P52147 (ARSC2_ECOLX) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arsenate reductase
EC=1.20.4.1

Alternative name(s):
Arsenical pump modifier

Gene names

Name:

arsC

Encoded on

Plasmid IncN R46

Organism

Escherichia coli

Taxonomic identifier

562 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	141 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Reduction of arsenate [As(V)] to arsenite [As(III)]. This protein expands the substrate specificity of ArsAB pump which can extrude arsenite and antimonite to allow for arsenate pumping and resistance.
Catalytic activity	Arsenate + glutaredoxin = arsenite + glutaredoxin disulfide + H2O.
Sequence similarities	Belongs to the ArsC family.

Ontologies

Keywords
Biological process	Arsenical resistance
Molecular function	Oxidoreductase
Technical term	Plasmid
Gene Ontology (GO)
Biological process	response to arsenic-containing substance Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	arsenate reductase (glutaredoxin) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 141	141	Arsenate reductase		PRO_0000162538

Sequences

	Sequence		Length	Mass (Da)
	P52147 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 31325DBFA7C9D005	FASTA	141	15,853
	10 20 30 40 50 60 MSNITIYHNP HCGTSRNTLE MIRNSGIEPT VILYLETPPS RDELLKLIAD MGISVRALLR 70 80 90 100 110 120 KNVEPYEELG LAEDKFTDDQ LIDFMLQHPI LINRPIVVTP LGTKLCRPSE VVLDILPDAQ 130 140 KAAFTKEDGE KVVDDSGKRL K

References

[1]	"The arsenical resistance operon of IncN plasmid R46." Bruhn D.F., Li J., Silver S., Roberto F., Rosen B.P. FEMS Microbiol. Lett. 139:149-153(1996) [PubMed: 8674982] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U38947 Genomic DNA. Translation: AAB09628.1.
3D structure databases
ProteinModelPortal	P52147.
SMR	P52147. Positions 3-140.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR006659. Arsenate_reductase. IPR006660. Arsenate_reductase-like. IPR012336. Thioredoxin-like_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF03960. ArsC. 1 hit. [Graphical view]
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
TIGRFAMs	TIGR00014. ArsC. 1 hit.
PROSITE	PS51353. ARSC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARSC2_ECOLX

Accession

Primary (citable) accession number: P52147

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	July 27, 2011
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program