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P52208

- 6PGD_SYNY3

UniProt

P52208 - 6PGD_SYNY3

Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene

gnd

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.By similarity

    Catalytic activityi

    6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei110 – 1101NADPBy similarity
    Binding sitei110 – 1101SubstrateBy similarity
    Active sitei193 – 1931Proton acceptorBy similarity
    Active sitei200 – 2001Proton donorBy similarity
    Binding sitei201 – 2011SubstrateBy similarity
    Binding sitei272 – 2721Substrate; via amide nitrogenBy similarity
    Binding sitei299 – 2991SubstrateBy similarity
    Binding sitei457 – 4571Substrate; shared with dimeric partnerBy similarity
    Binding sitei463 – 4631Substrate; shared with dimeric partnerBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi17 – 226NADPBy similarity
    Nucleotide bindingi40 – 423NADPBy similarity
    Nucleotide bindingi82 – 843NADPBy similarity

    GO - Molecular functioni

    1. NADP binding Source: InterPro
    2. phosphogluconate dehydrogenase (decarboxylating) activity Source: UniProtKB-EC

    GO - Biological processi

    1. D-gluconate metabolic process Source: UniProtKB-KW
    2. pentose-phosphate shunt Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Gluconate utilization, Pentose shunt

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciSSP1148:GJOT-2172-MONOMER.
    UniPathwayiUPA00115; UER00410.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    6-phosphogluconate dehydrogenase, decarboxylating (EC:1.1.1.44)
    Gene namesi
    Name:gnd
    Ordered Locus Names:sll0329
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4824826-phosphogluconate dehydrogenase, decarboxylatingPRO_0000090061Add
    BLAST

    Proteomic databases

    PaxDbiP52208.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi1148.sll0329.

    Structurei

    3D structure databases

    ProteinModelPortaliP52208.
    SMRiP52208. Positions 8-482.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni136 – 1383Substrate bindingBy similarity
    Regioni196 – 1972Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0362.
    HOGENOMiHOG000255147.
    KOiK00033.
    OMAiDKDGVFH.
    OrthoDBiEOG6MSS4W.
    PhylomeDBiP52208.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    1.20.5.320. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR006114. 6PGDH_C.
    IPR006113. 6PGDH_decarbox.
    IPR006115. 6PGDH_NADP-bd.
    IPR006184. 6PGdom_BS.
    IPR013328. DH_multihelical.
    IPR012284. Fibritin/6PGD_C-extension.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00393. 6PGD. 1 hit.
    PF03446. NAD_binding_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000109. 6PGD. 1 hit.
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR00873. gnd. 1 hit.
    PROSITEiPS00461. 6PGD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P52208-1 [UniParc]FASTAAdd to Basket

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    MQFNVAIMTK RTFGVIGLAV MGENLALNVE SRGFPIAVFN RSPNKTEKFM    50
    AERAVGKDIK AAYTVEEFVQ LLERPRKILV MVKAGGPVDA VINELKPLLE 100
    EGDMIIDGGN SLYEDTERRT KDLEATGLGF VGMGVSGGEE GALLGPSLMP 150
    GGTPAAYKEL EPILTKIAAQ VEDPDNPACV TFIGPGGAGH YVKMVHNGIE 200
    YGDMQLIAEA YDILKNGLGL SNEQLHEVFG QWNQTDELNS FLIEISTDIF 250
    AKKDPETGGH LIDYILDAAG QKGTGRWTVM SGLELGVPIP TIYAAVNARV 300
    MSSLKEERVA ASGQLSGPSK TFSGDVEAWI PKVRDALYCS KMCSYAQGMA 350
    LIAKASQEFG YDVNLPEIAR IWKGGCIIRA GFLDKIKKAF KDNPQLPNLL 400
    LAPEFKQSIL DRQGPWREVL MLANEMGIAV PAFSSSLDYF DSYRRAVLPQ 450
    NLTQAQRDYF GAHTYERTDK PRGEFFHTEW LD 482
    Length:482
    Mass (Da):52,874
    Last modified:October 1, 1996 - v1
    Checksum:iE3F982A81ABE4E68
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA10105.1.
    PIRiS76127.
    RefSeqiNP_442035.1. NC_000911.1.
    YP_007451914.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA10105; BAA10105; BAA10105.
    GeneIDi952734.
    KEGGisyn:sll0329.
    syz:MYO_121610.
    PATRICi23841652. VBISynSp132158_2374.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA10105.1 .
    PIRi S76127.
    RefSeqi NP_442035.1. NC_000911.1.
    YP_007451914.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali P52208.
    SMRi P52208. Positions 8-482.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 1148.sll0329.

    Proteomic databases

    PaxDbi P52208.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA10105 ; BAA10105 ; BAA10105 .
    GeneIDi 952734.
    KEGGi syn:sll0329.
    syz:MYO_121610.
    PATRICi 23841652. VBISynSp132158_2374.

    Phylogenomic databases

    eggNOGi COG0362.
    HOGENOMi HOG000255147.
    KOi K00033.
    OMAi DKDGVFH.
    OrthoDBi EOG6MSS4W.
    PhylomeDBi P52208.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00410 .
    BioCyci SSP1148:GJOT-2172-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    1.20.5.320. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR006114. 6PGDH_C.
    IPR006113. 6PGDH_decarbox.
    IPR006115. 6PGDH_NADP-bd.
    IPR006184. 6PGdom_BS.
    IPR013328. DH_multihelical.
    IPR012284. Fibritin/6PGD_C-extension.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00393. 6PGD. 1 hit.
    PF03446. NAD_binding_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000109. 6PGD. 1 hit.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR00873. gnd. 1 hit.
    PROSITEi PS00461. 6PGD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome."
      Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S.
      DNA Res. 2:153-166(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27184 / PCC 6803 / N-1.
    2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry namei6PGD_SYNY3
    AccessioniPrimary (citable) accession number: P52208
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3