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P52179

- MYOM1_HUMAN

UniProt

P52179 - MYOM1_HUMAN

Protein

Myomesin-1

Gene

MYOM1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 2 (04 Nov 2008)
      Previous versions | rss
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    Functioni

    Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.

    GO - Molecular functioni

    1. identical protein binding Source: IntAct
    2. protein binding Source: IntAct
    3. protein homodimerization activity Source: UniProtKB
    4. structural constituent of muscle Source: ProtInc

    GO - Biological processi

    1. muscle contraction Source: Ensembl

    Keywords - Molecular functioni

    Muscle protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myomesin-1
    Alternative name(s):
    190 kDa connectin-associated protein
    190 kDa titin-associated protein
    Myomesin family member 1
    Gene namesi
    Name:MYOM1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:7613. MYOM1.

    Subcellular locationi

    CytoplasmmyofibrilsarcomereM line By similarity

    GO - Cellular componenti

    1. M band Source: UniProtKB
    2. striated muscle myosin thick filament Source: ProtInc

    Keywords - Cellular componenti

    Cytoplasm, Thick filament

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31418.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 16851685Myomesin-1PRO_0000072684Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi1160 ↔ 1210PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP52179.
    PRIDEiP52179.

    PTM databases

    PhosphoSiteiP52179.

    Expressioni

    Gene expression databases

    ArrayExpressiP52179.
    BgeeiP52179.
    CleanExiHS_MYOM1.
    GenevestigatoriP52179.

    Organism-specific databases

    HPAiHPA014305.

    Interactioni

    Subunit structurei

    Homodimer By similarity. Interacts with TTN/titin By similarity. Interacts with PNKD.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself4EBI-5353249,EBI-5353249
    DYSFO759233EBI-5353249,EBI-2799016

    Protein-protein interaction databases

    DIPiDIP-59649N.
    IntActiP52179. 6 interactions.
    STRINGi9606.ENSP00000348821.

    Structurei

    Secondary structure

    1
    1685
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi1145 – 11484
    Beta strandi1154 – 11596
    Beta strandi1169 – 11735
    Beta strandi1184 – 11896
    Beta strandi1192 – 11998
    Helixi1202 – 12043
    Beta strandi1206 – 121510
    Beta strandi1220 – 12245
    Helixi1226 – 124015
    Beta strandi1248 – 12547
    Helixi1256 – 12583
    Beta strandi1260 – 12656
    Beta strandi1274 – 12796
    Beta strandi1282 – 12843
    Beta strandi1286 – 12894
    Beta strandi1291 – 12944
    Turni1296 – 12983
    Beta strandi1300 – 13067
    Helixi1310 – 13123
    Beta strandi1314 – 13229
    Beta strandi1325 – 13339
    Helixi1336 – 135520
    Beta strandi1357 – 136913
    Turni1370 – 13723
    Beta strandi1373 – 138210
    Beta strandi1388 – 13936
    Beta strandi1396 – 13983
    Beta strandi1407 – 14159
    Helixi1420 – 14223
    Beta strandi1424 – 14329
    Beta strandi1435 – 14439
    Helixi1446 – 146015
    Beta strandi1467 – 14704
    Beta strandi1472 – 148312
    Beta strandi1489 – 14946
    Beta strandi1503 – 15108
    Beta strandi1513 – 15208
    Helixi1523 – 15253
    Beta strandi1527 – 15348
    Beta strandi1539 – 15468
    Helixi1548 – 157023
    Beta strandi1573 – 15775
    Beta strandi1580 – 15856
    Beta strandi1590 – 15978
    Beta strandi1603 – 16086
    Beta strandi1611 – 16133
    Beta strandi1617 – 16248
    Turni1625 – 16273
    Beta strandi1628 – 16358
    Helixi1638 – 16403
    Beta strandi1642 – 16509
    Beta strandi1653 – 166412

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2R15X-ray2.24A/B1459-1667[»]
    2Y23X-ray2.50A1141-1447[»]
    2Y25X-ray3.50A/B/C/D1357-1667[»]
    3RBSX-ray1.85A1247-1447[»]
    DisProtiDP00517.
    ProteinModelPortaliP52179.
    SMRiP52179. Positions 273-734, 751-834, 930-1024, 1039-1139, 1141-1666.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP52179.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati182 – 18761
    Repeati188 – 19362
    Repeati194 – 19963
    Repeati200 – 20564
    Repeati206 – 21165
    Repeati212 – 21766
    Domaini277 – 36892Ig-like C2-type 1Add
    BLAST
    Domaini396 – 498103Ig-like C2-type 2Add
    BLAST
    Domaini512 – 60796Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini640 – 73495Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini741 – 83494Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini933 – 1034102Fibronectin type-III 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini1041 – 1140100Fibronectin type-III 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini1132 – 123099Ig-like C2-type 3Add
    BLAST
    Domaini1358 – 144487Ig-like C2-type 4Add
    BLAST
    Domaini1573 – 166290Ig-like C2-type 5Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni182 – 217366 X 6 AA tandem repeatsAdd
    BLAST

