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P52191

- KCJ16_RAT

UniProt

P52191 - KCJ16_RAT

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Protein

Inward rectifier potassium channel 16

Gene

Kcnj16

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei161 – 1611Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumBy similarity

GO - Molecular functioni

  1. inward rectifier potassium channel activity Source: InterPro

GO - Biological processi

  1. cellular potassium ion transport Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Inward rectifier potassium channel 16
Alternative name(s):
BIR9
Inward rectifier K(+) channel Kir5.1
Potassium channel, inwardly rectifying subfamily J member 16
Gene namesi
Name:Kcnj16
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi61824. Kcnj16.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7070CytoplasmicBy similarityAdd
BLAST
Transmembranei71 – 9525Helical; Name=M1By similarityAdd
BLAST
Topological domaini96 – 11722ExtracellularBy similarityAdd
BLAST
Intramembranei118 – 12912Helical; Pore-forming; Name=H5By similarityAdd
BLAST
Intramembranei130 – 1367Pore-formingBy similarity
Topological domaini137 – 1459ExtracellularBy similarity
Transmembranei146 – 16722Helical; Name=M2By similarityAdd
BLAST
Topological domaini168 – 419252CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 419419Inward rectifier potassium channel 16PRO_0000154977Add
BLAST

PTM databases

PhosphoSiteiP52191.

Expressioni

Tissue specificityi

In the brain, testis, liver, spleen, kidney, submaxillary gland and adrenals.

Gene expression databases

GenevestigatoriP52191.

Interactioni

Subunit structurei

Seems to form heterodimer with Kir4.1/KCNJ10 or Kir2.1/KCNJ2.

Structurei

3D structure databases

ProteinModelPortaliP52191.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi131 – 1366Selectivity filterBy similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG277052.
HOGENOMiHOG000237325.
HOVERGENiHBG006178.
InParanoidiP52191.
PhylomeDBiP52191.

Family and domain databases

Gene3Di2.60.40.1400. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR008061. K_chnl_inward-rec_Kir5.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view]
PANTHERiPTHR11767. PTHR11767. 1 hit.
PTHR11767:SF24. PTHR11767:SF24. 1 hit.
PfamiPF01007. IRK. 1 hit.
[Graphical view]
PIRSFiPIRSF005465. GIRK_kir. 1 hit.
PRINTSiPR01678. KIR5CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

P52191-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSYYGSSYRI VNVDSKYPGY PPEHAIAEKR RARRRLLHKD GSCNVYFKHI
60 70 80 90 100
FGEWGSYMVD IFTTLVDTKW RHMFVVFSLS YILSWLIFGS IFWLIALHHG
110 120 130 140 150
DLLSDPDITP CVDNVHSFTA AFLFSLETQT TIGYGYRCVT EECSVAVLTV
160 170 180 190 200
ILQSILSCII NTFIIGAALA KMATARKRAQ TIRFSYFALI GMRDGKLCLM
210 220 230 240 250
WRIGDFRPNH VVEGTVRAQL LRYSEDSEGR MTMAFKDLKL VNDQIILVTP
260 270 280 290 300
VTIVHEIDHE SPLYALDRKA VAKDNFEILV TFIYTGDSTG TSHQSRSSYV
310 320 330 340 350
PREILWGHRF HDVLEVKRKY YKVNCLQFEG SVEVYAPFCS AKQLDWKDQQ
360 370 380 390 400
LNNLEKTSPA RGSCTSDTNT RRRSFSAVAM VSSCENPEET SLSPQDECKE
410
VPYQKALLTL NRISMESQM
Length:419
Mass (Da):47,936
Last modified:April 27, 2001 - v2
Checksum:iACE54A72D511A11C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti361 – 41959RGSCT…MESQM → PRILHLGHQHQEEILQRSCH GEQL in CAA58564. (PubMed:7874445)CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83581 mRNA. Translation: CAA58564.1.
AF249676 Genomic DNA. Translation: AAF74265.1.
UniGeneiRn.1989.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83581 mRNA. Translation: CAA58564.1 .
AF249676 Genomic DNA. Translation: AAF74265.1 .
UniGenei Rn.1989.

3D structure databases

ProteinModelPortali P52191.
ModBasei Search...
MobiDBi Search...

Chemistry

GuidetoPHARMACOLOGYi 440.

PTM databases

PhosphoSitei P52191.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

RGDi 61824. Kcnj16.

Phylogenomic databases

eggNOGi NOG277052.
HOGENOMi HOG000237325.
HOVERGENi HBG006178.
InParanoidi P52191.
PhylomeDBi P52191.

Miscellaneous databases

PROi P52191.

Gene expression databases

Genevestigatori P52191.

Family and domain databases

Gene3Di 2.60.40.1400. 1 hit.
InterProi IPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR008061. K_chnl_inward-rec_Kir5.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view ]
PANTHERi PTHR11767. PTHR11767. 1 hit.
PTHR11767:SF24. PTHR11767:SF24. 1 hit.
Pfami PF01007. IRK. 1 hit.
[Graphical view ]
PIRSFi PIRSF005465. GIRK_kir. 1 hit.
PRINTSi PR01678. KIR5CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMi SSF81296. SSF81296. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cloning and expression of a family of inward rectifier potassium channels."
    Bond C.T., Pessia M., Xia X.-M., Lagrutta A., Kavanaugh M.P., Adelman J.P.
    Recept. Channels 2:183-191(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.
  2. "pH dependence of the inwardly rectifying potassium channel, Kir5.1, and localization in renal tubular epithelia."
    Tucker S.J., Imbrici P., Salvatore L., D'Adamo M.C., Pessia M.
    J. Biol. Chem. 275:16404-16407(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiKCJ16_RAT
AccessioniPrimary (citable) accession number: P52191
Secondary accession number(s): Q9JI87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: April 27, 2001
Last modified: October 29, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3