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P52181

- TGM2_PAGMA

UniProt

P52181 - TGM2_PAGMA

Protein

Protein-glutamine gamma-glutamyltransferase 2

Gene

tgl2

Organism
Pagrus major (Red sea bream) (Chrysophrys major)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. May be involved in the cross-linking of myosin heavy chains in fish paste during processing.

    Catalytic activityi

    Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.PROSITE-ProRule annotation

    Cofactori

    Binds 1 calcium ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei272 – 2721PROSITE-ProRule annotation
    Active sitei332 – 3321PROSITE-ProRule annotation
    Active sitei355 – 3551PROSITE-ProRule annotation
    Metal bindingi395 – 3951CalciumBy similarity
    Metal bindingi397 – 3971CalciumBy similarity
    Metal bindingi444 – 4441CalciumBy similarity
    Metal bindingi449 – 4491CalciumBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein-glutamine gamma-glutamyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. peptide cross-linking Source: InterPro

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein-glutamine gamma-glutamyltransferase 2 (EC:2.3.2.13)
    Alternative name(s):
    Tissue transglutaminase
    Transglutaminase C
    Short name:
    TG(C)
    Short name:
    TGC
    Short name:
    TGase C
    Transglutaminase-2
    Short name:
    TGase-2
    Gene namesi
    Name:tgl2
    OrganismiPagrus major (Red sea bream) (Chrysophrys major)
    Taxonomic identifieri143350 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPercomorphariaSpariformesSparidaePagrus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 695695Protein-glutamine gamma-glutamyltransferase 2PRO_0000213710Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Structurei

    Secondary structure

    1
    695
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi8 – 125
    Helixi15 – 217
    Turni25 – 273
    Beta strandi29 – 313
    Beta strandi33 – 353
    Beta strandi40 – 489
    Beta strandi55 – 639
    Beta strandi67 – 7610
    Beta strandi79 – 813
    Beta strandi83 – 886
    Beta strandi90 – 989
    Beta strandi106 – 11510
    Beta strandi121 – 1244
    Beta strandi128 – 1336
    Helixi148 – 1547
    Beta strandi159 – 1668
    Beta strandi169 – 1768
    Helixi184 – 19310
    Helixi196 – 2005
    Helixi202 – 2087
    Helixi212 – 22312
    Turni227 – 2293
    Beta strandi231 – 2344
    Helixi246 – 2483
    Beta strandi250 – 2523
    Helixi253 – 2619
    Beta strandi267 – 2704
    Helixi272 – 28615
    Beta strandi290 – 2989
    Turni301 – 3044
    Beta strandi306 – 3127
    Beta strandi327 – 33913
    Beta strandi350 – 3556
    Turni363 – 3653
    Beta strandi368 – 3725
    Helixi373 – 3786
    Turni384 – 3863
    Helixi387 – 3959
    Beta strandi397 – 4037
    Beta strandi409 – 4113
    Beta strandi413 – 4164
    Beta strandi424 – 4263
    Beta strandi428 – 4314
    Beta strandi433 – 4353
    Helixi437 – 4404
    Helixi447 – 45610
    Beta strandi473 – 4786
    Beta strandi488 – 4969
    Beta strandi498 – 5003
    Beta strandi502 – 51312
    Beta strandi525 – 5328
    Beta strandi536 – 5449
    Helixi546 – 5494
    Turni550 – 5523
    Beta strandi558 – 5669
    Beta strandi573 – 5819
    Beta strandi588 – 5903
    Beta strandi601 – 6088
    Beta strandi611 – 6133
    Beta strandi615 – 6173
    Beta strandi619 – 6246
    Turni625 – 6273
    Beta strandi628 – 6347
    Beta strandi636 – 6394
    Beta strandi644 – 6518
    Beta strandi657 – 66610
    Beta strandi673 – 68210

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1G0DX-ray2.50A1-695[»]
    ProteinModelPortaliP52181.
    SMRiP52181. Positions 6-684.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP52181.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    HOVERGENiHBG004342.

