Reviewed, UniProtKB/Swiss-Prot P52207 (6PGD_BACLI)

Names and origin

Protein names

Recommended name:
    6-phosphogluconate dehydrogenase, decarboxylating
    EC=1.1.1.44

Gene names

Name:

gntZ

Organism

Bacillus licheniformis

Taxonomic identifier

1402 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	467 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.
Sequence similarities	Belongs to the 6-phosphogluconate dehydrogenase family.

Ontologies

Keywords
Biological process	Gluconate utilization Pentose shunt
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	D-gluconate metabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pentose-phosphate shunt Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP or NADPH binding Inferred from electronic annotation. Source: InterPro phosphogluconate dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 467	467	6-phosphogluconate dehydrogenase, decarboxylating		PRO_0000090025

Sequences

	Sequence		Length	Mass (Da)
	P52207-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 3F14CFF0320D8E52	FASTA	467	51,642
	10 20 30 40 50 60 MRNTIGVIGL GVMGSNIALN MASKGEQVAV YNYTRDLTDQ LVQKTGGQTV KPYYELEDFV 70 80 90 100 110 120 QSLEKPRKIF LMVTAGKPVD SVIDSLVPLL EEGDVIMDGG NSHYEDTERR YDSLKAKGIG 130 140 150 160 170 180 YLGIGISGGE VGALKGPSIM PGGDRDVYEK AAPILTKIAA QVEGDPCCVY IGPKGAGHFV 190 200 210 220 230 240 KMVHNGIEYA DMQLIAEAYT FLREKLLLPI DEIADIFDTW NQGELKSYLI EITAEILRKK 250 260 270 280 290 300 DERTGAPLID VILDKTGQKG TGKWTSLQAI DNGIPSSIIT ESLFARYLSS LKDERTAAEN 310 320 330 340 350 360 VLAGPETEER PLDQNVWIDR VRQALYMGKV CAYAQGFAQY KMTSDLNGWH LPLKDIALIF 370 380 390 400 410 420 RGGCIIRAQF LNLISEVYDK QPDLSNLLVA PDFAEKLKEY QSGLRKVVCE GISSGISFPC 430 440 450 460 LSTALSYYDG YRTGRSNANL LQAQANYFGA HTYERTDMEG VFHTDWY

References

[1]	"Nucleotide sequence and features of the Bacillus licheniformis gnt operon." Yoshida K., Seki S., Fujita Y. DNA Res. 1:157-162(1994) [PubMed: 8535972] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: BGSC5A2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D31631 Genomic DNA. Translation: BAA06504.1.
PIR	JC2306.
3D structure databases
HSSP	HSSP built from PDB template 2PGD based on UniProtKB P00349.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.1.1.44. 1017.
Family and domain databases
InterPro	IPR006183. 6-phosphogluconate_DH. IPR006114. 6PGDH_C. IPR006113. 6PGDH_decarbox. IPR006115. 6PGDH_NAD-bd. IPR006184. 6PGdom_BS. IPR013328. DH_multihelical. IPR012284. Fibritin/6PGD_C-extension. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF00393. 6PGD. 1 hit. PF03446. NAD_binding_2. 1 hit. [Graphical view]
PRINTS	PR00076. 6PGDHDRGNASE.
TIGRFAMs	TIGR00873. gnd. 1 hit.
PROSITE	PS00461. 6PGD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

6PGD_BACLI

Accession

Primary (citable) accession number: P52207

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	June 16, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)