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P52181

- TGM2_PAGMA

UniProt

P52181 - TGM2_PAGMA

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Protein

Protein-glutamine gamma-glutamyltransferase 2

Gene

tgl2

Organism
Pagrus major (Red sea bream) (Chrysophrys major)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. May be involved in the cross-linking of myosin heavy chains in fish paste during processing.

Catalytic activityi

Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.PROSITE-ProRule annotation

Cofactori

Binds 1 calcium ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei272 – 2721PROSITE-ProRule annotation
Active sitei332 – 3321PROSITE-ProRule annotation
Active sitei355 – 3551PROSITE-ProRule annotation
Metal bindingi395 – 3951CalciumBy similarity
Metal bindingi397 – 3971CalciumBy similarity
Metal bindingi444 – 4441CalciumBy similarity
Metal bindingi449 – 4491CalciumBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein-glutamine gamma-glutamyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. peptide cross-linking Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-glutamine gamma-glutamyltransferase 2 (EC:2.3.2.13)
Alternative name(s):
Tissue transglutaminase
Transglutaminase C
Short name:
TG(C)
Short name:
TGC
Short name:
TGase C
Transglutaminase-2
Short name:
TGase-2
Gene namesi
Name:tgl2
OrganismiPagrus major (Red sea bream) (Chrysophrys major)
Taxonomic identifieri143350 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaSpariformesSparidaePagrus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 695695Protein-glutamine gamma-glutamyltransferase 2PRO_0000213710Add
BLAST