    Sequence similaritiesi

    Contains 5 fibronectin type-III domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat

    Phylogenomic databases

    eggNOGiNOG281933.
    HOGENOMiHOG000293283.
    HOVERGENiHBG004977.
    InParanoidiP52179.
    OMAiYIIESRY.
    OrthoDBiEOG7MSMN2.
    PhylomeDBiP52179.
    TreeFamiTF331825.

    Family and domain databases

    Gene3Di2.60.40.10. 12 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    [Graphical view]
    PfamiPF00041. fn3. 5 hits.
    PF07679. I-set. 5 hits.
    [Graphical view]
    SMARTiSM00060. FN3. 5 hits.
    SM00409. IG. 3 hits.
    SM00408. IGc2. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 3 hits.
    PROSITEiPS50853. FN3. 5 hits.
    PS50835. IG_LIKE. 4 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P52179-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSLPFYQRCH QHYDLSYRNK DVRSTVSHYQ REKKRSAVYT QGSTAYSSRS     50
    SAAHRRESEA FRRASASSSQ QQASQHALSS EVSRKAASAY DYGSSHGLTD 100
    SSLLLDDYSS KLSPKPKRAK HSLLSGEEKE NLPSDYMVPI FSGRQKHVSG 150
    ITDTEEERIK EAAAYIAQRN LLASEEGITT SKQSTASKQT TASKQSTASK 200
    QSTASKQSTA SRQSTASRQS VVSKQATSAL QQEETSEKKS RKVVIREKAE 250
    RLSLRKTLEE TETYHAKLNE DHLLHAPEFI IKPRSHTVWE KENVKLHCSI 300
    AGWPEPRVTW YKNQVPINVH ANPGKYIIES RYGMHTLEIN GCDFEDTAQY 350
    RASAMNVKGE LSAYASVVVK RYKGEFDETR FHAGASTMPL SFGVTPYGYA 400
    SRFEIHFDDK FDVSFGREGE TMSLGCRVVI TPEIKHFQPE IQWYRNGVPL 450
    SPSKWVQTLW SGERATLTFS HLNKEDEGLY TIRVRMGEYY EQYSAYVFVR 500
    DADAEIEGAP AAPLDVKCLE ANKDYIIISW KQPAVDGGSP ILGYFIDKCE 550
    VGTDSWSQCN DTPVKFARFP VTGLIEGRSY IFRVRAVNKM GIGFPSRVSE 600
    PVAALDPAEK ARLKSRPSAP WTGQIIVTEE EPSEGIVPGP PTDLSVTEAT 650
    RSYVVLSWKP PGQRGHEGIM YFVEKCEAGT ENWQRVNTEL PVKSPRFALF 700
    DLAEGKSYCF RVRCSNSAGV GEPSEATEVT VVGDKLDIPK APGKIIPSRN 750
    TDTSVVVSWE ESKDAKELVG YYIEASVAGS GKWEPCNNNP VKGSRFTCHG 800
    LVTGQSYIFR VRAVNAAGLS EYSQDSEAIE VKAAIGGGVS PDVCPALSDE 850
    PGGLTASRGR VHEASPPTFQ KDALLGSKPN KPSLPSSSQN LGQTEVSKVS 900
    ETVQEELTPP PQKAAPQGKS KSDPLKKKTD RAPPSPPCDI TCLESFRDSM 950
    VLGWKQPDKI GGAEITGYYV NYREVIDGVP GKWREANVKA VSEEAYKISN 1000
    LKENMVYQFQ VAAMNMAGLG APSAVSECFK CEEWTIAVPG PPHSLKCSEV 1050
    RKDSLVLQWK PPVHSGRTPV TGYFVDLKEA KAKEDQWRGL NEAAIKNVYL 1100
    KVRGLKEGVS YVFRVRAINQ AGVGKPSDLA GPVVAETRPG TKEVVVNVDD 1150
    DGVISLNFEC DKMTPKSEFS WSKDYVSTED SPRLEVESKG NKTKMTFKDL 1200
    GMDDLGIYSC DVTDTDGIAS SYLIDEEELK RLLALSHEHK FPTVPVKSEL 1250
    AVEILEKGQV RFWMQAEKLS GNAKVNYIFN EKEIFEGPKY KMHIDRNTGI 1300
    IEMFMEKLQD EDEGTYTFQL QDGKATNHST VVLVGDVFKK LQKEAEFQRQ 1350
    EWIRKQGPHF VEYLSWEVTG ECNVLLKCKV ANIKKETHIV WYKDEREISV 1400
    DEKHDFKDGI CTLLITEFSK KDAGIYEVIL KDDRGKDKSR LKLVDEAFKE 1450
    LMMEVCKKIA LSATDLKIQS TAEGIQLYSF VTYYVEDLKV NWSHNGSAIR 1500
    YSDRVKTGVT GEQIWLQINE PTPNDKGKYV MELFDGKTGH QKTVDLSGQA 1550
    YDEAYAEFQR LKQAAIAEKN RARVLGGLPD VVTIQEGKAL NLTCNVWGDP 1600
    PPEVSWLKNE KALASDDHCN LKFEAGRTAY FTINGVSTAD SGKYGLVVKN 1650
    KYGSETSDFT VSVFIPEEEA RMAALESLKG GKKAK 1685
    Length:1,685
    Mass (Da):187,627
    Last modified:November 4, 2008 - v2
    Checksum:iF0DBB25EB6323DF8
    GO
    Isoform 2 (identifier: P52179-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         836-931: Missing.

