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Protein

Protein-glutamine gamma-glutamyltransferase 2

Gene

tgl2

Organism
Pagrus major (Red sea bream) (Chrysophrys major)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. May be involved in the cross-linking of myosin heavy chains in fish paste during processing.

Catalytic activityi

Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.PROSITE-ProRule annotation

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei272PROSITE-ProRule annotation1
Active sitei332PROSITE-ProRule annotation1
Active sitei355PROSITE-ProRule annotation1
Metal bindingi395CalciumBy similarity1
Metal bindingi397CalciumBy similarity1
Metal bindingi444CalciumBy similarity1
Metal bindingi449CalciumBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-glutamine gamma-glutamyltransferase 2 (EC:2.3.2.13)
Alternative name(s):
Tissue transglutaminase
Transglutaminase C
Short name:
TG(C)
Short name:
TGC
Short name:
TGase C
Transglutaminase-2
Short name:
TGase-2
Gene namesi
Name:tgl2
OrganismiPagrus major (Red sea bream) (Chrysophrys major)
Taxonomic identifieri143350 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaSpariformesSparidaePagrus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002137101 – 695Protein-glutamine gamma-glutamyltransferase 2Add BLAST695

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

Secondary structure

1695
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 12Combined sources5
Helixi15 – 21Combined sources7
Turni25 – 27Combined sources3
Beta strandi29 – 31Combined sources3
Beta strandi33 – 35Combined sources3
Beta strandi40 – 48Combined sources9
Beta strandi55 – 63Combined sources9
Beta strandi67 – 76Combined sources10
Beta strandi79 – 81Combined sources3
Beta strandi83 – 88Combined sources6
Beta strandi90 – 98Combined sources9
Beta strandi106 – 115Combined sources10
Beta strandi121 – 124Combined sources4
Beta strandi128 – 133Combined sources6
Helixi148 – 154Combined sources7
Beta strandi159 – 166Combined sources8
Beta strandi169 – 176Combined sources8
Helixi184 – 193Combined sources10
Helixi196 – 200Combined sources5
Helixi202 – 208Combined sources7
Helixi212 – 223Combined sources12
Turni227 – 229Combined sources3
Beta strandi231 – 234Combined sources4
Helixi246 – 248Combined sources3
Beta strandi250 – 252Combined sources3
Helixi253 – 261Combined sources9
Beta strandi267 – 270Combined sources4
Helixi272 – 286Combined sources15
Beta strandi290 – 298Combined sources9
Turni301 – 304Combined sources4
Beta strandi306 – 312Combined sources7
Beta strandi327 – 339Combined sources13
Beta strandi350 – 355Combined sources6
Turni363 – 365Combined sources3
Beta strandi368 – 372Combined sources5
Helixi373 – 378Combined sources6
Turni384 – 386Combined sources3
Helixi387 – 395Combined sources9
Beta strandi397 – 403Combined sources7
Beta strandi409 – 411Combined sources3
Beta strandi413 – 416Combined sources4
Beta strandi424 – 426Combined sources3
Beta strandi428 – 431Combined sources4
Beta strandi433 – 435Combined sources3
Helixi437 – 440Combined sources4
Helixi447 – 456Combined sources10
Beta strandi473 – 478Combined sources6
Beta strandi488 – 496Combined sources9
Beta strandi498 – 500Combined sources3
Beta strandi502 – 513Combined sources12
Beta strandi525 – 532Combined sources8
Beta strandi536 – 544Combined sources9
Helixi546 – 549Combined sources4
Turni550 – 552Combined sources3
Beta strandi558 – 566Combined sources9
Beta strandi573 – 581Combined sources9
Beta strandi588 – 590Combined sources3
Beta strandi601 – 608Combined sources8
Beta strandi611 – 613Combined sources3
Beta strandi615 – 617Combined sources3
Beta strandi619 – 624Combined sources6
Turni625 – 627Combined sources3
Beta strandi628 – 634Combined sources7
Beta strandi636 – 639Combined sources4
Beta strandi644 – 651Combined sources8
Beta strandi657 – 666Combined sources10
Beta strandi673 – 682Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G0DX-ray2.50A1-695[»]
ProteinModelPortaliP52181.
SMRiP52181.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP52181.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG004342.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR013808. Transglutaminase_AS.
IPR008958. Transglutaminase_C.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 1 hit.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52181-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASYKGLIVD VNGRSHENNL AHRTREIDRE RLIVRRGQPF SITLQCSDSL
60 70 80 90 100
PPKHHLELVL HLGKRDEVVI KVQKEHGARD KWWFNQQGAQ DEILLTLHSP
110 120 130 140 150
ANAVIGHYRL AVLVMSPDGH IVERADKISF HMLFNPWCRD DMVYLPDESK
160 170 180 190 200
LQEYVMNEDG VIYMGTWDYI RSIPWNYGQF EDYVMDICFE VLDNSPAALK
210 220 230 240 250
NSEMDIEHRS DPVYVGRTIT AMVNSNGDRG VLTGRWEEPY TDGVAPYRWT
260 270 280 290 300
GSVPILQQWS KAGVRPVKYG QCWVFAAVAC TVLRCLGIPT RPITNFASAH
310 320 330 340 350
DVDGNLSVDF LLNERLESLD SRQRSDSSWN FHCWVESWMS REDLPEGNDG
360 370 380 390 400
WQVLDPTPQE LSDGEFCCGP CPVAAIKEGN LGVKYDAPFV FAEVNADTIY
410 420 430 440 450
WIVQKDGQRR KITEDHASVG KNISTKSVYG NHREDVTLHY KYPEGSQKER
460 470 480 490 500
EVYKKAGRRV TEPSNEIAEQ GRLQLSIKHA QPVFGTDFDV IVEVKNEGGR
510 520 530 540 550
DAHAQLTMLA MAVTYNSLRR GECQRKTISV TVPAHKAHKE VMRLHYDDYV
560 570 580 590 600
RCVSEHHLIR VKALLDAPGE NGPIMTVANI PLSTPELLVQ VPGKAVVWEP
610 620 630 640 650
LTAYVSFTNP LPVPLKGGVF TLEGAGLLSA TQIHVNGAVA PSGKVSVKLS
660 670 680 690
FSPMRTGVRK LLVDFDSDRL KDVKGVTTVV VHKKYRSLIT GLHTD
Length:695
Mass (Da):78,216
Last modified:October 1, 1996 - v1
Checksum:iA9A128345D474CF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S79761 mRNA. Translation: AAB35370.1.
PIRiS66662.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S79761 mRNA. Translation: AAB35370.1.
PIRiS66662.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G0DX-ray2.50A1-695[»]
ProteinModelPortaliP52181.
SMRiP52181.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG004342.

Miscellaneous databases

EvolutionaryTraceiP52181.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR013808. Transglutaminase_AS.
IPR008958. Transglutaminase_C.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 1 hit.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTGM2_PAGMA
AccessioniPrimary (citable) accession number: P52181
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.