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P52198

- RND2_HUMAN

UniProt

P52198 - RND2_HUMAN

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Protein

Rho-related GTP-binding protein RhoN

Gene

RND2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May be specifically involved in neuronal and hepatic functions. Is a C3 toxin-insensitive member of the Rho subfamily (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi14 – 218GTPBy similarity
Nucleotide bindingi61 – 655GTPBy similarity
Nucleotide bindingi119 – 1224GTPBy similarity

GO - Molecular functioni

  1. GTPase activity Source: ProtInc
  2. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. GTP catabolic process Source: GOC
  2. positive regulation of collateral sprouting Source: Ensembl
  3. signal transduction Source: ProtInc
  4. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Rho-related GTP-binding protein RhoN
Alternative name(s):
Rho family GTPase 2
Rho-related GTP-binding protein Rho7
Rnd2
Gene namesi
Name:RND2
Synonyms:ARHN, RHO7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:18315. RND2.

Subcellular locationi

Cytoplasmic vesiclesecretory vesicleacrosome membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated
Note: Colocalizes with RACGAP1 in Golgi-derived proacrosomal vesicles and the acrosome.1 Publication

GO - Cellular componenti

  1. cytoplasmic vesicle Source: UniProtKB-KW
  2. early endosome Source: Ensembl
  3. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134936989.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224Rho-related GTP-binding protein RhoNPRO_0000198876Add
BLAST
Propeptidei225 – 2273Removed in mature formBy similarityPRO_0000281228

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei224 – 2241Cysteine methyl esterBy similarity
Lipidationi224 – 2241S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP52198.
PRIDEiP52198.

PTM databases

PhosphoSiteiP52198.

Expressioni

Tissue specificityi

Highly expressed in testis.

Gene expression databases

BgeeiP52198.
CleanExiHS_RND2.
ExpressionAtlasiP52198. baseline and differential.
GenevestigatoriP52198.

Interactioni

Subunit structurei

Interacts with the Rho-GAP domain of RACGAP1. Interacts with UBXD5.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Fnbp1Q8R5112EBI-1111436,EBI-1111424From a different organism.

Protein-protein interaction databases

BioGridi113810. 8 interactions.
IntActiP52198. 1 interaction.
MINTiMINT-257912.
STRINGi9606.ENSP00000225973.

Structurei

3D structure databases

ProteinModelPortaliP52198.
SMRiP52198. Positions 7-184.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi36 – 449Effector regionSequence Analysis

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00760000119020.
HOGENOMiHOG000233974.
HOVERGENiHBG009351.
InParanoidiP52198.
KOiK07858.
OrthoDBiEOG71P2BH.
PhylomeDBiP52198.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00174. RHO. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52198-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEGQSGRCKI VVVGDAECGK TALLQVFAKD AYPGSYVPTV FENYTASFEI
60 70 80 90 100
DKRRIELNMW DTSGSSYYDN VRPLAYPDSD AVLICFDISR PETLDSVLKK
110 120 130 140 150
WQGETQEFCP NAKVVLVGCK LDMRTDLATL RELSKQRLIP VTHEQGTVLA
160 170 180 190 200
KQVGAVSYVE CSSRSSERSV RDVFHVATVA SLGRGHRQLR RTDSRRGMQR
210 220
SAQLSGRPDR GNEGEIHKDR AKSCNLM
Length:227
Mass (Da):25,369
Last modified:November 1, 1997 - v2
Checksum:iDB2127B97B468F86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95456 mRNA. Translation: CAA64726.1.
L78833 Genomic DNA. Translation: AAC37595.1.
AF498968 mRNA. Translation: AAM21115.1.
BT019394 mRNA. Translation: AAV38201.1.
AK290199 mRNA. Translation: BAF82888.1.
CH471152 Genomic DNA. Translation: EAW60920.1.
BC094842 mRNA. Translation: AAH94842.1.
BC104986 mRNA. Translation: AAI04987.1.
BC104990 mRNA. Translation: AAI04991.1.
CCDSiCCDS11452.1.
RefSeqiNP_005431.1. NM_005440.4.
UniGeneiHs.603111.

Genome annotation databases

EnsembliENST00000587250; ENSP00000466680; ENSG00000108830.
GeneIDi8153.
KEGGihsa:8153.
UCSCiuc002icn.3. human.

Polymorphism databases

DMDMi2507301.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95456 mRNA. Translation: CAA64726.1 .
L78833 Genomic DNA. Translation: AAC37595.1 .
AF498968 mRNA. Translation: AAM21115.1 .
BT019394 mRNA. Translation: AAV38201.1 .
AK290199 mRNA. Translation: BAF82888.1 .
CH471152 Genomic DNA. Translation: EAW60920.1 .
BC094842 mRNA. Translation: AAH94842.1 .
BC104986 mRNA. Translation: AAI04987.1 .
BC104990 mRNA. Translation: AAI04991.1 .
CCDSi CCDS11452.1.
RefSeqi NP_005431.1. NM_005440.4.
UniGenei Hs.603111.

3D structure databases

ProteinModelPortali P52198.
SMRi P52198. Positions 7-184.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113810. 8 interactions.
IntActi P52198. 1 interaction.
MINTi MINT-257912.
STRINGi 9606.ENSP00000225973.

PTM databases

PhosphoSitei P52198.

Polymorphism databases

DMDMi 2507301.

Proteomic databases

PaxDbi P52198.
PRIDEi P52198.

Protocols and materials databases

DNASUi 8153.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000587250 ; ENSP00000466680 ; ENSG00000108830 .
GeneIDi 8153.
KEGGi hsa:8153.
UCSCi uc002icn.3. human.

Organism-specific databases

CTDi 8153.
GeneCardsi GC17P041177.
HGNCi HGNC:18315. RND2.
MIMi 601555. gene.
neXtProti NX_P52198.
PharmGKBi PA134936989.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1100.
GeneTreei ENSGT00760000119020.
HOGENOMi HOG000233974.
HOVERGENi HBG009351.
InParanoidi P52198.
KOi K07858.
OrthoDBi EOG71P2BH.
PhylomeDBi P52198.

Miscellaneous databases

ChiTaRSi RND2. human.
GeneWikii Rnd2.
GenomeRNAii 8153.
NextBioi 30826.
PROi P52198.
SOURCEi Search...

Gene expression databases

Bgeei P52198.
CleanExi HS_RND2.
ExpressionAtlasi P52198. baseline and differential.
Genevestigatori P52198.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00174. RHO. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51420. RHO. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion."
    Nobes C.D., Lauritzen I., Mattei M.-G., Paris S., Hall A., Chardin P.
    J. Cell Biol. 141:187-197(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1."
    Smith T.M., Lee M.K., Szabo C.I., Jerome N., McEuen M., Taylor M., Hood L., King M.-C.
    Genome Res. 6:1029-1049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thalamus.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Ovary.
  8. "Rho family GTPase Rnd2 interacts and co-localizes with MgcRacGAP in male germ cells."
    Naud N., Toure A., Liu J., Pineau C., Morin L., Dorseuil O., Escalier D., Chardin P., Gacon G.
    Biochem. J. 372:105-112(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RACGAP1, SUBCELLULAR LOCATION.
  9. "Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers."
    Katoh H., Harada A., Mori K., Negishi M.
    Mol. Cell. Biol. 22:2952-2964(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UBXD5.

Entry informationi

Entry nameiRND2_HUMAN
AccessioniPrimary (citable) accession number: P52198
Secondary accession number(s): A8K2D4
, O00690, O00734, Q5U0P6, Q99535
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: November 26, 2014
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3