    Show »
    Length:1,589
    Mass (Da):177,700
    Checksum:iAB161B6C31ED4FDC
    GO

    Sequence cautioni

    The sequence CAA48833.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti247 – 2471E → G in CAA48833. (PubMed:7505783)Curated
    Sequence conflicti442 – 4421Q → R in CAA48833. (PubMed:7505783)Curated
    Sequence conflicti599 – 5991S → F in AAI16184. (PubMed:15489334)Curated
    Sequence conflicti601 – 6011P → A in CAA48833. (PubMed:7505783)Curated
    Sequence conflicti615 – 6151S → G in AAI16184. (PubMed:15489334)Curated
    Sequence conflicti616 – 62510RPSAPWTGQI → PLSTLDWTV in CAA48833. (PubMed:7505783)Curated
    Sequence conflicti776 – 7761S → N in CAA48833. (PubMed:7505783)Curated
    Sequence conflicti793 – 7942GS → TH in CAA48833. (PubMed:7505783)Curated
    Sequence conflicti992 – 9921S → R in CAA48833. (PubMed:7505783)Curated
    Sequence conflicti1001 – 10011L → S in BAC86128. (PubMed:14702039)Curated
    Sequence conflicti1080 – 10801Missing in CAA48833. (PubMed:7505783)Curated
    Sequence conflicti1141 – 11411T → R in CAA48833. (PubMed:7505783)Curated
    Sequence conflicti1615 – 16162SD → QT in CAA48833. (PubMed:7505783)Curated
    Sequence conflicti1617 – 16171D → G in BAC86128. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti22 – 221V → L.
    Corresponds to variant rs1791085 [ dbSNP | Ensembl ].
    VAR_047221
    Natural varianti181 – 1811S → P.3 Publications
    Corresponds to variant rs1962519 [ dbSNP | Ensembl ].
    VAR_047222
    Natural varianti215 – 2151T → M.
    Corresponds to variant rs2230165 [ dbSNP | Ensembl ].
    VAR_047223
    Natural varianti341 – 3411G → A.4 Publications
    Corresponds to variant rs8099021 [ dbSNP | Ensembl ].
    VAR_047224
    Natural varianti600 – 6001E → V.
    Corresponds to variant rs9807556 [ dbSNP | Ensembl ].
    VAR_047225
    Natural varianti960 – 9601I → T.3 Publications
    Corresponds to variant rs1071600 [ dbSNP | Ensembl ].
    VAR_047226
    Natural varianti1408 – 14081D → N.
    Corresponds to variant rs3765623 [ dbSNP | Ensembl ].
    VAR_047227
    Natural varianti1453 – 14531M → T.
    Corresponds to variant rs16944397 [ dbSNP | Ensembl ].
    VAR_047228

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei836 – 93196Missing in isoform 2. 2 PublicationsVSP_035663Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ621424 mRNA. Translation: CAF18565.1.
    AK125322 mRNA. Translation: BAC86128.1.
    AP005329 Genomic DNA. No translation available.
    AP005431 Genomic DNA. No translation available.
    BC116183 mRNA. Translation: AAI16184.1.
    X69090 mRNA. Translation: CAA48833.1. Different initiation.
    CCDSiCCDS45823.1. [P52179-2]
    CCDS45824.1. [P52179-1]
    PIRiS42167.
    RefSeqiNP_003794.3. NM_003803.3. [P52179-1]
    NP_062830.1. NM_019856.1. [P52179-2]
    UniGeneiHs.464469.

