ID   6PGD_BACLI              Reviewed;         467 AA.
AC   P52207;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   16-JUN-2009, entry version 52.
DE   RecName: Full=6-phosphogluconate dehydrogenase, decarboxylating;
DE            EC=1.1.1.44;
GN   Name=gntZ;
OS   Bacillus licheniformis.
OC   Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=1402;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=BGSC5A2;
RX   MEDLINE=96051988; PubMed=8535972; DOI=10.1093/dnares/1.4.157;
RA   Yoshida K., Seki S., Fujita Y.;
RT   "Nucleotide sequence and features of the Bacillus licheniformis gnt
RT   operon.";
RL   DNA Res. 1:157-162(1994).
CC   -!- CATALYTIC ACTIVITY: 6-phospho-D-gluconate + NADP(+) = D-ribulose
CC       5-phosphate + CO(2) + NADPH.
CC   -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC       ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage):
CC       step 3/3.
CC   -!- SIMILARITY: Belongs to the 6-phosphogluconate dehydrogenase
CC       family.
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DR   EMBL; D31631; BAA06504.1; -; Genomic_DNA.
DR   PIR; JC2306; JC2306.
DR   HSSP; P00349; 2PGD.
DR   BRENDA; 1.1.1.44; 1017.
DR   GO; GO:0050661; F:NADP or NADPH binding; IEA:InterPro.
DR   GO; GO:0004616; F:phosphogluconate dehydrogenase (decarboxyla...; IEA:EC.
DR   GO; GO:0019521; P:D-gluconate metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006098; P:pentose-phosphate shunt; IEA:UniProtKB-KW.
DR   InterPro; IPR006183; 6-phosphogluconate_DH.
DR   InterPro; IPR006114; 6PGDH_C.
DR   InterPro; IPR006113; 6PGDH_decarbox.
DR   InterPro; IPR006115; 6PGDH_NAD-bd.
DR   InterPro; IPR006184; 6PGdom_BS.
DR   InterPro; IPR013328; DH_multihelical.
DR   InterPro; IPR012284; Fibritin/6PGD_C-extension.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:1.20.5.320; Fibritin/6PGD_C-extension; 1.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Gene3D; G3DSA:1.10.1040.10; Opine_DH; 1.
DR   Pfam; PF00393; 6PGD; 1.
DR   Pfam; PF03446; NAD_binding_2; 1.
DR   PRINTS; PR00076; 6PGDHDRGNASE.
DR   TIGRFAMs; TIGR00873; gnd; 1.
DR   PROSITE; PS00461; 6PGD; 1.
PE   3: Inferred from homology;
KW   Gluconate utilization; NADP; Oxidoreductase; Pentose shunt.
FT   CHAIN         1    467       6-phosphogluconate dehydrogenase,
FT                                decarboxylating.
FT                                /FTId=PRO_0000090025.
SQ   SEQUENCE   467 AA;  51642 MW;  3F14CFF0320D8E52 CRC64;
     MRNTIGVIGL GVMGSNIALN MASKGEQVAV YNYTRDLTDQ LVQKTGGQTV KPYYELEDFV
     QSLEKPRKIF LMVTAGKPVD SVIDSLVPLL EEGDVIMDGG NSHYEDTERR YDSLKAKGIG
     YLGIGISGGE VGALKGPSIM PGGDRDVYEK AAPILTKIAA QVEGDPCCVY IGPKGAGHFV
     KMVHNGIEYA DMQLIAEAYT FLREKLLLPI DEIADIFDTW NQGELKSYLI EITAEILRKK
     DERTGAPLID VILDKTGQKG TGKWTSLQAI DNGIPSSIIT ESLFARYLSS LKDERTAAEN
     VLAGPETEER PLDQNVWIDR VRQALYMGKV CAYAQGFAQY KMTSDLNGWH LPLKDIALIF
     RGGCIIRAQF LNLISEVYDK QPDLSNLLVA PDFAEKLKEY QSGLRKVVCE GISSGISFPC
     LSTALSYYDG YRTGRSNANL LQAQANYFGA HTYERTDMEG VFHTDWY
//