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Reviewed, UniProtKB/Swiss-Prot P52181 (TGM2_PAGMA)

Last modified November 24, 2009. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Protein-glutamine gamma-glutamyltransferase 2
    EC=2.3.2.13
Alternative name(s):
    Tissue transglutaminase
    TGase C
      Short name=TGC
      Short name=TG(C)
    Transglutaminase-2
Gene names
Name: tgl2
OrganismPagrus major (Red sea bream) (Chrysophrys major)
Taxonomic identifier143350 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Acanthopterygii › Percomorpha › Perciformes › Percoidei › Sparidae › Pagrus

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Protein attributes

Sequence length695 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. May be involved in the cross-linking of myosin heavy chains in fish paste during processing.

Catalytic activity

Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.

Cofactor

Binds 1 calcium ion per subunit By similarity.

Subunit structure

Monomer By similarity.

Sequence similarities

Belongs to the transglutaminase superfamily. Transglutaminase family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 695695Protein-glutamine gamma-glutamyltransferase 2
PRO_0000213710

Sites

Active site2721 By similarity
Active site3321 By similarity
Active site3551 By similarity
Metal binding3951Calcium By similarity
Metal binding3971Calcium By similarity
Metal binding4441Calcium By similarity
Metal binding4491Calcium By similarity

Secondary structure

1 ................................................................................................................................. 695
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
P52181-1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: A9A128345D474CF8

FASTA69578,216
        10         20         30         40         50         60 
MASYKGLIVD VNGRSHENNL AHRTREIDRE RLIVRRGQPF SITLQCSDSL PPKHHLELVL 

        70         80         90        100        110        120 
HLGKRDEVVI KVQKEHGARD KWWFNQQGAQ DEILLTLHSP ANAVIGHYRL AVLVMSPDGH 

       130        140        150        160        170        180 
IVERADKISF HMLFNPWCRD DMVYLPDESK LQEYVMNEDG VIYMGTWDYI RSIPWNYGQF 

       190        200        210        220        230        240 
EDYVMDICFE VLDNSPAALK NSEMDIEHRS DPVYVGRTIT AMVNSNGDRG VLTGRWEEPY 

       250        260        270        280        290        300 
TDGVAPYRWT GSVPILQQWS KAGVRPVKYG QCWVFAAVAC TVLRCLGIPT RPITNFASAH 

       310        320        330        340        350        360 
DVDGNLSVDF LLNERLESLD SRQRSDSSWN FHCWVESWMS REDLPEGNDG WQVLDPTPQE 

       370        380        390        400        410        420 
LSDGEFCCGP CPVAAIKEGN LGVKYDAPFV FAEVNADTIY WIVQKDGQRR KITEDHASVG 

       430        440        450        460        470        480 
KNISTKSVYG NHREDVTLHY KYPEGSQKER EVYKKAGRRV TEPSNEIAEQ GRLQLSIKHA 

       490        500        510        520        530        540 
QPVFGTDFDV IVEVKNEGGR DAHAQLTMLA MAVTYNSLRR GECQRKTISV TVPAHKAHKE 

       550        560        570        580        590        600 
VMRLHYDDYV RCVSEHHLIR VKALLDAPGE NGPIMTVANI PLSTPELLVQ VPGKAVVWEP 

       610        620        630        640        650        660 
LTAYVSFTNP LPVPLKGGVF TLEGAGLLSA TQIHVNGAVA PSGKVSVKLS FSPMRTGVRK 

       670        680        690 
LLVDFDSDRL KDVKGVTTVV VHKKYRSLIT GLHTD

« Hide

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References

[1]"Tissue-type transglutaminase from red sea bream (Pagrus major). Sequence analysis of the cDNA and functional expression in Escherichia coli."
Yasueda H., Nakanishi K., Kumazawa Y., Nagase K., Motoki M., Matsui H.
Eur. J. Biochem. 232:411-419(1995) [PubMed: 7556189] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
Tissue: Liver.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		S79761 mRNA. Translation: AAB35370.1.
PIRS66662.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1G0DX-ray2.50A1-695[»]
ModBaseSearch...

Phylogenomic databases

HOVERGENP52181.

Enzyme and pathway databases

BRENDA2.3.2.13. 3296.

Family and domain databases

InterProIPR008957. Fibronectin_typ-III-like_fold.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
Gene3DG3DSA:2.60.40.30. FN_III-like. 1 hit.
G3DSA:2.60.40.10. Ig-like_fold. 1 hit.
PfamPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
SMARTSM00460. TGc. 1 hit.
[Graphical view]
PROSITEPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameTGM2_PAGMA
AccessionPrimary (citable) accession number: P52181
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 24, 2009
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

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Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents