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P52207

- 6PGD_BACLI

UniProt

P52207 - 6PGD_BACLI

Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene

gntZ

Organism
Bacillus licheniformis
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.By similarity

    Catalytic activityi

    6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei101 – 1011NADPBy similarity
    Binding sitei101 – 1011SubstrateBy similarity
    Active sitei181 – 1811Proton acceptorBy similarity
    Active sitei188 – 1881Proton donorBy similarity
    Binding sitei189 – 1891SubstrateBy similarity
    Binding sitei259 – 2591Substrate; via amide nitrogenBy similarity
    Binding sitei286 – 2861SubstrateBy similarity
    Binding sitei451 – 4511Substrate; shared with dimeric partnerBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi9 – 146NADPBy similarity
    Nucleotide bindingi32 – 343NADPBy similarity
    Nucleotide bindingi73 – 753NADPBy similarity

    GO - Molecular functioni

    1. NADP binding Source: InterPro
    2. phosphogluconate dehydrogenase (decarboxylating) activity Source: UniProtKB-EC

    GO - Biological processi

    1. D-gluconate metabolic process Source: UniProtKB-KW
    2. pentose-phosphate shunt Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Gluconate utilization, Pentose shunt

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00115; UER00410.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    6-phosphogluconate dehydrogenase, decarboxylating (EC:1.1.1.44)
    Gene namesi
    Name:gntZ
    OrganismiBacillus licheniformis
    Taxonomic identifieri1402 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4674676-phosphogluconate dehydrogenase, decarboxylatingPRO_0000090025Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP52207.
    SMRiP52207. Positions 3-467.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni127 – 1293Substrate bindingBy similarity
    Regioni184 – 1852Substrate bindingBy similarity

    Sequence similaritiesi

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    1.20.5.320. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR006114. 6PGDH_C.
    IPR006113. 6PGDH_decarbox.
    IPR006115. 6PGDH_NADP-bd.
    IPR006184. 6PGdom_BS.
    IPR013328. DH_multihelical.
    IPR012284. Fibritin/6PGD_C-extension.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00393. 6PGD. 1 hit.
    PF03446. NAD_binding_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000109. 6PGD. 1 hit.
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR00873. gnd. 1 hit.
    PROSITEiPS00461. 6PGD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P52207-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRNTIGVIGL GVMGSNIALN MASKGEQVAV YNYTRDLTDQ LVQKTGGQTV    50
    KPYYELEDFV QSLEKPRKIF LMVTAGKPVD SVIDSLVPLL EEGDVIMDGG 100
    NSHYEDTERR YDSLKAKGIG YLGIGISGGE VGALKGPSIM PGGDRDVYEK 150
    AAPILTKIAA QVEGDPCCVY IGPKGAGHFV KMVHNGIEYA DMQLIAEAYT 200
    FLREKLLLPI DEIADIFDTW NQGELKSYLI EITAEILRKK DERTGAPLID 250
    VILDKTGQKG TGKWTSLQAI DNGIPSSIIT ESLFARYLSS LKDERTAAEN 300
    VLAGPETEER PLDQNVWIDR VRQALYMGKV CAYAQGFAQY KMTSDLNGWH 350
    LPLKDIALIF RGGCIIRAQF LNLISEVYDK QPDLSNLLVA PDFAEKLKEY 400
    QSGLRKVVCE GISSGISFPC LSTALSYYDG YRTGRSNANL LQAQANYFGA 450
    HTYERTDMEG VFHTDWY 467
    Length:467
    Mass (Da):51,642
    Last modified:October 1, 1996 - v1
    Checksum:i3F14CFF0320D8E52
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D31631 Genomic DNA. Translation: BAA06504.1.
    PIRiJC2306.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D31631 Genomic DNA. Translation: BAA06504.1 .
    PIRi JC2306.

    3D structure databases

    ProteinModelPortali P52207.
    SMRi P52207. Positions 3-467.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00410 .

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    1.20.5.320. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR006114. 6PGDH_C.
    IPR006113. 6PGDH_decarbox.
    IPR006115. 6PGDH_NADP-bd.
    IPR006184. 6PGdom_BS.
    IPR013328. DH_multihelical.
    IPR012284. Fibritin/6PGD_C-extension.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00393. 6PGD. 1 hit.
    PF03446. NAD_binding_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000109. 6PGD. 1 hit.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR00873. gnd. 1 hit.
    PROSITEi PS00461. 6PGD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence and features of the Bacillus licheniformis gnt operon."
      Yoshida K., Seki S., Fujita Y.
      DNA Res. 1:157-162(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: BGSC5A2.

    Entry informationi

    Entry namei6PGD_BACLI
    AccessioniPrimary (citable) accession number: P52207
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3