    Genome annotation databases

    EnsembliENST00000261606; ENSP00000261606; ENSG00000101605. [P52179-2]
    ENST00000356443; ENSP00000348821; ENSG00000101605. [P52179-1]
    GeneIDi8736.
    KEGGihsa:8736.
    UCSCiuc002klp.3. human. [P52179-1]
    uc002klq.3. human. [P52179-2]

    Polymorphism databases

    DMDMi212276443.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ621424 mRNA. Translation: CAF18565.1 .
    AK125322 mRNA. Translation: BAC86128.1 .
    AP005329 Genomic DNA. No translation available.
    AP005431 Genomic DNA. No translation available.
    BC116183 mRNA. Translation: AAI16184.1 .
    X69090 mRNA. Translation: CAA48833.1 . Different initiation.
    CCDSi CCDS45823.1. [P52179-2 ]
    CCDS45824.1. [P52179-1 ]
    PIRi S42167.
    RefSeqi NP_003794.3. NM_003803.3. [P52179-1 ]
    NP_062830.1. NM_019856.1. [P52179-2 ]
    UniGenei Hs.464469.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2R15 X-ray 2.24 A/B 1459-1667 [» ]
    2Y23 X-ray 2.50 A 1141-1447 [» ]
    2Y25 X-ray 3.50 A/B/C/D 1357-1667 [» ]
    3RBS X-ray 1.85 A 1247-1447 [» ]
    DisProti DP00517.
    ProteinModelPortali P52179.
    SMRi P52179. Positions 273-734, 751-834, 930-1024, 1039-1139, 1141-1666.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-59649N.
    IntActi P52179. 6 interactions.
    STRINGi 9606.ENSP00000348821.

    PTM databases

    PhosphoSitei P52179.

    Polymorphism databases

    DMDMi 212276443.

    Proteomic databases

    PaxDbi P52179.
    PRIDEi P52179.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000261606 ; ENSP00000261606 ; ENSG00000101605 . [P52179-2 ]
    ENST00000356443 ; ENSP00000348821 ; ENSG00000101605 . [P52179-1 ]
    GeneIDi 8736.
    KEGGi hsa:8736.
    UCSCi uc002klp.3. human. [P52179-1 ]
    uc002klq.3. human. [P52179-2 ]

    Organism-specific databases

    CTDi 8736.
    GeneCardsi GC18M003056.
    H-InvDB HIX0017329.
    HGNCi HGNC:7613. MYOM1.
    HPAi HPA014305.
    MIMi 603508. gene.
    neXtProti NX_P52179.
    PharmGKBi PA31418.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG281933.
    HOGENOMi HOG000293283.
    HOVERGENi HBG004977.
    InParanoidi P52179.
    OMAi YIIESRY.
    OrthoDBi EOG7MSMN2.
    PhylomeDBi P52179.
    TreeFami TF331825.

    Miscellaneous databases

    EvolutionaryTracei P52179.
    GeneWikii MYOM1.
    GenomeRNAii 8736.
    NextBioi 32769.
    PROi P52179.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P52179.
    Bgeei P52179.
    CleanExi HS_MYOM1.
    Genevestigatori P52179.

    Family and domain databases

    Gene3Di 2.60.40.10. 12 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    [Graphical view ]
    Pfami PF00041. fn3. 5 hits.
    PF07679. I-set. 5 hits.
    [Graphical view ]
    SMARTi SM00060. FN3. 5 hits.
    SM00409. IG. 3 hits.
    SM00408. IGc2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 3 hits.
    PROSITEi PS50853. FN3. 5 hits.
    PS50835. IG_LIKE. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "SUMO modification of the M-band protein myomesin."
      Hayess K., Matschke K., Fuerst D.O.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ALA-341 AND THR-960.
      Tissue: Skeletal muscle.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS PRO-181; ALA-341 AND THR-960.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS PRO-181 AND ALA-341.
    5. "The globular head domain of titin extends into the center of the sarcomeric M band. cDNA cloning, epitope mapping and immunoelectron microscopy of two titin-associated proteins."
      Vinkemeier U., Obermann W., Weber K., Fuerst D.O.
      J. Cell Sci. 106:319-330(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 99-1685 (ISOFORM 2), VARIANTS PRO-181; ALA-341 AND THR-960.
      Tissue: Skeletal muscle.
    6. "Characterization of MR-1, a novel myofibrillogenesis regulator in human muscle."
      Li T.-B., Liu X.-H., Feng S., Hu Y., Yang W.-X., Han Y., Wang Y.-G., Gong L.-M.
      Acta Biochim. Biophys. Sin. 36:412-418(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PNKD.

    Entry informationi

    Entry nameiMYOM1_HUMAN
    AccessioniPrimary (citable) accession number: P52179
    Secondary accession number(s): Q14BD6, Q6H969, Q6ZUU0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: November 4, 2008
    Last modified: October 1, 2014
    This is version 123 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3