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Protein

Interleukin-5

Gene

IL5

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Enzyme and pathway databases

ReactomeiR-BTA-114604. GPVI-mediated activation cascade.
R-BTA-392451. G beta:gamma signalling through PI3Kgamma.
R-BTA-512988. Interleukin-3, 5 and GM-CSF signaling.
R-BTA-5673001. RAF/MAP kinase cascade.
R-BTA-912526. Interleukin receptor SHC signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-5
Short name:
IL-5
Alternative name(s):
Eosinophil differentiation factor
T-cell replacing factor
Short name:
TRF
Gene namesi
Name:IL5
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121By similarityAdd
BLAST
Chaini22 – 134113Interleukin-5PRO_0000015554Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi63 – 63Interchain (with C-105)By similarity
Glycosylationi76 – 761N-linked (GlcNAc...)Sequence analysis
Glycosylationi90 – 901N-linked (GlcNAc...)Sequence analysis
Disulfide bondi105 – 105Interchain (with C-63)By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP52173.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000041739.

Structurei

3D structure databases

ProteinModelPortaliP52173.
SMRiP52173. Positions 29-130.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-5 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYJN. Eukaryota.
ENOG41117ER. LUCA.
GeneTreeiENSGT00390000016991.
HOGENOMiHOG000074049.
HOVERGENiHBG003865.
InParanoidiP52173.
KOiK05428.
OMAiGVINTEW.
OrthoDBiEOG70PC0S.
TreeFamiTF338422.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000186. IL-5.
[Graphical view]
PANTHERiPTHR10525. PTHR10525. 1 hit.
PfamiPF02025. IL5. 1 hit.
[Graphical view]
PRINTSiPR00432. INTERLEUKIN5.
ProDomiPD006721. Interleukin_5. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52173-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRMHLHLTLV ALGAAYVCAN AVESTMNRLV AETLTLLSSH RTLLIGDGNL
60 70 80 90 100
MIPTPQHTNH QLCIEEVFQG IDTLKNQTAQ GDAVKKIFQN LSLIKEYIDL
110 120 130
QKRKCGGERW RVKQFLDYLQ VFLGVINTEW TMES
Length:134
Mass (Da):15,229
Last modified:October 1, 1996 - v1
Checksum:i0B3A2328EE7431F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z67872 mRNA. Translation: CAA91779.1.
EU276070 mRNA. Translation: ABX72068.1.
PIRiJC5116.
RefSeqiNP_776347.1. NM_173922.1.
UniGeneiBt.5.

Genome annotation databases

EnsembliENSBTAT00000044228; ENSBTAP00000041739; ENSBTAG00000031235.
GeneIDi280825.
KEGGibta:280825.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z67872 mRNA. Translation: CAA91779.1.
EU276070 mRNA. Translation: ABX72068.1.
PIRiJC5116.
RefSeqiNP_776347.1. NM_173922.1.
UniGeneiBt.5.

3D structure databases

ProteinModelPortaliP52173.
SMRiP52173. Positions 29-130.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000041739.

Proteomic databases

PaxDbiP52173.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000044228; ENSBTAP00000041739; ENSBTAG00000031235.
GeneIDi280825.
KEGGibta:280825.

Organism-specific databases

CTDi3567.

Phylogenomic databases

eggNOGiENOG410IYJN. Eukaryota.
ENOG41117ER. LUCA.
GeneTreeiENSGT00390000016991.
HOGENOMiHOG000074049.
HOVERGENiHBG003865.
InParanoidiP52173.
KOiK05428.
OMAiGVINTEW.
OrthoDBiEOG70PC0S.
TreeFamiTF338422.

Enzyme and pathway databases

ReactomeiR-BTA-114604. GPVI-mediated activation cascade.
R-BTA-392451. G beta:gamma signalling through PI3Kgamma.
R-BTA-512988. Interleukin-3, 5 and GM-CSF signaling.
R-BTA-5673001. RAF/MAP kinase cascade.
R-BTA-912526. Interleukin receptor SHC signaling.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000186. IL-5.
[Graphical view]
PANTHERiPTHR10525. PTHR10525. 1 hit.
PfamiPF02025. IL5. 1 hit.
[Graphical view]
PRINTSiPR00432. INTERLEUKIN5.
ProDomiPD006721. Interleukin_5. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47266. SSF47266. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of the bovine interleukin-5-encoding cDNA."
    Mertens B., Gobright E., Seow H.F.
    Gene 176:273-274(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Blood.
  2. "U.S. veterinary immune reagent network: expressed bovine gene sequences."
    U.S. Veterinary Immune Reagent Network
    Hudgens T., Tompkins D., Baldwin C.L.
    Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Belted Galloway.
    Tissue: Peripheral blood.

Entry informationi

Entry nameiIL5_BOVIN
AccessioniPrimary (citable) accession number: P52173
Secondary accession number(s): A9QWQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 8, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.