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P52203

- CCL2_CANFA

UniProt

P52203 - CCL2_CANFA

Protein

C-C motif chemokine 2

Gene

CCL2

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Chemotactic factor that attracts monocytes, but not neutrophils. Important factor in the course of the inflammatory reaction to reperfusion of the previously ischemic myocardium. May play a significant role in monocyte trafficking into the reperfused myocardium.

    GO - Biological processi

    1. cell chemotaxis Source: GOC
    2. immune response Source: InterPro
    3. inflammatory response Source: UniProtKB-KW

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 2
    Alternative name(s):
    Monocyte chemoattractant protein 1
    Monocyte chemotactic protein 1
    Short name:
    MCP-1
    Small-inducible cytokine A2
    Gene namesi
    Name:CCL2
    Synonyms:MCP1, SCYA2
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW
    2. membrane Source: InterPro

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323By similarityAdd
    BLAST
    Chaini24 – 10178C-C motif chemokine 2PRO_0000005143Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei24 – 241Pyrrolidone carboxylic acidBy similarity
    Disulfide bondi34 ↔ 59By similarity
    Disulfide bondi35 ↔ 75By similarity

    Keywords - PTMi

    Disulfide bond, Pyrrolidone carboxylic acid

    Expressioni

    Tissue specificityi

    Endothelium of small veins and intrafascicular veins, and infiltrating leukocytes.

    Inductioni

    By TNF-alpha.

    Interactioni

    Subunit structurei

    Monomer or homodimer; in equilibrium.By similarity

    Protein-protein interaction databases

    STRINGi9615.ENSCAFP00000027107.

    Structurei

    3D structure databases

    ProteinModelPortaliP52203.
    SMRiP52203. Positions 24-96.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG46819.
    HOGENOMiHOG000036686.
    HOVERGENiHBG017871.
    InParanoidiP52203.
    KOiK14624.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR008097. Chemokine_CX3CL1.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    PRINTSiPR01721. FRACTALKINE.
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P52203-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVSAALLCL LLIAAALTTQ VLTQPDAIIS PVTCCYTLTN KKISIQRLAS    50
    YKRVTSSKCP KEAVIFKTVL NKEICADPKQ KWVQDSMAHL DKKSQTQTAK 100
    P 101
    Length:101
    Mass (Da):11,121
    Last modified:October 1, 1996 - v1
    Checksum:iCDD7E2B1901A7267
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U29653 mRNA. Translation: AAA84911.1.
    RefSeqiNP_001003297.1. NM_001003297.1.
    UniGeneiCfa.3851.

    Genome annotation databases

    GeneIDi403981.
    KEGGicfa:403981.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U29653 mRNA. Translation: AAA84911.1 .
    RefSeqi NP_001003297.1. NM_001003297.1.
    UniGenei Cfa.3851.

    3D structure databases

    ProteinModelPortali P52203.
    SMRi P52203. Positions 24-96.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9615.ENSCAFP00000027107.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 403981.
    KEGGi cfa:403981.

    Organism-specific databases

    CTDi 6347.

    Phylogenomic databases

    eggNOGi NOG46819.
    HOGENOMi HOG000036686.
    HOVERGENi HBG017871.
    InParanoidi P52203.
    KOi K14624.

    Miscellaneous databases

    NextBioi 20817471.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR008097. Chemokine_CX3CL1.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    PRINTSi PR01721. FRACTALKINE.
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Induction of monocyte chemoattractant protein-1 in the small veins of the ischemic and reperfused canine myocardium."
      Kumar A.G., Ballantyne C.M., Michael L.H., Kukielka G.L., Youker K.A., Lindsey M.L., Hawkins H.K., Birdsall H.H., Mackay C.R., Larosa G.J., Rossen R.D., Smith C.W., Entman M.L.
      Circulation 95:693-700(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Jugular vein endothelial cell.

    Entry informationi

    Entry nameiCCL2_CANFA
    AccessioniPrimary (citable) accession number: P52203
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3