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

Secondary structure

1
695
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi8 – 125Combined sources
Helixi15 – 217Combined sources
Turni25 – 273Combined sources
Beta strandi29 – 313Combined sources
Beta strandi33 – 353Combined sources
Beta strandi40 – 489Combined sources
Beta strandi55 – 639Combined sources
Beta strandi67 – 7610Combined sources
Beta strandi79 – 813Combined sources
Beta strandi83 – 886Combined sources
Beta strandi90 – 989Combined sources
Beta strandi106 – 11510Combined sources
Beta strandi121 – 1244Combined sources
Beta strandi128 – 1336Combined sources
Helixi148 – 1547Combined sources
Beta strandi159 – 1668Combined sources
Beta strandi169 – 1768Combined sources
Helixi184 – 19310Combined sources
Helixi196 – 2005Combined sources
Helixi202 – 2087Combined sources
Helixi212 – 22312Combined sources
Turni227 – 2293Combined sources
Beta strandi231 – 2344Combined sources
Helixi246 – 2483Combined sources
Beta strandi250 – 2523Combined sources
Helixi253 – 2619Combined sources
Beta strandi267 – 2704Combined sources
Helixi272 – 28615Combined sources
Beta strandi290 – 2989Combined sources
Turni301 – 3044Combined sources
Beta strandi306 – 3127Combined sources
Beta strandi327 – 33913Combined sources
Beta strandi350 – 3556Combined sources
Turni363 – 3653Combined sources
Beta strandi368 – 3725Combined sources
Helixi373 – 3786Combined sources
Turni384 – 3863Combined sources
Helixi387 – 3959Combined sources
Beta strandi397 – 4037Combined sources
Beta strandi409 – 4113Combined sources
Beta strandi413 – 4164Combined sources
Beta strandi424 – 4263Combined sources
Beta strandi428 – 4314Combined sources
Beta strandi433 – 4353Combined sources
Helixi437 – 4404Combined sources
Helixi447 – 45610Combined sources
Beta strandi473 – 4786Combined sources
Beta strandi488 – 4969Combined sources
Beta strandi498 – 5003Combined sources
Beta strandi502 – 51312Combined sources
Beta strandi525 – 5328Combined sources
Beta strandi536 – 5449Combined sources
Helixi546 – 5494Combined sources
Turni550 – 5523Combined sources
Beta strandi558 – 5669Combined sources
Beta strandi573 – 5819Combined sources
Beta strandi588 – 5903Combined sources
Beta strandi601 – 6088Combined sources
Beta strandi611 – 6133Combined sources
Beta strandi615 – 6173Combined sources
Beta strandi619 – 6246Combined sources
Turni625 – 6273Combined sources
Beta strandi628 – 6347Combined sources
Beta strandi636 – 6394Combined sources
Beta strandi644 – 6518Combined sources
Beta strandi657 – 66610Combined sources
Beta strandi673 – 68210Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1G0DX-ray2.50A1-695[»]
ProteinModelPortaliP52181.
SMRiP52181. Positions 6-684.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP52181.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG004342.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52181 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASYKGLIVD VNGRSHENNL AHRTREIDRE RLIVRRGQPF SITLQCSDSL
60 70 80 90 100
PPKHHLELVL HLGKRDEVVI KVQKEHGARD KWWFNQQGAQ DEILLTLHSP
110 120 130 140 150
ANAVIGHYRL AVLVMSPDGH IVERADKISF HMLFNPWCRD DMVYLPDESK
160 170 180 190 200
LQEYVMNEDG VIYMGTWDYI RSIPWNYGQF EDYVMDICFE VLDNSPAALK
210 220 230 240 250
NSEMDIEHRS DPVYVGRTIT AMVNSNGDRG VLTGRWEEPY TDGVAPYRWT
260 270 280 290 300
GSVPILQQWS KAGVRPVKYG QCWVFAAVAC TVLRCLGIPT RPITNFASAH
310 320 330 340 350
DVDGNLSVDF LLNERLESLD SRQRSDSSWN FHCWVESWMS REDLPEGNDG
360 370 380 390 400
WQVLDPTPQE LSDGEFCCGP CPVAAIKEGN LGVKYDAPFV FAEVNADTIY
410 420 430 440 450
WIVQKDGQRR KITEDHASVG KNISTKSVYG NHREDVTLHY KYPEGSQKER
460 470 480 490 500
EVYKKAGRRV TEPSNEIAEQ GRLQLSIKHA QPVFGTDFDV IVEVKNEGGR
510 520 530 540 550
DAHAQLTMLA MAVTYNSLRR GECQRKTISV TVPAHKAHKE VMRLHYDDYV
560 570 580 590 600
RCVSEHHLIR VKALLDAPGE NGPIMTVANI PLSTPELLVQ VPGKAVVWEP
610 620 630 640 650
LTAYVSFTNP LPVPLKGGVF TLEGAGLLSA TQIHVNGAVA PSGKVSVKLS
660 670 680 690
FSPMRTGVRK LLVDFDSDRL KDVKGVTTVV VHKKYRSLIT GLHTD
Length:695
Mass (Da):78,216
Last modified:October 1, 1996 - v1
Checksum:iA9A128345D474CF8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S79761 mRNA. Translation: AAB35370.1.
PIRiS66662.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S79761 mRNA. Translation: AAB35370.1 .
PIRi S66662.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1G0D X-ray 2.50 A 1-695 [» ]
ProteinModelPortali P52181.
SMRi P52181. Positions 6-684.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG004342.

Miscellaneous databases

EvolutionaryTracei P52181.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProi IPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view ]
PANTHERi PTHR11590. PTHR11590. 1 hit.
Pfami PF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000459. TGM_EBP42. 1 hit.
SMARTi SM00460. TGc. 1 hit.
[Graphical view ]
SUPFAMi SSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEi PS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Tissue-type transglutaminase from red sea bream (Pagrus major). Sequence analysis of the cDNA and functional expression in Escherichia coli."
    Yasueda H., Nakanishi K., Kumazawa Y., Nagase K., Motoki M., Matsui H.
    Eur. J. Biochem. 232:411-419(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Tissue: Liver.

Entry informationi

Entry nameiTGM2_PAGMA
AccessioniPrimary (citable) accession number: P52181
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3