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P52183

- ANNU_SCHAM

UniProt

P52183 - ANNU_SCHAM

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Protein

Annulin

Gene
N/A
Organism
Schistocerca americana (American grasshopper)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Participates in morphogenetic activities of the cells, maybe by stabilizing the membrane or subcortical structures of cells that are under mechanical stress. Probably catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.

Catalytic activityi

Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.PROSITE-ProRule annotation

Cofactori

Ca2+By similarityNote: Binds 1 Ca(2+) ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei400 – 4001PROSITE-ProRule annotation
Active sitei427 – 4271PROSITE-ProRule annotation
Metal bindingi467 – 4671CalciumBy similarity
Metal bindingi469 – 4691CalciumBy similarity
Metal bindingi517 – 5171CalciumBy similarity
Metal bindingi522 – 5221CalciumBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein-glutamine gamma-glutamyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. peptide cross-linking Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Annulin
Alternative name(s):
Protein-glutamine gamma-glutamyltransferase (EC:2.3.2.13)
Transglutaminase
OrganismiSchistocerca americana (American grasshopper)
Taxonomic identifieri7009 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraOrthopteroideaOrthopteraCaeliferaAcridomorphaAcridoideaAcrididaeCyrtacanthacridinaeSchistocerca

Subcellular locationi

Cell membrane; Lipid-anchor; Cytoplasmic side
Note: Intracellular and peripherally associated with the inner leaflet of the cell membrane, using a fatty acid linkage.

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 772772AnnulinPRO_0000213718Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi4 – 41S-palmitoyl cysteineSequence Analysis
Lipidationi5 – 51S-palmitoyl cysteineSequence Analysis

Keywords - PTMi

Lipoprotein, Palmitate

Expressioni

Tissue specificityi

Has an annular, or ring-like expression pattern in epithelial annuli of developing limb segment boundary cells. In embryos, it is seen in gastrulating cells, in cells surrounding rapidly dividing neuroblasts, and in muscle pioneer cells invaginating to form apodemes.

Developmental stagei

Expression of this protein in embryos and limbs is associated with areas undergoing movements, morphogenetic rearrangements, or rapid cell division. Expression of annulin precedes the first morphological signs of segmentation in the developing limbs.

Structurei

3D structure databases

ProteinModelPortaliP52183.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52183-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGNCCSTFRA VFKPNEGSGG GIPLMPVRGG STRRPDSLPK PPAAVVPSPP
60 70 80 90 100
SPGDVPDAGV APEVASVKEV DVLLAENGDA HRTRHYELMD REKEPRLVVR
110 120 130 140 150
RGQPFAVSVT LSRPYNPDID AISFVFTVED AEKPSYGQGT LVAVPLLAKG
160 170 180 190 200
AESGAAWNAV LDSSADDILR IQITPAADAI VGKWKMDIDT KLKNDGAVSY
210 220 230 240 250
SYKDPFYILY NPWCRQDQVF LEGEELLQEY VLNDTGLIWR GSYNRLRPCV
260 270 280 290 300
WKYAQFEKEI LDCALYLVSK IGGVRPSECG DPVRVCRAIS AAVNSPDDNG
310 320 330 340 350
AVMGNWSNDY GGGTPPTKWI GSMKILQQFY KNKKPVKYGQ CWVFAGVLTT
360 370 380 390 400
VCRALGLPAR TVTTYSAAHD TQNSLTVDYF VDDKGEIMEE MNSDSIWNFH
410 420 430 440 450
VWTEVWMERP DLMPGDGAHY GGWQAVDSTP QELSDNMYRC GPAPVVAVKQ
460 470 480 490 500
GEVLRPYDSA YVFAEVNADK VFWRYSGPTQ PLKLIRKDML GIGQNISTKA
510 520 530 540 550
VGRFQREDIT NTYKYPEKSV EERAAMLKAL RQSESLFSRY YLNEDFNDIH
560 570 580 590 600
FNFELRDDIV IGSPFSVVVV MKNRSNQQDY TVTVLLRVDT VLYTGHVKDG
610 620 630 640 650
VKKEKVERLI KAGAVEEVRI DVSYEDYYKH LVDQCAFNIA CLATVHDTNY
660 670 680 690 700
EYFAQDDFRV RKPDIKIKLE GEPVQGQEMS AVATLKNPLP IPVKKGQFLI
710 720 730 740 750
EGPGIAKTQK IKLSQNIAPG EEASVNFKFT PKYDGRATIA AKFSSKELDD
760 770
VDGFLNFMVE PKKEVNGTGN AA
Length:772
Mass (Da):85,942
Last modified:October 1, 1996 - v1
Checksum:iFA5A3CE6A7C4E394
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M92291 mRNA. Translation: AAA29806.1.
PIRiA48822.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M92291 mRNA. Translation: AAA29806.1 .
PIRi A48822.

3D structure databases

ProteinModelPortali P52183.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProi IPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view ]
PANTHERi PTHR11590. PTHR11590. 1 hit.
Pfami PF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000459. TGM_EBP42. 1 hit.
SMARTi SM00460. TGc. 1 hit.
[Graphical view ]
SUPFAMi SSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEi PS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Annulin, a protein expressed at limb segment boundaries in the grasshopper embryo, is homologous to protein cross-linking transglutaminases."
    Singer M.A., Hortsch M., Goodman C.S., Bentley D.
    Dev. Biol. 154:143-159(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiANNU_SCHAM
AccessioniPrimary (citable) accession number: P52183
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 26, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3