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P52181

- TGM2_PAGMA

UniProt

P52181 - TGM2_PAGMA

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Protein

Protein-glutamine gamma-glutamyltransferase 2

Gene
tgl2
Organism
Pagrus major (Red sea bream) (Chrysophrys major)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. May be involved in the cross-linking of myosin heavy chains in fish paste during processing.

Catalytic activityi

Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.

Cofactori

Binds 1 calcium ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei272 – 2721 By similarity
Active sitei332 – 3321 By similarity
Active sitei355 – 3551 By similarity
Metal bindingi395 – 3951Calcium By similarity
Metal bindingi397 – 3971Calcium By similarity
Metal bindingi444 – 4441Calcium By similarity
Metal bindingi449 – 4491Calcium By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein-glutamine gamma-glutamyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. peptide cross-linking Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-glutamine gamma-glutamyltransferase 2 (EC:2.3.2.13)
Alternative name(s):
Tissue transglutaminase
Transglutaminase C
Short name:
TG(C)
Short name:
TGC
Short name:
TGase C
Transglutaminase-2
Short name:
TGase-2
Gene namesi
Name:tgl2
OrganismiPagrus major (Red sea bream) (Chrysophrys major)
Taxonomic identifieri143350 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPercomorphariaSpariformesSparidaePagrus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 695695Protein-glutamine gamma-glutamyltransferase 2PRO_0000213710Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.

Structurei

Secondary structure

1
695
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi8 – 125
Helixi15 – 217
Turni25 – 273
Beta strandi29 – 313
Beta strandi33 – 353
Beta strandi40 – 489
Beta strandi55 – 639
Beta strandi67 – 7610
Beta strandi79 – 813
Beta strandi83 – 886
Beta strandi90 – 989
Beta strandi106 – 11510
Beta strandi121 – 1244
Beta strandi128 – 1336
Helixi148 – 1547
Beta strandi159 – 1668
Beta strandi169 – 1768
Helixi184 – 19310
Helixi196 – 2005
Helixi202 – 2087
Helixi212 – 22312
Turni227 – 2293
Beta strandi231 – 2344
Helixi246 – 2483
Beta strandi250 – 2523
Helixi253 – 2619
Beta strandi267 – 2704
Helixi272 – 28615
Beta strandi290 – 2989
Turni301 – 3044
Beta strandi306 – 3127
Beta strandi327 – 33913
Beta strandi350 – 3556
Turni363 – 3653
Beta strandi368 – 3725
Helixi373 – 3786
Turni384 – 3863
Helixi387 – 3959
Beta strandi397 – 4037
Beta strandi409 – 4113
Beta strandi413 – 4164
Beta strandi424 – 4263
Beta strandi428 – 4314
Beta strandi433 – 4353
Helixi437 – 4404
Helixi447 – 45610
Beta strandi473 – 4786
Beta strandi488 – 4969
Beta strandi498 – 5003
Beta strandi502 – 51312
Beta strandi525 – 5328
Beta strandi536 – 5449
Helixi546 – 5494
Turni550 – 5523
Beta strandi558 – 5669
Beta strandi573 – 5819
Beta strandi588 – 5903
Beta strandi601 – 6088
Beta strandi611 – 6133
Beta strandi615 – 6173
Beta strandi619 – 6246
Turni625 – 6273
Beta strandi628 – 6347
Beta strandi636 – 6394
Beta strandi644 – 6518
Beta strandi657 – 66610
Beta strandi673 – 68210

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1G0DX-ray2.50A1-695[»]
ProteinModelPortaliP52181.
SMRiP52181. Positions 6-684.

Miscellaneous databases

EvolutionaryTraceiP52181.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG004342.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52181-1 [UniParc]FASTAAdd to Basket

« Hide

MASYKGLIVD VNGRSHENNL AHRTREIDRE RLIVRRGQPF SITLQCSDSL    50
PPKHHLELVL HLGKRDEVVI KVQKEHGARD KWWFNQQGAQ DEILLTLHSP 100
ANAVIGHYRL AVLVMSPDGH IVERADKISF HMLFNPWCRD DMVYLPDESK 150
LQEYVMNEDG VIYMGTWDYI RSIPWNYGQF EDYVMDICFE VLDNSPAALK 200
NSEMDIEHRS DPVYVGRTIT AMVNSNGDRG VLTGRWEEPY TDGVAPYRWT 250
GSVPILQQWS KAGVRPVKYG QCWVFAAVAC TVLRCLGIPT RPITNFASAH 300
DVDGNLSVDF LLNERLESLD SRQRSDSSWN FHCWVESWMS REDLPEGNDG 350
WQVLDPTPQE LSDGEFCCGP CPVAAIKEGN LGVKYDAPFV FAEVNADTIY 400
WIVQKDGQRR KITEDHASVG KNISTKSVYG NHREDVTLHY KYPEGSQKER 450
EVYKKAGRRV TEPSNEIAEQ GRLQLSIKHA QPVFGTDFDV IVEVKNEGGR 500
DAHAQLTMLA MAVTYNSLRR GECQRKTISV TVPAHKAHKE VMRLHYDDYV 550
RCVSEHHLIR VKALLDAPGE NGPIMTVANI PLSTPELLVQ VPGKAVVWEP 600
LTAYVSFTNP LPVPLKGGVF TLEGAGLLSA TQIHVNGAVA PSGKVSVKLS 650
FSPMRTGVRK LLVDFDSDRL KDVKGVTTVV VHKKYRSLIT GLHTD 695
Length:695
Mass (Da):78,216
Last modified:October 1, 1996 - v1
Checksum:iA9A128345D474CF8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S79761 mRNA. Translation: AAB35370.1.
PIRiS66662.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S79761 mRNA. Translation: AAB35370.1 .
PIRi S66662.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1G0D X-ray 2.50 A 1-695 [» ]
ProteinModelPortali P52181.
SMRi P52181. Positions 6-684.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG004342.

Miscellaneous databases

EvolutionaryTracei P52181.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProi IPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view ]
PANTHERi PTHR11590. PTHR11590. 1 hit.
Pfami PF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000459. TGM_EBP42. 1 hit.
SMARTi SM00460. TGc. 1 hit.
[Graphical view ]
SUPFAMi SSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEi PS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Tissue-type transglutaminase from red sea bream (Pagrus major). Sequence analysis of the cDNA and functional expression in Escherichia coli."
    Yasueda H., Nakanishi K., Kumazawa Y., Nagase K., Motoki M., Matsui H.
    Eur. J. Biochem. 232:411-419(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Tissue: Liver.

Entry informationi

Entry nameiTGM2_PAGMA
AccessioniPrimary (citable) accession number: P52181
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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