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P52198

- RND2_HUMAN

UniProt

P52198 - RND2_HUMAN

Protein

Rho-related GTP-binding protein RhoN

Gene

RND2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    May be specifically involved in neuronal and hepatic functions. Is a C3 toxin-insensitive member of the Rho subfamily By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi14 – 218GTPBy similarity
    Nucleotide bindingi61 – 655GTPBy similarity
    Nucleotide bindingi119 – 1224GTPBy similarity

    GO - Molecular functioni

    1. GTPase activity Source: ProtInc
    2. GTP binding Source: UniProtKB-KW
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. GTP catabolic process Source: GOC
    2. positive regulation of collateral sprouting Source: Ensembl
    3. signal transduction Source: ProtInc
    4. small GTPase mediated signal transduction Source: InterPro

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Rho-related GTP-binding protein RhoN
    Alternative name(s):
    Rho family GTPase 2
    Rho-related GTP-binding protein Rho7
    Rnd2
    Gene namesi
    Name:RND2
    Synonyms:ARHN, RHO7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:18315. RND2.

    Subcellular locationi

    Cytoplasmic vesiclesecretory vesicleacrosome membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated
    Note: Colocalizes with RACGAP1 in Golgi-derived proacrosomal vesicles and the acrosome.1 Publication

    GO - Cellular componenti

    1. acrosomal membrane Source: UniProtKB-SubCell
    2. early endosome Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134936989.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 224224Rho-related GTP-binding protein RhoNPRO_0000198876Add
    BLAST
    Propeptidei225 – 2273Removed in mature formBy similarityPRO_0000281228

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei224 – 2241Cysteine methyl esterBy similarity
    Lipidationi224 – 2241S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Methylation, Prenylation

    Proteomic databases

    PaxDbiP52198.
    PRIDEiP52198.

    PTM databases

    PhosphoSiteiP52198.

    Expressioni

    Tissue specificityi

    Highly expressed in testis.

    Gene expression databases

    ArrayExpressiP52198.
    BgeeiP52198.
    CleanExiHS_RND2.
    GenevestigatoriP52198.

    Interactioni

    Subunit structurei

    Interacts with the Rho-GAP domain of RACGAP1. Interacts with UBXD5.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Fnbp1Q8R5112EBI-1111436,EBI-1111424From a different organism.

    Protein-protein interaction databases

    BioGridi113810. 8 interactions.
    IntActiP52198. 1 interaction.
    MINTiMINT-257912.
    STRINGi9606.ENSP00000225973.

    Structurei

    3D structure databases

    ProteinModelPortaliP52198.
    SMRiP52198. Positions 7-184.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi36 – 449Effector regionSequence Analysis

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rho family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    HOGENOMiHOG000233974.
    HOVERGENiHBG009351.
    InParanoidiP52198.
    KOiK07858.
    OrthoDBiEOG71P2BH.
    PhylomeDBiP52198.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003578. Small_GTPase_Rho.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00174. RHO. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51420. RHO. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P52198-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEGQSGRCKI VVVGDAECGK TALLQVFAKD AYPGSYVPTV FENYTASFEI    50
    DKRRIELNMW DTSGSSYYDN VRPLAYPDSD AVLICFDISR PETLDSVLKK 100
    WQGETQEFCP NAKVVLVGCK LDMRTDLATL RELSKQRLIP VTHEQGTVLA 150
    KQVGAVSYVE CSSRSSERSV RDVFHVATVA SLGRGHRQLR RTDSRRGMQR 200
    SAQLSGRPDR GNEGEIHKDR AKSCNLM 227
    Length:227
    Mass (Da):25,369
    Last modified:November 1, 1997 - v2
    Checksum:iDB2127B97B468F86
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X95456 mRNA. Translation: CAA64726.1.
    L78833 Genomic DNA. Translation: AAC37595.1.
    AF498968 mRNA. Translation: AAM21115.1.
    BT019394 mRNA. Translation: AAV38201.1.
    AK290199 mRNA. Translation: BAF82888.1.
    CH471152 Genomic DNA. Translation: EAW60920.1.
    BC094842 mRNA. Translation: AAH94842.1.
    BC104986 mRNA. Translation: AAI04987.1.
    BC104990 mRNA. Translation: AAI04991.1.
    CCDSiCCDS11452.1.
    RefSeqiNP_005431.1. NM_005440.4.
    UniGeneiHs.603111.

