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Protein

Interleukin-5

Gene

IL5

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor

Enzyme and pathway databases

ReactomeiR-BTA-392451 G beta:gamma signalling through PI3Kgamma
R-BTA-512988 Interleukin-3, 5 and GM-CSF signaling
R-BTA-5673001 RAF/MAP kinase cascade
R-BTA-912526 Interleukin receptor SHC signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-5
Short name:
IL-5
Alternative name(s):
Eosinophil differentiation factor
T-cell replacing factor
Short name:
TRF
Gene namesi
Name:IL5
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Organism-specific databases

VGNCiVGNC:30164 IL5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000001555422 – 134Interleukin-5Add BLAST113

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi63Interchain (with C-105)By similarity
Glycosylationi76N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi90N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi105Interchain (with C-63)By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP52173

Expressioni

Gene expression databases

BgeeiENSBTAG00000031235

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000041739

Structurei

3D structure databases

ProteinModelPortaliP52173
SMRiP52173
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-5 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYJN Eukaryota
ENOG41117ER LUCA
GeneTreeiENSGT00390000016991
HOGENOMiHOG000074049
HOVERGENiHBG003865
InParanoidiP52173
KOiK05428
OMAiGVINTEW
OrthoDBiEOG091G0XPD
TreeFamiTF338422

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000186 IL-5
PANTHERiPTHR45421 PTHR45421, 1 hit
PfamiView protein in Pfam
PF02025 IL5, 1 hit
PRINTSiPR00432 INTERLEUKIN5
ProDomiView protein in ProDom or Entries sharing at least one domain
PD006721 Interleukin_5, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52173-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRMHLHLTLV ALGAAYVCAN AVESTMNRLV AETLTLLSSH RTLLIGDGNL
60 70 80 90 100
MIPTPQHTNH QLCIEEVFQG IDTLKNQTAQ GDAVKKIFQN LSLIKEYIDL
110 120 130
QKRKCGGERW RVKQFLDYLQ VFLGVINTEW TMES
Length:134
Mass (Da):15,229
Last modified:October 1, 1996 - v1
Checksum:i0B3A2328EE7431F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z67872 mRNA Translation: CAA91779.1
EU276070 mRNA Translation: ABX72068.1
PIRiJC5116
RefSeqiNP_776347.1, NM_173922.1
UniGeneiBt.5

Genome annotation databases

EnsembliENSBTAT00000044228; ENSBTAP00000041739; ENSBTAG00000031235
GeneIDi280825
KEGGibta:280825

Similar proteinsi

Entry informationi

Entry nameiIL5_BOVIN
AccessioniPrimary (citable) accession number: P52173
Secondary accession number(s): A9QWQ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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