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Protein

Putative antitoxin YfjZ

Gene

yfjZ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Might be an antitoxin component of a toxin-antitoxin (TA) module. A putative antitoxin that may inactivate probable toxin YpjF (Potential).Curated

Enzyme and pathway databases

BioCyciEcoCyc:G7380-MONOMER.
ECOL316407:JW2626-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative antitoxin YfjZ
Gene namesi
Name:yfjZ
Ordered Locus Names:b2645, JW2626
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13212. yfjZ.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 105105Putative antitoxin YfjZPRO_0000169285Add
BLAST

Proteomic databases

PaxDbiP52141.
PRIDEiP52141.

Interactioni

Protein-protein interaction databases

BioGridi4262252. 14 interactions.
IntActiP52141. 1 interaction.
STRINGi511145.b2645.

Structurei

Secondary structure

1
105
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 84Combined sources
Beta strandi12 – 2312Combined sources
Beta strandi26 – 283Combined sources
Helixi31 – 333Combined sources
Beta strandi34 – 385Combined sources
Helixi44 – 6522Combined sources
Beta strandi66 – 683Combined sources
Beta strandi75 – 806Combined sources
Beta strandi83 – 886Combined sources
Beta strandi93 – 10210Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EA9X-ray2.10A1-105[»]
2JN7NMR-A1-105[»]
ProteinModelPortaliP52141.
SMRiP52141. Positions 1-103.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP52141.

Family & Domainsi

Sequence similaritiesi

Belongs to the CbeA/YafW/YfjZ antitoxin family.Curated

Phylogenomic databases

eggNOGiENOG4105MAW. Bacteria.
ENOG4111V4B. LUCA.
HOGENOMiHOG000290944.
KOiK18838.
OMAiHDGFTCE.
OrthoDBiEOG66HVJ7.
PhylomeDBiP52141.

Family and domain databases

InterProiIPR009320. YagB_YeeU_YfjZ.
[Graphical view]
PfamiPF06154. CbeA_antitoxin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52141-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNTTWGLQR DITPRLGARL VQEGNQLHYL ADRASITGKF SDAECPKLDV
60 70 80 90 100
VFPHFISQIE SMLTTGELNP RHAQCVTLYH NGFTCEADTL GSCGYVYIAV

YPTQR
Length:105
Mass (Da):11,737
Last modified:October 1, 1996 - v1
Checksum:i3E3838D48C7A527D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36840 Genomic DNA. Translation: AAA79813.1.
U00096 Genomic DNA. Translation: AAC75693.1.
AP009048 Genomic DNA. Translation: BAA16513.1.
PIRiT08656.
RefSeqiNP_417132.1. NC_000913.3.
WP_000072690.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75693; AAC75693; b2645.
BAA16513; BAA16513; BAA16513.
GeneIDi947123.
KEGGiecj:JW2626.
eco:b2645.
PATRICi32120685. VBIEscCol129921_2741.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36840 Genomic DNA. Translation: AAA79813.1.
U00096 Genomic DNA. Translation: AAC75693.1.
AP009048 Genomic DNA. Translation: BAA16513.1.
PIRiT08656.
RefSeqiNP_417132.1. NC_000913.3.
WP_000072690.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EA9X-ray2.10A1-105[»]
2JN7NMR-A1-105[»]
ProteinModelPortaliP52141.
SMRiP52141. Positions 1-103.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262252. 14 interactions.
IntActiP52141. 1 interaction.
STRINGi511145.b2645.

Proteomic databases

PaxDbiP52141.
PRIDEiP52141.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75693; AAC75693; b2645.
BAA16513; BAA16513; BAA16513.
GeneIDi947123.
KEGGiecj:JW2626.
eco:b2645.
PATRICi32120685. VBIEscCol129921_2741.

Organism-specific databases

EchoBASEiEB3004.
EcoGeneiEG13212. yfjZ.

Phylogenomic databases

eggNOGiENOG4105MAW. Bacteria.
ENOG4111V4B. LUCA.
HOGENOMiHOG000290944.
KOiK18838.
OMAiHDGFTCE.
OrthoDBiEOG66HVJ7.
PhylomeDBiP52141.

Enzyme and pathway databases

BioCyciEcoCyc:G7380-MONOMER.
ECOL316407:JW2626-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP52141.
PROiP52141.

Family and domain databases

InterProiIPR009320. YagB_YeeU_YfjZ.
[Graphical view]
PfamiPF06154. CbeA_antitoxin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features."
    Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T.
    , Oyama S., Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H., Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.
    DNA Res. 4:91-113(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Crystal structure of a hypothetical protein JW2626 from E. coli."
    RIKEN structural genomics initiative (RSGI)
    Submitted (JUL-2007) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).
  5. "NMR solution structure of E.coli hypothetical protein YfjZ."
    Northeast structural genomics consortium (NESG)
    Submitted (FEB-2009) to the PDB data bank
    Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiYFJZ_ECOLI
AccessioniPrimary (citable) accession number: P52141
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: January 20, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.