Reviewed, UniProtKB/Swiss-Prot P52208 (6PGD_SYNY3)

Names and origin

Protein names

Recommended name:
    6-phosphogluconate dehydrogenase, decarboxylating
    EC=1.1.1.44

Gene names

Name:	gnd
Ordered Locus Names:	sll0329

Organism

Synechocystis sp. (strain PCC 6803) [Complete proteome] [HAMAP]

Taxonomic identifier

1148 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechocystis

Protein attributes

Sequence length	482 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO(2) + NADPH.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.
Sequence similarities	Belongs to the 6-phosphogluconate dehydrogenase family.

Ontologies

Keywords
Biological process	Gluconate utilization Pentose shunt
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	D-gluconate metabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pentose-phosphate shunt Inferred from electronic annotation. Source: InterPro
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro phosphogluconate dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 482	482	6-phosphogluconate dehydrogenase, decarboxylating		PRO_0000090061

Sequences

	Sequence		Length	Mass (Da)
	P52208-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: E3F982A81ABE4E68	FASTA	482	52,874
	10 20 30 40 50 60 MQFNVAIMTK RTFGVIGLAV MGENLALNVE SRGFPIAVFN RSPNKTEKFM AERAVGKDIK 70 80 90 100 110 120 AAYTVEEFVQ LLERPRKILV MVKAGGPVDA VINELKPLLE EGDMIIDGGN SLYEDTERRT 130 140 150 160 170 180 KDLEATGLGF VGMGVSGGEE GALLGPSLMP GGTPAAYKEL EPILTKIAAQ VEDPDNPACV 190 200 210 220 230 240 TFIGPGGAGH YVKMVHNGIE YGDMQLIAEA YDILKNGLGL SNEQLHEVFG QWNQTDELNS 250 260 270 280 290 300 FLIEISTDIF AKKDPETGGH LIDYILDAAG QKGTGRWTVM SGLELGVPIP TIYAAVNARV 310 320 330 340 350 360 MSSLKEERVA ASGQLSGPSK TFSGDVEAWI PKVRDALYCS KMCSYAQGMA LIAKASQEFG 370 380 390 400 410 420 YDVNLPEIAR IWKGGCIIRA GFLDKIKKAF KDNPQLPNLL LAPEFKQSIL DRQGPWREVL 430 440 450 460 470 480 MLANEMGIAV PAFSSSLDYF DSYRRAVLPQ NLTQAQRDYF GAHTYERTDK PRGEFFHTEW LD

References

[1]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome." Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S. DNA Res. 2:153-166(1995) [PubMed: 8590279] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000022 Genomic DNA. Translation: BAA10105.1.
PIR	S76127.
RefSeq	NP_442035.1.
3D structure databases
HSSP	HSSP built from PDB template 2PGD based on UniProtKB P00349.
ModBase	Search...
Genome annotation databases
GeneID	952734.
GenomeReviews	Gene locus sll0329 in contig BA000022_GR.
KEGG	syn:sll0329.
NMPDR	fig|1148.1.peg.2136.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P52208.
Enzyme and pathway databases
BioCyc	SSP1148:SLL0329-MON.
Family and domain databases
InterPro	IPR006183. 6-phosphogluconate_DHase. IPR006114. 6PGDH_C. IPR006113. 6PGDH_decarbox. IPR006115. 6PGDH_NAD-bd. IPR006184. 6PGdom_BS. IPR013328. DHase_multihelical. IPR012284. Fibritin/6PGD_C-extension. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF00393. 6PGD. 1 hit. PF03446. NAD_binding_2. 1 hit. [Graphical view]
PRINTS	PR00076. 6PGDHDRGNASE.
TIGRFAMs	TIGR00873. gnd. 1 hit.
PROSITE	PS00461. 6PGD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

6PGD_SYNY3

Accession

Primary (citable) accession number: P52208

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	November 25, 2008
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)