    Genome annotation databases

    EnsembliENST00000587250; ENSP00000466680; ENSG00000108830.
    GeneIDi8153.
    KEGGihsa:8153.
    UCSCiuc002icn.3. human.

    Polymorphism databases

    DMDMi2507301.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X95456 mRNA. Translation: CAA64726.1 .
    L78833 Genomic DNA. Translation: AAC37595.1 .
    AF498968 mRNA. Translation: AAM21115.1 .
    BT019394 mRNA. Translation: AAV38201.1 .
    AK290199 mRNA. Translation: BAF82888.1 .
    CH471152 Genomic DNA. Translation: EAW60920.1 .
    BC094842 mRNA. Translation: AAH94842.1 .
    BC104986 mRNA. Translation: AAI04987.1 .
    BC104990 mRNA. Translation: AAI04991.1 .
    CCDSi CCDS11452.1.
    RefSeqi NP_005431.1. NM_005440.4.
    UniGenei Hs.603111.

    3D structure databases

    ProteinModelPortali P52198.
    SMRi P52198. Positions 7-184.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113810. 8 interactions.
    IntActi P52198. 1 interaction.
    MINTi MINT-257912.
    STRINGi 9606.ENSP00000225973.

    PTM databases

    PhosphoSitei P52198.

    Polymorphism databases

    DMDMi 2507301.

    Proteomic databases

    PaxDbi P52198.
    PRIDEi P52198.

    Protocols and materials databases

    DNASUi 8153.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000587250 ; ENSP00000466680 ; ENSG00000108830 .
    GeneIDi 8153.
    KEGGi hsa:8153.
    UCSCi uc002icn.3. human.

    Organism-specific databases

    CTDi 8153.
    GeneCardsi GC17P041177.
    HGNCi HGNC:18315. RND2.
    MIMi 601555. gene.
    neXtProti NX_P52198.
    PharmGKBi PA134936989.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1100.
    HOGENOMi HOG000233974.
    HOVERGENi HBG009351.
    InParanoidi P52198.
    KOi K07858.
    OrthoDBi EOG71P2BH.
    PhylomeDBi P52198.

    Miscellaneous databases

    GeneWikii Rnd2.
    GenomeRNAii 8153.
    NextBioi 30826.
    PROi P52198.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P52198.
    Bgeei P52198.
    CleanExi HS_RND2.
    Genevestigatori P52198.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003578. Small_GTPase_Rho.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00174. RHO. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51420. RHO. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion."
      Nobes C.D., Lauritzen I., Mattei M.-G., Paris S., Hall A., Chardin P.
      J. Cell Biol. 141:187-197(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1."
      Smith T.M., Lee M.K., Szabo C.I., Jerome N., McEuen M., Taylor M., Hood L., King M.-C.
      Genome Res. 6:1029-1049(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III, Ikeda S.R., Aronstam R.S.
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thalamus.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Ovary.
    8. "Rho family GTPase Rnd2 interacts and co-localizes with MgcRacGAP in male germ cells."
      Naud N., Toure A., Liu J., Pineau C., Morin L., Dorseuil O., Escalier D., Chardin P., Gacon G.
      Biochem. J. 372:105-112(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RACGAP1, SUBCELLULAR LOCATION.
    9. "Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers."
      Katoh H., Harada A., Mori K., Negishi M.
      Mol. Cell. Biol. 22:2952-2964(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH UBXD5.

    Entry informationi

    Entry nameiRND2_HUMAN
    AccessioniPrimary (citable) accession number: P52198
    Secondary accession number(s): A8K2D4
    , O00690, O00734, Q5U0P6, Q99535
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 127 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3