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P52208 (6PGD_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating
EC=1.1.1.44
Gene names
Name:gnd
Ordered Locus Names:sll0329
OrganismSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifier1111708 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Chroococcales › Synechocystis

Protein attributes

Sequence length482 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity.

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4824826-phosphogluconate dehydrogenase, decarboxylating
PRO_0000090061

Regions

Nucleotide binding17 – 226NADP By similarity
Nucleotide binding40 – 423NADP By similarity
Nucleotide binding82 – 843NADP By similarity
Region136 – 1383Substrate binding By similarity
Region196 – 1972Substrate binding By similarity

Sites

Active site1931Proton acceptor By similarity
Active site2001Proton donor By similarity
Binding site1101NADP By similarity
Binding site1101Substrate By similarity
Binding site2011Substrate By similarity
Binding site2721Substrate; via amide nitrogen By similarity
Binding site2991Substrate By similarity
Binding site4571Substrate; shared with dimeric partner By similarity
Binding site4631Substrate; shared with dimeric partner By similarity

Sequences

Sequence LengthMass (Da)Tools
P52208 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: E3F982A81ABE4E68

FASTA48252,874
        10         20         30         40         50         60 
MQFNVAIMTK RTFGVIGLAV MGENLALNVE SRGFPIAVFN RSPNKTEKFM AERAVGKDIK 

        70         80         90        100        110        120 
AAYTVEEFVQ LLERPRKILV MVKAGGPVDA VINELKPLLE EGDMIIDGGN SLYEDTERRT 

       130        140        150        160        170        180 
KDLEATGLGF VGMGVSGGEE GALLGPSLMP GGTPAAYKEL EPILTKIAAQ VEDPDNPACV 

       190        200        210        220        230        240 
TFIGPGGAGH YVKMVHNGIE YGDMQLIAEA YDILKNGLGL SNEQLHEVFG QWNQTDELNS 

       250        260        270        280        290        300 
FLIEISTDIF AKKDPETGGH LIDYILDAAG QKGTGRWTVM SGLELGVPIP TIYAAVNARV 

       310        320        330        340        350        360 
MSSLKEERVA ASGQLSGPSK TFSGDVEAWI PKVRDALYCS KMCSYAQGMA LIAKASQEFG 

       370        380        390        400        410        420 
YDVNLPEIAR IWKGGCIIRA GFLDKIKKAF KDNPQLPNLL LAPEFKQSIL DRQGPWREVL 

       430        440        450        460        470        480 
MLANEMGIAV PAFSSSLDYF DSYRRAVLPQ NLTQAQRDYF GAHTYERTDK PRGEFFHTEW 


LD

« Hide

References

[1]"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome."
Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S.
DNA Res. 2:153-166(1995) [PubMed: 8590279] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 27184 / PCC 6803 / N-1.
[2]"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. expand/collapse author list , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 27184 / PCC 6803 / N-1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000022 Genomic DNA. Translation: BAA10105.1.
PIRS76127.
RefSeqNP_442035.1. NC_000911.1.

3D structure databases

ProteinModelPortalP52208.
SMRP52208. Positions 8-482.
ModBaseSearch...

Protein-protein interaction databases

STRINGP52208.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID952734.
GenomeReviewsGene locus sll0329 in contig BA000022_GR.
KEGGsyn:sll0329.
NMPDRfig|1148.1.peg.2136.
PATRIC23841652. VBISynSp132158_2374.

Phylogenomic databases

eggNOGCOG0362.
HOGENOMHBG286913.
OMASNYPDTN.
PhylomeDBP52208.
ProtClustDBPRK09287.

Enzyme and pathway databases

BioCycSSP1148:SLL0329-MONOMER.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00033.
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00873. Gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry name6PGD_SYNY3
AccessionPrimary (citable) accession number: P52208
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: January 25, 2012
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Synechocystis PCC 6803

Synechocystis (strain PCC 6803): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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