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P52191

- KCJ16_RAT

UniProt

P52191 - KCJ16_RAT

Protein

Inward rectifier potassium channel 16

Gene

Kcnj16

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 2 (27 Apr 2001)
      Previous versions | rss
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    Functioni

    Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei161 – 1611Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumBy similarity

    GO - Molecular functioni

    1. inward rectifier potassium channel activity Source: InterPro
    2. protein binding Source: RGD

    GO - Biological processi

    1. cellular potassium ion transport Source: RGD

    Keywords - Molecular functioni

    Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inward rectifier potassium channel 16
    Alternative name(s):
    BIR9
    Inward rectifier K(+) channel Kir5.1
    Potassium channel, inwardly rectifying subfamily J member 16
    Gene namesi
    Name:Kcnj16
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi61824. Kcnj16.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 419419Inward rectifier potassium channel 16PRO_0000154977Add
    BLAST

    PTM databases

    PhosphoSiteiP52191.

    Expressioni

    Tissue specificityi

    In the brain, testis, liver, spleen, kidney, submaxillary gland and adrenals.

    Gene expression databases

    GenevestigatoriP52191.

    Interactioni

    Subunit structurei

    Seems to form heterodimer with Kir4.1/KCNJ10 or Kir2.1/KCNJ2.

    Structurei

    3D structure databases

    ProteinModelPortaliP52191.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7070CytoplasmicBy similarityAdd
    BLAST
    Topological domaini96 – 11722ExtracellularBy similarityAdd
    BLAST
    Topological domaini137 – 1459ExtracellularBy similarity
    Topological domaini168 – 419252CytoplasmicBy similarityAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei118 – 12912Helical; Pore-forming; Name=H5By similarityAdd
    BLAST
    Intramembranei130 – 1367Pore-formingBy similarity

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei71 – 9525Helical; Name=M1By similarityAdd
    BLAST
    Transmembranei146 – 16722Helical; Name=M2By similarityAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi131 – 1366Selectivity filterBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG277052.
    HOGENOMiHOG000237325.
    HOVERGENiHBG006178.
    InParanoidiP52191.
    PhylomeDBiP52191.

    Family and domain databases

    Gene3Di2.60.40.1400. 1 hit.
    InterProiIPR014756. Ig_E-set.
    IPR016449. K_chnl_inward-rec_Kir.
    IPR008061. K_chnl_inward-rec_Kir5.
    IPR013518. K_chnl_inward-rec_Kir_cyto.
    [Graphical view]
    PANTHERiPTHR11767. PTHR11767. 1 hit.
    PTHR11767:SF24. PTHR11767:SF24. 1 hit.
    PfamiPF01007. IRK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005465. GIRK_kir. 1 hit.
    PRINTSiPR01678. KIR5CHANNEL.
    PR01320. KIRCHANNEL.
    SUPFAMiSSF81296. SSF81296. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P52191-1 [UniParc]FASTAAdd to Basket

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    MSYYGSSYRI VNVDSKYPGY PPEHAIAEKR RARRRLLHKD GSCNVYFKHI    50
    FGEWGSYMVD IFTTLVDTKW RHMFVVFSLS YILSWLIFGS IFWLIALHHG 100
    DLLSDPDITP CVDNVHSFTA AFLFSLETQT TIGYGYRCVT EECSVAVLTV 150
    ILQSILSCII NTFIIGAALA KMATARKRAQ TIRFSYFALI GMRDGKLCLM 200
    WRIGDFRPNH VVEGTVRAQL LRYSEDSEGR MTMAFKDLKL VNDQIILVTP 250
    VTIVHEIDHE SPLYALDRKA VAKDNFEILV TFIYTGDSTG TSHQSRSSYV 300
    PREILWGHRF HDVLEVKRKY YKVNCLQFEG SVEVYAPFCS AKQLDWKDQQ 350
    LNNLEKTSPA RGSCTSDTNT RRRSFSAVAM VSSCENPEET SLSPQDECKE 400
    VPYQKALLTL NRISMESQM 419
    Length:419
    Mass (Da):47,936
    Last modified:April 27, 2001 - v2
    Checksum:iACE54A72D511A11C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti361 – 41959RGSCT…MESQM → PRILHLGHQHQEEILQRSCH GEQL in CAA58564. (PubMed:7874445)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X83581 mRNA. Translation: CAA58564.1.
    AF249676 Genomic DNA. Translation: AAF74265.1.
    UniGeneiRn.1989.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X83581 mRNA. Translation: CAA58564.1 .
    AF249676 Genomic DNA. Translation: AAF74265.1 .
    UniGenei Rn.1989.

    3D structure databases

    ProteinModelPortali P52191.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    GuidetoPHARMACOLOGYi 440.

    PTM databases

    PhosphoSitei P52191.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    RGDi 61824. Kcnj16.

    Phylogenomic databases

    eggNOGi NOG277052.
    HOGENOMi HOG000237325.
    HOVERGENi HBG006178.
    InParanoidi P52191.
    PhylomeDBi P52191.

    Miscellaneous databases

    PROi P52191.

    Gene expression databases

    Genevestigatori P52191.

    Family and domain databases

    Gene3Di 2.60.40.1400. 1 hit.
    InterProi IPR014756. Ig_E-set.
    IPR016449. K_chnl_inward-rec_Kir.
    IPR008061. K_chnl_inward-rec_Kir5.
    IPR013518. K_chnl_inward-rec_Kir_cyto.
    [Graphical view ]
    PANTHERi PTHR11767. PTHR11767. 1 hit.
    PTHR11767:SF24. PTHR11767:SF24. 1 hit.
    Pfami PF01007. IRK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005465. GIRK_kir. 1 hit.
    PRINTSi PR01678. KIR5CHANNEL.
    PR01320. KIRCHANNEL.
    SUPFAMi SSF81296. SSF81296. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of a family of inward rectifier potassium channels."
      Bond C.T., Pessia M., Xia X.-M., Lagrutta A., Kavanaugh M.P., Adelman J.P.
      Recept. Channels 2:183-191(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Brain.
    2. "pH dependence of the inwardly rectifying potassium channel, Kir5.1, and localization in renal tubular epithelia."
      Tucker S.J., Imbrici P., Salvatore L., D'Adamo M.C., Pessia M.
      J. Biol. Chem. 275:16404-16407(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiKCJ16_RAT
    AccessioniPrimary (citable) accession number: P52191
    Secondary accession number(s): Q9JI87
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: April 27, 2001
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3