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P52203 (CCL2_CANFA) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 2
Alternative name(s):
Monocyte chemoattractant protein 1
Monocyte chemotactic protein 1
Short name=MCP-1
Small-inducible cytokine A2
Gene names
Name:CCL2
Synonyms:MCP1, SCYA2
OrganismCanis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Protein attributes

Sequence length101 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Chemotactic factor that attracts monocytes, but not neutrophils. Important factor in the course of the inflammatory reaction to reperfusion of the previously ischemic myocardium. May play a significant role in monocyte trafficking into the reperfused myocardium.

Subunit structure

Monomer or homodimer; in equilibrium By similarity.

Subcellular location

Secreted.

Tissue specificity

Endothelium of small veins and intrafascicular veins, and infiltrating leukocytes.

Induction

By TNF-alpha.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
   Biological processChemotaxis
Inflammatory response
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
Pyrrolidone carboxylic acid
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell chemotaxis

Inferred from electronic annotation. Source: GOC

immune response

Inferred from electronic annotation. Source: InterPro

inflammatory response

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

membrane

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 By similarity
Chain24 – 10178C-C motif chemokine 2
PRO_0000005143

Amino acid modifications

Modified residue241Pyrrolidone carboxylic acid By similarity
Disulfide bond34 ↔ 59 By similarity
Disulfide bond35 ↔ 75 By similarity

Sequences

Sequence LengthMass (Da)Tools
P52203 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: CDD7E2B1901A7267

FASTA10111,121
        10         20         30         40         50         60 
MKVSAALLCL LLIAAALTTQ VLTQPDAIIS PVTCCYTLTN KKISIQRLAS YKRVTSSKCP 

        70         80         90        100 
KEAVIFKTVL NKEICADPKQ KWVQDSMAHL DKKSQTQTAK P 

« Hide

References

[1]"Induction of monocyte chemoattractant protein-1 in the small veins of the ischemic and reperfused canine myocardium."
Kumar A.G., Ballantyne C.M., Michael L.H., Kukielka G.L., Youker K.A., Lindsey M.L., Hawkins H.K., Birdsall H.H., Mackay C.R., Larosa G.J., Rossen R.D., Smith C.W., Entman M.L.
Circulation 95:693-700(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Jugular vein endothelial cell.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U29653 mRNA. Translation: AAA84911.1.
RefSeqNP_001003297.1. NM_001003297.1.
UniGeneCfa.3851.

3D structure databases

ProteinModelPortalP52203.
SMRP52203. Positions 24-96.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9615.ENSCAFP00000027107.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID403981.
KEGGcfa:403981.

Organism-specific databases

CTD6347.

Phylogenomic databases

eggNOGNOG46819.
HOGENOMHOG000036686.
HOVERGENHBG017871.
InParanoidP52203.
KOK14624.

Family and domain databases

InterProIPR000827. Chemokine_CC_CS.
IPR008097. Chemokine_CX3CL1.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
PRINTSPR01721. FRACTALKINE.
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20817471.

Entry information

Entry nameCCL2_CANFA
AccessionPrimary (citable) accession number: P52203
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 19, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families