
PhylomeDBiP52208.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000109. 6PGD. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00873. gnd. 1 hit.
PROSITEiPS00461. 6PGD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52208-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQFNVAIMTK RTFGVIGLAV MGENLALNVE SRGFPIAVFN RSPNKTEKFM
60 70 80 90 100
AERAVGKDIK AAYTVEEFVQ LLERPRKILV MVKAGGPVDA VINELKPLLE
110 120 130 140 150
EGDMIIDGGN SLYEDTERRT KDLEATGLGF VGMGVSGGEE GALLGPSLMP
160 170 180 190 200
GGTPAAYKEL EPILTKIAAQ VEDPDNPACV TFIGPGGAGH YVKMVHNGIE
210 220 230 240 250
YGDMQLIAEA YDILKNGLGL SNEQLHEVFG QWNQTDELNS FLIEISTDIF
260 270 280 290 300
AKKDPETGGH LIDYILDAAG QKGTGRWTVM SGLELGVPIP TIYAAVNARV
310 320 330 340 350
MSSLKEERVA ASGQLSGPSK TFSGDVEAWI PKVRDALYCS KMCSYAQGMA
360 370 380 390 400
LIAKASQEFG YDVNLPEIAR IWKGGCIIRA GFLDKIKKAF KDNPQLPNLL
410 420 430 440 450
LAPEFKQSIL DRQGPWREVL MLANEMGIAV PAFSSSLDYF DSYRRAVLPQ
460 470 480
NLTQAQRDYF GAHTYERTDK PRGEFFHTEW LD
Length:482
Mass (Da):52,874
Last modified:October 1, 1996 - v1
Checksum:iE3F982A81ABE4E68
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA10105.1.
PIRiS76127.
RefSeqiNP_442035.1. NC_000911.1.
YP_007451914.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA10105; BAA10105; BAA10105.
GeneIDi952734.
KEGGisyn:sll0329.
PATRICi23841652. VBISynSp132158_2374.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA10105.1 .
PIRi S76127.
RefSeqi NP_442035.1. NC_000911.1.
YP_007451914.1. NC_020286.1.

3D structure databases

ProteinModelPortali P52208.
SMRi P52208. Positions 8-482.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 1148.sll0329.

Proteomic databases

PaxDbi P52208.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA10105 ; BAA10105 ; BAA10105 .
GeneIDi 952734.
KEGGi syn:sll0329.
PATRICi 23841652. VBISynSp132158_2374.

Phylogenomic databases

eggNOGi COG0362.
HOGENOMi HOG000255147.
InParanoidi P52208.
KOi K00033.
OMAi DKDGVFH.
OrthoDBi EOG6MSS4W.
PhylomeDBi P52208.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00410 .
BioCyci SSP1148:GJOT-2172-MONOMER.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000109. 6PGD. 1 hit.
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR00873. gnd. 1 hit.
PROSITEi PS00461. 6PGD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome."
    Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S.
    DNA Res. 2:153-166(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27184 / PCC 6803 / N-1.
  2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry namei6PGD_SYNY3
AccessioniPrimary (citable) accession number: P52208
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 26, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3