Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Antitoxin RnlB

Gene

rnlB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Antitoxin component of a type II toxin-antitoxin (TA) system. A labile antitoxin (half-life of 2.1 minutes) that inhibits the endonuclease activity of cognate toxin RnlA but not that of non-cognate toxin LsoA.2 Publications

GO - Biological processi

  • negative regulation of endoribonuclease activity Source: EcoCyc

Keywordsi

Biological processToxin-antitoxin system

Enzyme and pathway databases

BioCyciEcoCyc:G7366-MONOMER
MetaCyc:G7366-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Antitoxin RnlB
Gene namesi
Name:rnlB
Synonyms:yfjO
Ordered Locus Names:b2631, JW5418
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13201 rnlB

Pathology & Biotechi

Disruption phenotypei

Essential, it cannot be deleted unless rnlA is also disrupted.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001692801 – 123Antitoxin RnlBAdd BLAST123

Post-translational modificationi

Probably degraded by CplXP and Lon proteases.

Proteomic databases

PaxDbiP52130
PRIDEiP52130

Expressioni

Inductioni

Not repressed by IscR. rnlA-rnlB forms an operon, the downstream rnlB also has its own promoter.1 Publication

Interactioni

Subunit structurei

Can form a complex with cognate toxin RnlA.

Protein-protein interaction databases

BioGridi4261565, 15 interactors
STRINGi316385.ECDH10B_2797

Structurei

3D structure databases

ProteinModelPortaliP52130
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4106BHJ Bacteria
ENOG410Y1RN LUCA
OMAiCSNGFEW

Family and domain databases

InterProiView protein in InterPro
IPR031834 RnlB/LsoB_antitoxin
PfamiView protein in Pfam
PF15933 RnlB_antitoxin, 1 hit

Sequencei

Sequence statusi: Complete.

P52130-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFEITGINVS GALKAVVMAT GFENPLSSVN EIETKLSALL GSETTGEILF
60 70 80 90 100
DLLCANGPEW NRFVTLEMKY GRIMLDTAKI IDEQDVPTHI LSKLTFTLRN
110 120
HPEYLEASVL SPDDVRQVLS MDF
Length:123
Mass (Da):13,665
Last modified:December 1, 2000 - v2
Checksum:i721D9EDE233E8D12
GO

Sequence cautioni

The sequence AAA79800 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36840 Genomic DNA Translation: AAA79800.1 Different initiation.
U00096 Genomic DNA Translation: AAC75679.2
AP009048 Genomic DNA Translation: BAE76766.1
PIRiT08643
RefSeqiNP_417120.2, NC_000913.3
WP_000461704.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75679; AAC75679; b2631
BAE76766; BAE76766; BAE76766
GeneIDi947113
KEGGiecj:JW5418
eco:b2631
PATRICifig|511145.12.peg.2725

Similar proteinsi

Entry informationi

Entry nameiRNLB_ECOLI
AccessioniPrimary (citable) accession number: P52130
Secondary accession number(s): Q2MAE0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 1, 2000
Last modified: March 28, 2018
This is version 95 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health