    Family and domain databases

    Gene3Di2.60.40.10. 3 hits.
    3.90.260.10. 1 hit.
    InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002931. Transglutaminase-like.
    IPR008958. Transglutaminase_C.
    IPR013808. Transglutaminase_CS.
    IPR001102. Transglutaminase_N.
    [Graphical view]
    PANTHERiPTHR11590. PTHR11590. 1 hit.
    PfamiPF00927. Transglut_C. 2 hits.
    PF01841. Transglut_core. 1 hit.
    PF00868. Transglut_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
    SMARTiSM00460. TGc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49309. SSF49309. 2 hits.
    SSF81296. SSF81296. 1 hit.
    PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P52181-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASYKGLIVD VNGRSHENNL AHRTREIDRE RLIVRRGQPF SITLQCSDSL    50
    PPKHHLELVL HLGKRDEVVI KVQKEHGARD KWWFNQQGAQ DEILLTLHSP 100
    ANAVIGHYRL AVLVMSPDGH IVERADKISF HMLFNPWCRD DMVYLPDESK 150
    LQEYVMNEDG VIYMGTWDYI RSIPWNYGQF EDYVMDICFE VLDNSPAALK 200
    NSEMDIEHRS DPVYVGRTIT AMVNSNGDRG VLTGRWEEPY TDGVAPYRWT 250
    GSVPILQQWS KAGVRPVKYG QCWVFAAVAC TVLRCLGIPT RPITNFASAH 300
    DVDGNLSVDF LLNERLESLD SRQRSDSSWN FHCWVESWMS REDLPEGNDG 350
    WQVLDPTPQE LSDGEFCCGP CPVAAIKEGN LGVKYDAPFV FAEVNADTIY 400
    WIVQKDGQRR KITEDHASVG KNISTKSVYG NHREDVTLHY KYPEGSQKER 450
    EVYKKAGRRV TEPSNEIAEQ GRLQLSIKHA QPVFGTDFDV IVEVKNEGGR 500
    DAHAQLTMLA MAVTYNSLRR GECQRKTISV TVPAHKAHKE VMRLHYDDYV 550
    RCVSEHHLIR VKALLDAPGE NGPIMTVANI PLSTPELLVQ VPGKAVVWEP 600
    LTAYVSFTNP LPVPLKGGVF TLEGAGLLSA TQIHVNGAVA PSGKVSVKLS 650
    FSPMRTGVRK LLVDFDSDRL KDVKGVTTVV VHKKYRSLIT GLHTD 695
    Length:695
    Mass (Da):78,216
    Last modified:October 1, 1996 - v1
    Checksum:iA9A128345D474CF8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S79761 mRNA. Translation: AAB35370.1.
    PIRiS66662.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S79761 mRNA. Translation: AAB35370.1 .
    PIRi S66662.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1G0D X-ray 2.50 A 1-695 [» ]
    ProteinModelPortali P52181.
    SMRi P52181. Positions 6-684.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG004342.

    Miscellaneous databases

    EvolutionaryTracei P52181.

    Family and domain databases

    Gene3Di 2.60.40.10. 3 hits.
    3.90.260.10. 1 hit.
    InterProi IPR023608. Gln_gamma-glutamylTfrase_euk.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002931. Transglutaminase-like.
    IPR008958. Transglutaminase_C.
    IPR013808. Transglutaminase_CS.
    IPR001102. Transglutaminase_N.
    [Graphical view ]
    PANTHERi PTHR11590. PTHR11590. 1 hit.
    Pfami PF00927. Transglut_C. 2 hits.
    PF01841. Transglut_core. 1 hit.
    PF00868. Transglut_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000459. TGM_EBP42. 1 hit.
    SMARTi SM00460. TGc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49309. SSF49309. 2 hits.
    SSF81296. SSF81296. 1 hit.
    PROSITEi PS00547. TRANSGLUTAMINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Tissue-type transglutaminase from red sea bream (Pagrus major). Sequence analysis of the cDNA and functional expression in Escherichia coli."
      Yasueda H., Nakanishi K., Kumazawa Y., Nagase K., Motoki M., Matsui H.
      Eur. J. Biochem. 232:411-419(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
      Tissue: Liver.

    Entry informationi

    Entry nameiTGM2_PAGMA
    AccessioniPrimary (citable) accession number: P52181
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3